Social and Behavioral Sciences Commons^™

Single Molecule Characterization Of The Interactions Between Amyloid-Β Peptides And The Membranes Of Hippocampal Cells, Priyanka Narayan, Kristina A. Ganzinger, James Mccoll, Laura Weimann, Sarah Meehan, Seema Qamar, John A. Carver, Mark R. Wilson, Peter St George-Hyslop, Christopher M. Dobson, David Klenerman

Faculty of Science, Medicine and Health - Papers: part A

Oligomers of the 40 and 42 residue amyloid-β peptides (Aβ40 and Aβ42) have been implicated in the neuronal damage and impaired cognitive function associated with Alzheimer’s disease. However, little is known about the specific mechanisms by which these misfolded species induce such detrimental effects on cells. In this work, we use single-molecule imaging techniques to examine the initial interactions between Aβ monomers and oligomers and the membranes of live cells. This highly sensitive method enables the visualization of individual Aβ species on the cell surface and characterization of their oligomerization state, all at biologically relevant, nanomolar concentrations. The results indicate …

Coastal Evolution On Volcanic Oceanic Islands: A Complex Interplay Between Volcanism, Erosion, Sedimentation, Sea-Level Change And Biogenic Production, Ricardo S. Ramalho, Rui Quartau, Alan S. Trenhaile, Neil C. Mitchell, Colin D. Woodroffe, Sergio P. Avila

Faculty of Science, Medicine and Health - Papers: part A

The growth and decay of oceanic hotspot volcanoes are intrinsically related to a competition between volcanic construction and erosive destruction, and coastlines are at the forefront of such confrontation. In this paper, we review the several mechanisms that interact and contribute to the development of coastlines on oceanic island volcanoes, and how these processes evolve throughout the islands' lifetime. Volcanic constructional processes dominate during the emergent island and subaerial shield-building stages. During the emergent island stage, surtseyan activity prevails and hydroclastic and pyroclastic structures form; these structures are generally ephemeral because they can be rapidly obliterated by marine erosion. With …

Facilitating Better Health Care For Mental Health Consumers Through Engagement: Complexities Of Establishing A Partnership Pilot Program Between Mental Health Professionals And University Exercise Physiology Students, Angela Douglas, Alex Gagan, Keirin Mccormack, Sarah Lisle

Faculty of Science, Medicine and Health - Papers: part A

Abstract of the oral presentation.

Abrupt Transitions Between Macrobenthic Faunal Assemblages Across Seagrass Bed Margins, R.S.K Barnes, S Hamylton

Faculty of Science, Medicine and Health - Papers: part A

The nature of the transition from one contrasting macrobenthic assemblage to another across interfaces between intertidal seagrass and unvegetated sand was investigated in the subtropical Moreton Bay Marine Park, eastern Australia, via six two-dimensional core lattices. The same pattern of transition was manifested in each lattice. Macrofaunal abundance, species density (both observed and estimated total) and assemblage composition did not vary with distance away from the interface within the 0.75 m wide marginal bands of each habitat type. Neither were there significant differences in assemblage metrics or composition between the marginal and non-edge regions of either habitat. There were, however, …

A Geospatial Assessment Of The Relationship Between Reef Flat Community Calcium Carbonate Production And Wave Energy, S M. Hamylton, A Pescud, J X. Leon, D Callaghan

Faculty of Science, Medicine and Health - Papers: part A

The ability of benthic communities inhabiting coral reefs to produce calcium carbonate underpins the development of reef platforms and associated sedimentary landforms, as well as the fixation of inorganic carbon and buffering of diurnal pH fluctuations in ocean surface waters. Quantification of the relationship between reef flat community calcium carbonate production and wave energy provides an empirical basis for understanding and managing this functionally important process. This study employs geospatial techniques across the reef platform at Lizard Island, Great Barrier Reef, to (1) map the distribution and estimate the total magnitude of reef community carbonate production and (2) empirically ascertain …

Variation In Personality Traits Of Medical Students Between Schools Of Medicine, Ian Wilson, Barbara Griffin, Lisa Lampe, Diann Eley, Gerry Corrigan, Brian Kelly, Pamela Stagg

Faculty of Science, Medicine and Health - Papers: part A

Introduction: While there have been studies exploring the impact of personality on medical student selection and performance there has not been an investigation of the personality of students at different schools.

Method: Demographic data and responses to the NEO measure of personality traits were collected from medical students in the first two weeks of their enrolment (2011) in seven medical schools in Australia. Personality traits were analysed by school features, gender and age using logistic regression.

Results: Differences were detected between schools in the personality traits of Agreeableness and Conscientiousness. Higher Agreeableness and Conscientiousness were associated with attending an Undergraduate …

Proofreading Exonuclease On A Tether: The Complex Between The E. Coli Dna Polymerase Iii Subunits Α, Ε, Θ And Β Reveals A Highly Flexible Arrangement Of The Proofreading Domain, Kiyoshi Ozawa, Nicholas P. Horan, Andrew Robinson, Hiromasa Yagi, Flynn R. Hill, Slobodan Jergic, Zhi-Qiang Xu, Karin V. Loscha, Nan Li, Moeava Tehei, Aaron J. Oakley, Gottfried Otting, Thomas Huber, Nicholas E. Dixon

Faculty of Science, Medicine and Health - Papers: part A

A complex of the three (αεθ) core subunits and the β2 sliding clamp is responsible for DNA synthesis by Pol III, the Escherichia coli chromosomal DNA replicase. The 1.7 Å crystal structure of a complex between the PHP domain of α (polymerase) and the C-terminal segment of ε (proofreading exonuclease) subunits shows that ε is attached to α at a site far from the polymerase active site. Both α and ε contain clamp-binding motifs (CBMs) that interact simultaneously with β2 in the polymerization mode of DNA replication by Pol III. Strengthening of both CBMs enables isolation of stable αεθ:β2 complexes. …

Real-Time Single-Molecule Imaging Reveals A Direct Interaction Between Uvrc And Uvrb On Dna Tightropes, Craig D. Hughes, Hong Wang, Harshad Ghodke, Michelle Simons, Atif Towheed, Ye Peng, Bennett Van Houten, Neil M. Kad

Faculty of Science, Medicine and Health - Papers: part A

Nucleotide excision DNA repair is mechanistically conserved across all kingdoms of life. In prokaryotes, this multi-enzyme process requires six proteins: UvrA-D, DNA polymerase I and DNA ligase. To examine how UvrC locates the UvrB-DNA pre-incision complex at a site of damage, we have labeled UvrB and UvrC with different colored quantum dots and quantitatively observed their interactions with DNA tightropes under a variety of solution conditions using oblique angle fluorescence imaging. Alone, UvrC predominantly interacts statically with DNA at low salt. Surprisingly, however, UvrC and UvrB together in solution bind to form the previously unseen UvrBC complex on duplex DNA. …

Falling Between The 'Service Cracks': Women Living With Alcohol-Related Brain Injury (Arbi), Renee Brighton, Lorna Moxham, Victoria Traynor

Faculty of Science, Medicine and Health - Papers: part A

Abstract of paper that presented at the 1st Australasian Mental Health and Addiction Nursing Conference.

Clinical Placements In General Practice: Relationships Between Practice Nurses And Tertiary Institutions, Kath Peters, Elizabeth J. Halcomb, Susan Mcinnes

Faculty of Science, Medicine and Health - Papers: part A

As a practice-based discipline a key component of undergraduate nurse education is clinical practice experience. The quality of clinical experiences has a significant impact on the students' ability to function competently post graduation. The relationship between higher education institutions (HEIs) and health service placement providers impacts upon the quality of clinical placements. In Australia, the growth of primary care nursing and the shortage of acute clinical places has prompted HEIs to explore the placement of students in general practice. Given the increasing attention being paid to non-traditional clinical placements, it is timely to explore how universities are establishing relationships and …