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Articles 1 - 6 of 6
Full-Text Articles in Social and Behavioral Sciences
Streptococcus Pyogenes Prtfii, But Not Sfbi, Sfbii Or Fbp54, Is Represented More Frequently Among Invasive-Disease Isolates Of Tropical Australia, A. Delvecchio, B. J. Currie, Jason D. Mcarthur, Mark J. Walker, K. S. Sriprakash
Streptococcus Pyogenes Prtfii, But Not Sfbi, Sfbii Or Fbp54, Is Represented More Frequently Among Invasive-Disease Isolates Of Tropical Australia, A. Delvecchio, B. J. Currie, Jason D. Mcarthur, Mark J. Walker, K. S. Sriprakash
Faculty of Science - Papers (Archive)
Streptococcus pyogenes (group A streptococcus) strains may express several distinct ®bronectinbinding proteins (FBPs) which are considered as major streptococcal adhesins. Of the FBPs, SfbI was shown in Šitro to promote internalization of the bacterium into host cells and has been implicated in persistence. In the tropical Northern Territory, where group A streptococcal infection is common, multiple genotypes of the organism were found among isolates from invasive disease cases and no dominant strains were observed. To determine whether any FBPs is associated with invasive disease propensity of S. pyogenes, we have screened streptococcal isolates from bacteraemic and necrotizing fasciitis patients and …
Considerations For Capping Metal-Contaminated Sediments In Dynamic Estuarine Environments, Stuart L. Simpson, Ian D. Pryor, Ben R. Mewburn, Graeme E. Batley, Dianne F. Jolley
Considerations For Capping Metal-Contaminated Sediments In Dynamic Estuarine Environments, Stuart L. Simpson, Ian D. Pryor, Ben R. Mewburn, Graeme E. Batley, Dianne F. Jolley
Faculty of Science - Papers (Archive)
The effects of tides, bioturbating organisms and periods of anoxia on metal fluxes from contaminated harbour sediments in a shallow tidal estuarine bay were studied, together with capping technology options for the containment of metal contaminants. Zinc fluxes from the sediments were high, ranging from 10 to 89 mg Zn /m2/day. In the absence of capping, experiments in corer reactors showed that simulated tidal processes increased zinc fluxes 5- fold. Fluxes were also greater in the presence of sediment-dwelling organisms. If organisms were removed, and recolonising organisms later added, their bioturbation activities initially lowered zinc fluxes, but fluxes …
Clusterin Is An Extracellular Chaperone That Specifically Interacts With Slowly Aggregating Proteins On Their Off-Folding Pathway, Stephen Poon, T. M. Treweek, Mark R. Wilson, Simon B. Easterbrook-Smith, John A. Carver
Clusterin Is An Extracellular Chaperone That Specifically Interacts With Slowly Aggregating Proteins On Their Off-Folding Pathway, Stephen Poon, T. M. Treweek, Mark R. Wilson, Simon B. Easterbrook-Smith, John A. Carver
Faculty of Science - Papers (Archive)
Clusterin is an extracellular mammalian chaperone protein which inhibits stress-induced precipitation of many different proteins. The conformational state(s) of proteins that interact with clusterin and the stage(s) along the folding and off-folding (precipitation-bound) pathways where this interaction occurs were previously unknown. We investigated this by examining the interactions of clusterin with different structural forms of α-lactalbumin, γ-crystallin and lysozyme. When assessed by ELISA and native gel electrophoresis, clusterin did not bind to various stable, intermediately folded states of α-lactalbumin nor to the native form of this protein, but did bind to and inhibit the slow precipitation of reduced α-lactalbumin. Reduction-induced …
Mildly Acidic Ph Activates The Extracellular Molecular Chaperone Clusterin, Stephen Poon, M. S. Rybchyn, S. B. Easterbrook-Smith, J. A. Carver, G. J. Pankhurst, Mark R. Wilson
Mildly Acidic Ph Activates The Extracellular Molecular Chaperone Clusterin, Stephen Poon, M. S. Rybchyn, S. B. Easterbrook-Smith, J. A. Carver, G. J. Pankhurst, Mark R. Wilson
Faculty of Science - Papers (Archive)
Many features of the chaperone action of clusterin are similar to those of the intracellular small heat shock proteins (sHSPs) which, like clusterin, exist in solution as heterogeneous aggregates. Increased temperature induces dissociation of some sHSP aggregates and an enhanced chaperone action, suggesting that a dissociated form is the active chaperone species. We recently reported that clusterin aggregates dissociate at mildly acidic pH. To further explore the similarities between clusterin and the sHSPs, we tested the effects of temperature and pH on the structure of clusterin and its chaperone action. Our results demonstrate that increased temperature does not induce dissociation …
Synthesis Of (+/-)Epipentenomycin I And Iii, Weerachai Phutdhawong, Stephen G. Pyne, Apiwat Baramee, Duang Buddhasukh, Brian W. Skelton, Allan H. White
Synthesis Of (+/-)Epipentenomycin I And Iii, Weerachai Phutdhawong, Stephen G. Pyne, Apiwat Baramee, Duang Buddhasukh, Brian W. Skelton, Allan H. White
Faculty of Science - Papers (Archive)
A synthesis of (±) epipentenomycin I and III is reported from a regioselective epoxidation of racemic 3-hydroxy- and 3-acetoxy-2-methylene-4-cyclopentenone, respectively, with dimethyldioxirane followed by hydrolytic ring-opening of the resulting epoxide.
Synthesis Of Chiral Allylic Amines Via Palladium(0) Catalysed Allylations Of Allylic Carbonates With Chiral Sulfinamide Anions, Zemin Dong, Stephen G. Pyne
Synthesis Of Chiral Allylic Amines Via Palladium(0) Catalysed Allylations Of Allylic Carbonates With Chiral Sulfinamide Anions, Zemin Dong, Stephen G. Pyne
Faculty of Science - Papers (Archive)
The palladium(0) catalysed allylation reactions of allylic carbonates with chiral sulfinamide anions to give unstable allylic sulfinamide products are described. These products are readily converted to stable, chiral N-benzoyl or N-tosyl allylic amine derivatives with poor to modest enantiomeric purities (ee 23-41%).