Social and Behavioral Sciences Commons^™

Systematic Enso-Driven Nutrient Variability Recorded By Central Equatorial Pacific Corals, Michele Lavigne, Intan S. Nurhati, Kim M. Cobb, Helen V. Mcgregor, Daniel Sinclair, Robert M. Sherrell

Faculty of Science, Medicine and Health - Papers: part A

[1] Variations in ocean productivity are driven largely by nutrient supply to the photic zone, but temporal records of nutrient variability are sparse. Here we show scleractinian coral P/Ca proxy records of variations in phosphate concentrations during El Niño Southern Oscillation (ENSO) cycles in the central equatorial Pacific. Covarying P/Ca records in Porites corals from Christmas and Fanning Islands show a regional ~40% decrease during the upwelling relaxation of the 1997–1998 El Niño, consistent with less frequent nutrient measurements from this area. Similar ~35–45% skeletal P/Ca decreases occur during the 1982–1983 and 1986–1987 El Niño events, which predate satellite color …

Rapid Cascade Synthesis Of Poly-Heterocyclic Architectures From Indigo, Alireza Shakoori Ghasabi, John Bremner, Anthony C. Willis, Rachada Haritakun, Paul A. Keller

Faculty of Science, Medicine and Health - Papers: part A

The base-induced propargylation of the dye indigo results in the rapid and unprecedented one-pot synthesis of highly functionalized representatives of the pyrazino[1,2-a:4,3-a′]diindole, pyrido[1,2-a:3,4-b′]diindole and benzo[b]indolo[1,2-h]naphthyridine heterocyclic systems, with the last two reflecting the core skeleton of the anticancer/antiplasmodial marine natural products fascaplysin and homofascaplysins and a ring B-homologue, respectively. The polycyclic compounds 6–8, whose structures were confirmed through single-crystal X-ray crystallographic analysis, arise from sequential inter/intramolecular substitution–addition reactions, and in some cases, ring rearrangement reactions. Preliminary studies on controlling the reaction path selectivity, and the potential reaction mechanisms, are also described. Initial biological activity studies with these new heterocyclic derivatives …

Rates Of Shoreline Change Along The Coast Of Bangladesh, Md. Golam Mahabub Sarwar, Colin D. Woodroffe

Faculty of Science, Medicine and Health - Papers: part A

Bangladesh, at the confluence of the sediment-laden Ganges and Brahmaputra Rivers, supports an enormous and rapidly growing population (>140 million in 2011), across low-lying alluvial and delta plains that have accumulated over the past few thousand years. It has been identified as one of the most vulnerable places in the world to the impacts of climate change and sea-level rise. Although abundant sediment supply has resulted in accretion on some parts of the coast of Bangladesh, others are experiencing rapid erosion. We report a systematic assessment of rates of shoreline change over a 20-year period from 1989 to 2009, …

Concise Synthesis Of (-)-Steviamine And Analogues And Their Glycosidase Inhibitory Activities, Nadechanok Jiangseubchatveera, Marc E. Bouillon, Boonsom Liawruangrath, Saisunee Liawruangrath, Robert J. Nash, Stephen G. Pyne

Faculty of Science, Medicine and Health - Papers: part A

A concise synthesis of (−)-steviamine is reported along with the synthesis of its analogues 10-nor-steviamine, 10-nor-ent-steviamine and 5-epi-ent-steviamine. These compounds were tested against twelve glycosidases (at 143 μg mL−1 concentrations) and were found to have in general poor inhibitory activity against most enzymes. The 10-nor analogues however, showed 50–54% inhibition of α-L-rhamnosidase from Penicillium decumbens while one of these, 10-nor-steviamine, showed 51% inhibition of N-acetyl-β-D-glucosaminidase (from Jack bean) at the same concentration (760 μM).

Uv Photodissociation Action Spectroscopy Of Haloanilinium Ions In A Linear Quadrupole Ion Trap Mass Spectrometer, Christopher S. Hansen, Benjamin B. Kirk, Stephen J. Blanksby, Richard A. J O'Hair, Adam J. Trevitt

Faculty of Science, Medicine and Health - Papers: part A

UV-vis photodissociation action spectroscopy is becoming increasingly prevalent because of advances in, and commercial availability of, ion trapping technologies and tunable laser sources. This study outlines in detail an instrumental arrangement, combining a commercial ion-trap mass spectrometer and tunable nanosecond pulsed laser source, for performing fully automated photodissociation action spectroscopy on gas-phase ions. The components of the instrumentation are outlined, including the optical and electronic interfacing, in addition to the control software for automating the experiment and performing online analysis of the spectra. To demonstrate the utility of this ensemble, the photodissociation action spectra of 4-chloroanilinium, 4-bromoanilinium, and 4-iodoanilinium cations …

Switching Radical Stability By Ph-Induced Orbital Conversion, Ganna Gryn'ova, David L. Marshall, Stephen J. Blanksby, Michelle L. Coote

Faculty of Science, Medicine and Health - Papers: part A

In most radicals the singly occupied molecular orbital (SOMO) is the highest-energy occupied molecular orbital (HOMO); however, in a small number of reported compounds this is not the case. In the present work we expand significantly the scope of this phenomenon, known as SOMO–HOMO energy-level conversion, by showing that it occurs in virtually any distonic radical anion that contains a sufficiently stabilized radical (aminoxyl, peroxyl, aminyl) non-π-conjugated with a negative charge (carboxylate, phosphate, sulfate). Moreover, regular orbital order is restored on protonation of the anionic fragment, and hence the orbital configuration can be switched by pH. Most importantly, our theoretical …

Five Practical Uses Of Spatial Autocorrelation For Studies Of Coral Reef Ecology, S Hamylton

Faculty of Science, Medicine and Health - Papers: part A

The organisation of benthic communities across coral reefs is underpinned by spatially structured ecological processes and neighbourhood interactions such as larval dispersal, migration, competition and the spread of disease. These give rise to spatial autocorrelation in reef communities. This paper demonstrates how the measurement of spatial autocorrelation can profitably be incorporated into studies of coral reef ecology through a series of 5 simple statistical exercises: for the generation of maps depicting the strength of spatial relationships between ecological communities, as an indicator of optimal dimensions for sampling ecological communities on coral reefs, as a diagnostic tool for model misspecification, as …

Biofabrication: An Overview Of The Approaches Used For Printing Of Living Cells, Cameron J. Ferris, Kerry G. Gilmore, Gordon G. Wallace, Marc In Het Panhuis

Faculty of Science, Medicine and Health - Papers: part A

The development of cell printing is vital for establishing biofabrication approaches as clinically relevant tools. Achieving this requires bio-inks which must not only be easily printable, but also allow controllable and reproducible printing of cells. This review outlines the general principles and current progress and compares the advantages and challenges for the most widely used biofabrication techniques for printing cells: extrusion, laser, microvalve, inkjet and tissue fragment printing. It is expected that significant advances in cell printing will result from synergistic combinations of these techniques and lead to optimised resolution, throughput and the overall complexity of printed constructs.

Carbon Dioxide Rebreathing In Respiratory Protective Devices: Influence Of Speech And Work Rate In Full-Face Masks, Carmen L. Smith, Jane L. Whitelaw, Brian Davies

Faculty of Science, Medicine and Health - Papers: part A

Carbon dioxide (CO2) rebreathing has been recognised as a concern regarding respirator use and is related to symptoms of discomfort, fatigue, dizziness, headache, muscular weakness and drowsiness. Previous investigations are limited by small sample size and have not evaluated the relationship between CO2 inhalation and phonic respiration (breathing during speech) in respiratory protective devices (RPDs). A total of 40 workers trained in the use of RPDs performed a graded exercise test on a cycle ergonometer that increased in workload every 5 min. During the third minute of each stage, participants read aloud a prepared text. Measures of mixed expired CO2 …

Diversifying Ethnicity In Australia's Population And Environment Debates, Natascha Klocker, Lesley Head

Faculty of Science, Medicine and Health - Papers: part A

Population–environment debates in Australia are at an impasse. While the ability of this continent to sustain more migrants has attracted persistent scrutiny, nuanced explorations of diverse migrant cultures and their engagements with Australian landscapes have scarcely begun. Yet as we face the challenges of a climate changing world we would undoubtedly benefit from the most varied knowledges we can muster. This paper brings together three arenas of environmental debate circulating in Australia—the immigration/carrying capacity debate, comparisons between Indigenous and Anglo-European modes of environmental interaction, and research on household sustainability dilemmas—to demonstrate the exclusionary tendencies of each. We then attempt to …

Welcome To Bogan-Ville: Reframing Class And Place Through Humour, Chris Gibson

Faculty of Science, Medicine and Health - Papers: part A

On August 4, 2009, Australian online news commentary website the Punch announced that Albion Park, in the Australian industrial city of Wollongong, was one of the nation's top ten “most bogan” places. This paper explores what it means to be bogan in Australia, tracing historical antecedents, local debate at the time of this media event, and the manner in which the politics of class and place identity are negotiated through humour. Some local residents railed against associations with “lower-class” culture or feared damaged reputations for their neighbourhoods; others responded in sometimes unexpected and creative ways—through humour, and by claiming bogan …

Effects Of Atmospheric Light Scattering On Spectroscopic Observations Of Greenhouse Gases From Space. Part 2: Algorithm Intercomparison In The Gosat Data Processing For Co2 Retrievals Over Tccon Sites, Sergey Oshchepkov, Andrey Bril, Tatsuya Yokota, Paul O. Wennberg, Nicholas M. Deutscher, Debra Wunch, Geoffrey C. Toon, Yukio Yoshida, Christopher W. O'Dell, David Crisp, Charles E. Miller, Christian Frankenberg, Andre Butz, Ilse Aben, Sandrine Guerlet, Otto Hasekamp, Hartmut Boesch, Austin Cogan, Robert Parker, David Griffith, Ronald Macatangay, Justus Notholt, Ralf Sussmann, Markus Rettinger, Vanessa Sherlock, John Robinson, Esko Kyro, Pauli Heikkinen, Dietrich G. Feist, Isamu Morino, Nikolay Kadygrov, Dmitry Belikov, Shamil Maksyutov, Tsuneo Matsunaga, Osamu Uchino, Hiroshi Watanabe

Faculty of Science, Medicine and Health - Papers: part A

This report is the second in a series of companion papers describing the effects of atmospheric light scattering in observations of atmospheric carbon dioxide (CO2) by the Greenhouse gases Observing SATellite (GOSAT), in orbit since 23 January 2009. Here we summarize the retrievals from six previously published algorithms; retrieving column-averaged dry air mole fractions of CO2 (XCO2) during 22 months of operation of GOSAT from June 2009. First, we compare data products from each algorithm with ground-based remote sensing observations by Total Carbon Column Observing Network (TCCON). Our GOSAT-TCCON coincidence criteria select satellite observations within a 5° radius of 11 …

Dinosaur Lactation?, Paul L. Else

Faculty of Science, Medicine and Health - Papers: part A

Lactation is a process associated with mammals, yet a number of birds feed their newly hatched young on secretions analogous to the milk of mammals. These secretions are produced from various sections (crop organ, oesophageal lining and proventriculus) of the upper digestive tract and possess similar levels of fat and protein, as well as added carotenoids, antibodies and, in the case of pigeons and doves, epidermal growth factor. Parental care in avian species has been proposed to originate from dinosaurs. This study examines the possibility that some dinosaurs used secretory feeding to increase the rate of growth of their young, …

Sequential Extraction Procedures For The Determination Of Phosphorus Forms In Sediment, Changyou Wang, Yong Zhang, Hongli Li, R John Morrison

Faculty of Science, Medicine and Health - Papers: part A

This article summarizes the main extraction methods for sedimentary phosphorus (P) determination. With sequential chemical extractions, P is supposed to be selectively removed from different compounds in the sediments. Extraction schemes using strong acids and alkaline solutions have been tested on different sediments and found not to extract well-defined fractions. In addition, several systematic errors in these schemes have been detected. Thus, these schemes have been modified and simplified accordingly. The Standards Measurements and Testing Program of the European Commission (SMT) method is a popular modification of these extraction schemes, as it is simple to handle, allows laboratories to achieve …

Single Molecule Characterization Of The Interactions Between Amyloid-Β Peptides And The Membranes Of Hippocampal Cells, Priyanka Narayan, Kristina A. Ganzinger, James Mccoll, Laura Weimann, Sarah Meehan, Seema Qamar, John A. Carver, Mark R. Wilson, Peter St George-Hyslop, Christopher M. Dobson, David Klenerman

Faculty of Science, Medicine and Health - Papers: part A

Oligomers of the 40 and 42 residue amyloid-β peptides (Aβ40 and Aβ42) have been implicated in the neuronal damage and impaired cognitive function associated with Alzheimer’s disease. However, little is known about the specific mechanisms by which these misfolded species induce such detrimental effects on cells. In this work, we use single-molecule imaging techniques to examine the initial interactions between Aβ monomers and oligomers and the membranes of live cells. This highly sensitive method enables the visualization of individual Aβ species on the cell surface and characterization of their oligomerization state, all at biologically relevant, nanomolar concentrations. The results indicate …

Maternal Obesity Is Associated With The Formation Of Small Dense Ldl And Hypoadiponectinemia In The Third Trimester, Barbara J. Meyer, Frances M. Stewart, Elizabeth A. Brown, Josephine Cooney, Solveig Nilsson, Gunilla Olivecrona, Jane E. Ramsay, Bruce A. Griffin, Muriel J. Caslake, Dilys J. Freeman

Faculty of Science, Medicine and Health - Papers: part A

CONTEXT: Maternal obesity is associated with high plasma triglyceride, poor vascular function, and an increased risk for pregnancy complications. In normal-weight pregnant women, higher triglyceride is associated with increased small, dense low-density lipoprotein (LDL). HYPOTHESIS: In obese pregnancy, increased plasma triglyceride concentrations result in triglyceride enrichment of very low-density lipoprotein-1 particles and formation of small dense LDL via lipoprotein lipase. DESIGN: Women (n = 55) of body mass index of 18-46 kg/m(2) were sampled longitudinally at 12, 26, and 35 weeks' gestation and 4 months postnatally. SETTING: Women were recruited at hospital antenatal appointments, and study visits were in a …

Food Synergy: The Key To A Healthy Diet, David R. Jacobs Jr, Linda C. Tapsell

Faculty of Science, Medicine and Health - Papers: part A

Food synergy is the concept that the non-random mixture of food constituents operates in concert for the life of the organism eaten and presumably for the life of the eater. Isolated nutrients have been extensively studied in well-designed, long-term, large randomised clinical trials, typically with null and sometimes with harmful effects. Therefore, although nutrient deficiency is a known phenomenon, serious for the sufferer, and curable by taking the isolated nutrient, the effect of isolated nutrients or other chemicals derived from food on chronic disease, when that chemical is not deficient, may not have the same beneficial effect. It appears that …

Synthesis, Characterization, And Photophysics Of Oxadiazole- And Diphenylaniline-Substituted Re(I) And Cu(I) Complexes, Raphael Horvath, Michael G. Fraser, Scott A. Cameron, Allan G. Blackman, Pawel Wagner, David L. Officer, Keith C. Gordon

Faculty of Science, Medicine and Health - Papers: part A

Transition-metal complexes of the types [Re(CO)3Cl(NN)], [Re(CO)3py(NN)]+, and [Cu(PPh3)2(NN)]+, where NN = 4,4′-bis(5-phenyl-1,3,4-oxadiazol-2-yl)-2,2′-bipyridine (OX) and 4,4′-bis(N,N-diphenyl-4-[ethen-1-yl]-aniline)-2,2′-bipyridine (DPA), have been synthesized and characterized. Crystal structures for [Re(CO)3Cl(DPA)] and [Cu(PPh3)2(OX)]BF4 are presented. The crystal structure of the rhenium complex shows a trans arrangement of the ethylene groups, in agreement with density functional theory calculations. The structure of the copper complex displays the planar aromatic nature of the bpy–oxadiazole ligand. Density functional theory modeling of the complexes was supported by comparison of calculated and experimental normalized Raman spectra; the mean absolute deviations of the complexes were <10 cm–1. The Franck–Condon state was investigated using UV–vis and resonance Raman spectroscopic as well as density functional theory computational techniques. It was shown that the lowest energy absorption peaks are metal to ligand charge transfer and ligand-centered charge transfer for the oxadiazole- and diphenylaniline-substituted bipyridine ligands, respectively. The lowest energy excited states were characterized using transient emission and absorption spectroscopic techniques in conjunction with density functional theory calculations. These showed that the DPA complexes had ligand-centered nonemissive “dark” states with lifetimes ranging from 300 to 2000 ns.

Concise Synthesis Of Α-Substituted 2-Benzofuranmethamines And Other 2-Subsituted Benzofurans Via Α-Substituted 2-Benzofuranmethyl Carbocation Intermediates, Nikhom Wongsa, Ubonta Sommart, Thunwadee Ritthiwigrom, Arife Yazici, Somdej Kanokmedhakul, Kwanjai Kanokmedhakul, Anthony C. Willis, Stephen G. Pyne

Faculty of Science, Medicine and Health - Papers: part A

Propargyl amines 4, where R3 is aryl, undergo 5-exo-dig cyclization reactions under relatively mild conditions (AgNO3, DMF, 60 °C, 1 h) to give 3-amino-2,3-dihydro-2-arylmethylidenebenzofurans 5 (R3 = aryl). In contrast, substrates where R3 is alkyl undergo competing 6-endo-dig and 5-exo-dig cyclization processes. The hydroxymethyl substrate 4 (R3 = CH2OH), however, was smoothly converted to its corresponding 5-exo-dig cyclization product 5, likely due to the assistance of the primary hydroxyl group in the 5-exo-dig cyclization process by silver cation coordination. Under more enforcing conditions (AgNO3, DMF, 100 °C, 18 h), the initially formed products 5 undergo a 1,3-allylic rearrangement to their …

Bottles, Bores, And Boats: Agency Of Water Assemblages In Post/Colonial Inland Australia, Leah Maree Gibbs

Faculty of Science, Medicine and Health - Papers: part A

Australian water politics is marked by conceptual and bureaucratic separation of water as discrete matter. The source of this politics of separation is colonial relations with water and the Australian continent. Yet, analysis of the materiality of water illuminates the agency of water as part of an assemblage. This paper seeks to unsettle the treatment of water as separate, discrete matter. It asks how political responses to the public problem of water would change were we to take seriously the vitality of nonhuman bodies. In order to investigate this question, the paper presents an analysis of six objects from the …

Does Health Capital Have Differential Effects On Economic Growth?, Arusha V. Cooray

Faculty of Commerce - Papers (Archive)

Investigating the impact of health capital disaggregated by gender on economic growth in a sample of 210 countries over the 1990-2008 period, this study suggests that the influence of health capital across countries cannot be generalised. Results for the full sample indicate that health capital does not have a robust and significant effect on economic growth unless through their interactions with health expenditure and education. The results disaggregated by income group reveal that health capital has a positive robust influence on economic growth in high and upper middle income economies. In low and low middle income economies, health capital gains …

Are Low-Skill Public Sector Workers Really Overpaid? A Quasi-Differenced Panel Data Analysis, Peter Siminski

Faculty of Commerce - Papers (Archive)

Public–private sectoral wage differentials have been studied extensively using quantile regression techniques. These typically find large public sector premiums at the bottom of the wage distribution. This may imply that low skill workers are ‘overpaid’, prompting concerns over efficiency. We note several other potential explanations for this result and explicitly test whether the premium varies with skill, using Australian data. We use a quasi-differenced Generalized Method of Moments (GMM) panel data model which has not been previously applied to this topic, internationally. Unlike other available methods, this technique identifies sectoral differences in returns to unobserved skill. It also facilitates a …

Careers And Organisational Objectives: Managing Competing Interests In Cooperative Research Centres, Sam Garrett-Jones, Tim Turpin, Kieren Diment

Faculty of Commerce - Papers (Archive)

Research of potential socio-economic value is often conducted within cross-sector (government, university, business) centres. There has been growing interest among science policy researchers in seeking to understand the organizational dilemmas confronted in cross-sector research collaboration. While there is clearly a coalition of interests among partners engaged with collaborative research their broader organizational objectives and strategies may converge, diverge, or even compete. Yet little empirical evidence exists on (a) how individual researchers perceive the benefits of their participation, (b) how far the structures and functions of particular collaborative R&D centres coalesce around of researchers’ expectations and, (c) what problems arise for …

A Template For Integrated Reporting, Indra Abeysekera

Faculty of Commerce - Papers (Archive)

Purpose – This paper sets out to outline the concept of integrated reporting and to propose a template for integrated reporting in organisations.

Design/methodology/approach – The approach to the conceptual model is founded on concepts proposed on integrated reporting by the King Report on Governance for South Africa (King III), and the International Integrated Reporting Council in the U.K.

Findings – The integrated report should explain the story of reaching the organisation’s vision, underpinned by its values, enacted by management, monitored by governance, and using facets of resources relating to financial capital, intellectual capital, social capital, and environmental capital.

Practical …

Innovation And Economic Education: An Integration, Eduardo Pol

Faculty of Commerce - Papers (Archive)

Almost everyone agrees on the importance of educating a broad spectrum of the public about economics and business. It has been suggested by experts in economic education that universities should place greater emphasis on economics as a general education. The present paper develops a proposal to integrate innovation into elementary economic education that business faculties might use to enrich their general economic education offerings. We believe the proposal can be implemented through the design of a new subject - which may be called the 'Creative Economy' - supported by a method of teaching and learning by successive approximations. The study …

Metacapitalism Vs Healthcare, Sanja Pupovac, George M. Mickhail

Faculty of Commerce - Papers (Archive)

The aim of this paper is to critically examine the effect of the MetaCapitalism strategy changes on Australian healthcare sector companies during the period 1989-2007, and to establish whether there is any relationship between those changes and any adverse corporate consequences, such as: corporate collapses, acquisitions, mergers, delisting from the ASX 200. The main rationale behind the MetaCapitalism strategy, is that by aggressively reducing physical assets, outsourcing production and downsizing of the workforce, then firms will become at the same time efficient and profitable through participating in this highly competitive technological era. However, this uninhibited pursuit of efficiency by corporations …

Does The Interest Rate For Business Loans Respond Asymmetrically To Changes In The Cash Rate?, Abbas Valadkhani, Amir Arjomandi, Martin J. O'Brien

Faculty of Commerce - Papers (Archive)

This article examines the dynamic relationship between the Reserve Bank of Australia's (RBA's) cash rate and the variable interest rate for lending to small businesses. The relationship is evaluated via an asymmetric GARCH model using monthly data spanning from August 1990 to October 2012. Our results show that a 1 percentage point increase in the cash rate results in an instantaneous 1.086 percentage point rise in the variable rate for small businesses, whereas an equivalent 1 percentage point cut only leads to a 0.862 percentage point fall with a delay of up to 2 months. This outcome has obvious implications …

Extending The Use Of Market Orientation: Transforming A Charity Into A Business, Paul A. Chad

Faculty of Commerce - Papers (Archive)

Charities play a crucial role within society but are facing growing competition. Adopting a market orientation assists for-profit organisations to improve performance and can potentially also assist charities. This paper examines the under-researched topic of how market orientation can be appropriately introduced into a charity, and the resultant effect upon performance. A charity that introduced market orientation is examined using a discourse transformation framework. Thematic analysis of in-depth interviews of employees identifies how management changed the organisation through use of a three-phase process of new managerialism, professionalism and embedding. Few if any papers have previously examined how management of a …

Application Of The Task-Technology Fit Model To Structure And Evaluate The Adoption Of E-Books By Academics, John D'Ambra, Concepcion S. Wilson, Shahriar Akter

Faculty of Commerce - Papers (Archive)

Increasingly, e-books are becoming alternatives to print books in academic libraries, thus providing opportunities to assess how well the use of e-books meets the requirements of academics. This study uses the task-technology fit (TTF) model to explore the interrelationships of e-books, the affordances offered by smart readers, the information needs of academics, and the "fit" of technology to tasks as well as performance. We propose that the adoption of e-books will be dependent on how academics perceive the fit of this new medium to the tasks they undertake as well as what added-value functionality is delivered by the information technology …

Transmembrane Domain Nrg1 Mutant Mice Show Altered Susceptibility To The Neurobehavioural Actions Of Repeated Thc Exposure In Adolescence, Leonora E. Long, Rose Chesworth, Xu-Feng Huang, Iain S. Mcgregor, Jonathon C. Arnold, Tim Karl

Faculty of Health and Behavioural Sciences - Papers (Archive)

Heavy cannabis abuse increases the risk of developing schizophrenia. Adolescents appear particularly vulnerable to the development of psychosis-like symptoms after cannabis use. To test whether the schizophrenia candidate gene neuregulin 1 (NRG1) modulates the effects of cannabinoids in adolescence, we tested male adolescent heterozygous transmembrane domain Nrg1 mutant (Nrg1 TM HET) mice and wild type-like littermates (WT) for their neurobehavioural response to repeated Δ⁹-tetrahydrocannabinol (THC, 10 mg/kg i.p. for 21 d starting on post-natal day 31). During treatment and 48 h after treatment withdrawal, we assessed several behavioural parameters relevant to schizophrenia. After behavioural testing we measured autoradiographic …