Social and Behavioral Sciences Commons^™

Opioid Use And Harms Associated With A Sustained-Release Tapentadol Formulation: A Postmarketing Study Protocol, Amy Peacock, Briony K. Larance, Michael P. Farrell, Rose Cairns, Nicholas A. Buckley, Louisa Degenhardt

Faculty of Social Sciences - Papers (Archive)

Introduction It has been argued that tapentadol may pharmacologically have lower abuse potential than other pharmaceutical opioids currently available. However, there has been no comprehensive triangulation of data regarding use and harms associated with this formulation. A sustained-release formulation (SRF) of tapentadol (Palexia) was released in Australia in 2011 and listed for public subsidy in 2013. We summarise here the methods of a postmarketing study which will measure postintroduction: (1) population level availability, (2) extramedical use and diversion, (3) attractiveness for extramedical use and (4) associated harms, of tapentadol compared against other pharmaceutical opioids. Methods and analysis We evaluated key …

Factors Associated With Under-Five Mortality In Bhutan: An Analysis Of The Bhutan National Health Survey 2012, Tashi Dendup, Yun Zhao, Deki Dema

Faculty of Social Sciences - Papers (Archive)

Background: As an important marker for health equity and access, under-five mortality (UFM) is a primary measure for socioeconomic development. The importance of reducing UFM has been further emphasized in an ambitious target under Sustainable Development Goals. The factors influencing UFM are not adequately understood in Bhutan. Methods: The most recent dataset of the Bhutan National Health Survey (BNHS) 2012 was used in this study. Multiple logistic regression analysis using a backwards elimination approach was performed to identify significant factors influencing UFM. All statistical analyses were adjusted for the complex study design due to the multistage stratified cluster sampling used …

Is More Area-Level Crime Associated With More Sitting And Less Physical Activity? Longitudinal Evidence From 37,162 Australians, Thomas E. Astell-Burt, Xiaoqi Feng, Gregory S. Kolt, Bin Jalaludin

Faculty of Social Sciences - Papers (Archive)

Does a rise in crime result in increased sitting time and a reduction in physical activity? We used unobserved (“fixed”)-effects models to examine associations between change in objectively measured crime (nondomestic violence, malicious damage, breaking and entering, and stealing, theft, and robbery) in Australia and measures of sitting time, walking, and moderate-to-vigorous physical activity (MVPA) in a residentially stable sample of 17,474 men and 19,688 women at baseline (2006–2008) and follow-up (2009–2010). Possible sources of time-varying confounding included age, income, economic status, relationship (couple) status, and physical functioning. In adjusted models, an increase in all crimes of 10 counts per …

Food Insecurity And Poor Diet Quality Are Associated With Reduced Quality Of Life In Older Adults, Joanna C. Russell, Victoria M. Flood, Heather Yeatman, Jie Jin Wang, Paul Mitchell

Faculty of Social Sciences - Papers (Archive)

Aim: The aim of this study was to examine the relationships of food security and diet quality with health related quality of life (HRQoL) in a cohort of older Australians. Methods: Data were collected as part of the Blue Mountains Eye Study, a cohort study of community-living individuals aged 49 years and over. A 12-item food security survey, the Short-form 36-item (SF-36) health survey, assessing four physical and four mental domains of HRQoL, and a food frequency questionnaire (FFQ) were completed by 2642 participants. The Total Diet Score (TDS) (maximum score 20) measured diet quality based on food intake from …

Factors Associated With The Development Of Depression In Chronic Non-Cancer Pain Patients Following The Onset Of Opioid Treatment For Pain, Kimberley Smith, Richard P. Mattick, Raimondo Bruno, Suzanne Nielsen, Milton Cohen, Gabrielle Campbell, Briony K. Larance, Michael P. Farrell, Louisa Degenhardt

Faculty of Social Sciences - Papers (Archive)

Background and aims Pharmaceutical opioid prescription rates are increasing globally, however knowledge of their long-term effects on mental health, in particular depression remains limited. This study aimed to identify factors associated with the onset of depression post-opioid use that differ to factors associated with depression post-pain. Method Participants (N=1 418) were a national sample prescribed opioids for chronic non-cancer pain. Age at onset of depression, pain and commencement of opioid medications were collected via structured interview. Results Six in 10 (61%) reported lifetime depression; of those, almost half developed depression after pain and after they started opioid medications (48%). Variables …

The Effects Associated With New Public Management-Inspired Change Within Juvenile Justice In New South Wales, Ann Dadich, Brian Stout, Hassan Hosseinzadeh

Faculty of Social Sciences - Papers (Archive)

This study is the first to examine reactions to, and the management of organisational change within the juvenile justice sector through the public administration lens. This is achieved via a state-wide study on the introduction of a policy framework in eight juvenile justice centres to manage detainee behaviour. Data on centre demographics, framework implementation, and associated outcomes were analysed. Despite the common framework, the eight centres reacted to, and managed organisational change in disparate ways with disparate effects - some of which appear counterintuitive. These findings demonstrate the ways in which organisational context shapes reactions to, and the management of …

Reconnecting Urban Planning With Health: A Protocol For The Development And Validation Of National Liveability Indicators Associated With Noncommunicable Disease Risk Behaviours And Health Outcomes, Billie Giles-Corti, Hannah M. Badland, Suzanne Mavoa, Gavin Turrell, Fiona Bull, Bryan Boruff, Christopher Pettit, Adrian E. Bauman, Paula Hooper, Karen Villanueva, Thomas Astell-Burt, Xiaoqi Feng, Vincent Learnihan, R Davey, Rob Grenfell, Sarah Thackway

Faculty of Social Sciences - Papers (Archive)

Aim: Liveable communities create the conditions to optimise health and wellbeing outcomes in residents by influencing various social determinants of health - for example, neighbourhood walkability and access to public transport, public open space, local amenities, and social and community facilities. This study will develop national liveability indicators that are (a) aligned with state and federal urban policy, (b) developed using national data (where available), (c) standard and consistent over time, (d) suitable for monitoring progress towards creating more liveable, equitable and sustainable communities, (e) validated against selected noncommunicable disease risk behaviours and/or health outcomes, and (f) practical for measuring …

A Functional Polymorphism Of The Maoa Gene Is Associated With Neural Responses To Induced Anger Control, Thomas F. Denson, Carol Dobson-Stone, Richard Ronay, William Von Hippel, Mark M. Schira

Faculty of Social Sciences - Papers (Archive)

Aggressiveness is highly heritable. Recent experimental work has linked individual differences in a functional polymorphism of the monoamine oxidase-A gene (MAOA) to anger-driven aggression. Other work has implicated the dorsal ACC (dACC) in cognitive-emotional control and the amygdala in emotional arousal. The present imaging genetics study investigated dACC and amygdala reactivity to induced anger control as a function of MAOA genotype. A research assistant asked 38 healthy male undergraduates to control their anger in response to an insult by a rude experimenter. Men with the low-expression allele showed increased dACC and amygdala activation after the insult, but men with the …

A Randomized Controlled Trial Investigating The Neurocognitive Effects Of Lacprodan® Pl-20, A Phospholipid-Rich Milk Protein Concentrate, In Elderly Participants With Age-Associated Memory Impairment: The Phospholipid Intervention For Cognitive Ageing Reversal (Plicar): Study Protocol For A Randomized Controlled Trial, Andrew B. Scholey, David A. Camfield, Matthew E. Hughes, Will Woods, Con K. Stough, David J. White, Shakuntla V. Gondalia, Pernille D. Frederiksen

Faculty of Social Sciences - Papers (Archive)

Background: Age-related cognitive decline (ARCD) is of major societal concern in an ageing population, with the development of dietary supplements providing a promising avenue for amelioration of associated deficits. Despite initial interest in the use of phospholipids (PLs) for ARCD, in recent years there has been a hiatus in such research. Because of safety concerns regarding PLs derived from bovine cortex, and the equivocal efficacy of soybean-derived PLs, there is an important need for the development of new PL alternatives. Phospholipids derived from milk proteins represent one potential candidate treatment.

Methods: In order to reduce the effects of age-associated memory …

Is Quality Of Diet Associated With The Microvasculature? An Analysis Of Diet Quality And Retinal Vascular Calibre In Older Adults, Bamini Gopinath, Victoria M. Flood, Jie Jin Wang, Elena Rochtchina, Tien Y. Wong, Paul Mitchell

Faculty of Social Sciences - Papers (Archive)

It is unknown whether diet quality is associated with microvascular structure. The present study aimed to investigate the relationship between diet quality, reflecting adherence to dietary guidelines, with retinal microvascular calibre in older adults. The dietary data of 2720 Blue Mountains Eye Study participants, aged 50þ years, were collected using a semi-quantitative FFQ. A modified version of the Healthy Eating Index for Australians was developed to determine total diet scores (TDS). Fundus photographs were taken and retinal vascular calibre measured using computer-assisted techniques and summarised. After adjusting for age, sex, BMI, mean arterial blood pressure, smoking, serum glucose, leucocyte count …

Project Good News - Engaging Priority Cald Communities To Reduce The Stigma Associated With Cancer, Lyn Phillipson, Julie Hall, Leissa Pitts, Tara Hunt

Faculty of Social Sciences - Papers (Archive)

Abstract presented at the Innovations in Cancer Services and Care NSW Conference 2013

Short Sleep Duration Is Associated With Risk Of Future Diabetes But Not Cardiovascular Disease: A Prospective Study And Meta-Analysis, E G. Holliday, Christopher A. Magee, Leonard Kritharides, Emily Banks, John Attia

Faculty of Social Sciences - Papers (Archive)

Epidemiologic studies have observed association between short sleep duration and both cardiovascular disease (CVD) and type 2 diabetes, although these results may reflect confounding by pre-existing illness. This study aimed to determine whether short sleep duration predicts future CVD or type 2 diabetes after accounting for baseline health. Baseline data for 241,949 adults were collected through the 45 and Up Study, an Australian prospective cohort study, with health outcomes identified via electronic database linkage. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals. Compared to 7h sleep, <6h sleep was associated with incident CVD in participants reporting ill-health at baseline (HR=1·38 [95% CI: 1·12-1·70]), but not after excluding those with baseline illness and adjusting for baseline health status (1·03 [0·88-1·21]). In contrast, the risk of incident type 2 diabetes was significantly increased in those with <6h versus 7h sleep, even after excluding those with baseline illness and adjusting for baseline health (HR=1·29 [1·08-1·53], P=0.004). This suggests the association is valid and does not simply reflect confounding or reverse causation. Meta-analysis of ten prospective studies including 447,124 participants also confirmed an association between short sleep and incident diabetes (1·33 [1·20-1·48]). Obtaining less than 6 hours of sleep each night (compared to 7 hours) may increase type 2 diabetes risk by approximately 30%.

Community-Based Child Abuse Prevention: Outcomes Associated With A Differential Response Program In California, Amy Conley Wright, Jill Duerr Berrick

Faculty of Social Sciences - Papers (Archive)

Traditionally, the American child welfare system intervenes in cases of evident and severe maltreatment. Families in need of help, but who have not reached a crisis, are excluded from typical services. Some suggest that if these families were served, few would be rereferred to the child welfare system. California's Differential Response (DR) has three tracks, of which ''Track 1'' targets families screened out of child protective services (CPS) and refers them to agencies that provide voluntary, home-based services and referrals. This study examined child-welfare trajectories for families receiving Track 1 DR services in one California county. Using survival analysis, treatment …

Early Coital Debut And Associated Hiv Risk Factors Among Young Women And Men In South Africa, Audrey Pettifor, Katie O'Brien, Catherine L. Mac Phail, William Miller, Helen Rees

Faculty of Social Sciences - Papers (Archive)

CONTEXT Young people in South Africa are at high risk of HIV infection. Because first sexual experiences may influence a young person's HIV risk, a better understanding of coital debut is needed. METHODS Data from a nationally representative survey that included 7,692 sexually active South African youth aged 15-24 were used to assess characteristics related to sexual debut and to respondents' first sexual partner. Poisson regression analyses were conducted to identify relationships among these characteristics and partner age differences, early coital debut (i.e., before age 15), forced sex with one's first partner and nonuse of condoms at first sex. RESULTS …

Community-Based Child Abuse Prevention: Outcomes Associated With A Differential Response Program In California, Amy Conley Wright

Faculty of Social Sciences - Papers (Archive)

Presented at the 17th National Conference on Child Abuse and Neglect on April 2, 2009.

Beta-Glucans In The Treatment Of Diabetes And Associated Cardiovascular Risks, Jiezhong Chen, Kenneth Raymond

Faculty of Social Sciences - Papers (Archive)

Diabetes mellitus is characterized by high blood glucose level with typical manifestations of thirst, polyuria, polydipsia, and weight loss. It is caused by defects in insulin-mediated signal pathways, resulting in decreased glucose transportation from blood into muscle and fat cells. The major risk is vascular injury leading to heart disease, which is accelerated by increased lipid levels and hypertension. Management of diabetes includes: control of blood glucose level and lipids; and reduction of hypertension. Dietary intake of beta-glucans has been shown to reduce all these risk factors to benefit the treatment of diabetes and associated complications. In addition, beta-glucans also …

Factors Associated With Self-Efficacy For Condom Use And Sexual Negotiation Among South African Youth, Jennifer Sayles, Audrey Pettifor, Mitchell D. Wong, Catherine L. Mac Phail, Sung-Jae Lee, Ellen Hendriksen, Helen Rees, Thomas Coates

Faculty of Social Sciences - Papers (Archive)

Objectives: To use logistic regression modeling to identify factors associated with high self-efficacy for sexual negotiation and condom use in a sample of South African youth. Methods: The Reproductive Health and HIV Research Unit (RHRU) National Youth Survey examined a nationally representative sample of 7409 sexually active South African youth aged 15 to 24 years. We used logistic regression modeling in this sample to identify factors associated with the main outcome of high self-efficacy. Results: Among female respondents (n = 3890), factors associated with high self-efficacy in the adjusted model were knowing how to avoid HIV (odds ratio [OR] = …

Environmental Factors Associated With Adults' Participation In Physical Activity: A Review, Nancy Humpel, Neville Owen, Eva Leslie

Faculty of Social Sciences - Papers (Archive)

Background: Promoting physical activity is a public health priority, and changes in the environmental contexts of adults’ activity choices are believed to be crucial. However, of the factors associated with physical activity, environmental influences are among the least understood. Method: Using journal scans and computerized literature database searches, we identified 19 quantitative studies that assessed the relationships with physical activity behavior of perceived and objectively determined physical environment attributes. Findings were categorized into those examining five categories: accessibility of facilities, opportunities for activity, weather, safety, and aesthetic attributes. Results: Accessibility, opportunities, and aesthetic attributes had significant associations with physical activity. …