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Social and Behavioral Sciences Commons™
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Full-Text Articles in Social and Behavioral Sciences
Stress-Induced Retrotranslocation Of Clusterin/Apoj Into The Cytosol, P Nizard, Suzanne Tetley, Y Le Drean, T Watrin, P Le Goff, Mark R. Wilson, Denis Michel
Stress-Induced Retrotranslocation Of Clusterin/Apoj Into The Cytosol, P Nizard, Suzanne Tetley, Y Le Drean, T Watrin, P Le Goff, Mark R. Wilson, Denis Michel
Faculty of Science - Papers (Archive)
Clusterin is a usually secreted glycoprotein with chaperone properties. Recently, it has been suggested that clusterin isoforms reside in the nuclear and cytosolic compartments of human cell types, where they can influence various cellular programs including DNA repair, transcription and apoptosis. Several mechanisms have been proposed to explain this atypical location, including alternative transcription initiation and alternative splicing. However none of these have been unequivocally established as occurring in live cells. Here we provide direct experimental evidence that in live intact cells, under certain stress conditions, clusterin can evade the secretion pathway and reach the cytosol. This was demonstrated using …
Get Into The Groove: The Role Of Sound In Generating A Sense Of Belonging In Street Parades, Michelle Duffy, Gordon R. Waitt, Christopher R. Gibson
Get Into The Groove: The Role Of Sound In Generating A Sense Of Belonging In Street Parades, Michelle Duffy, Gordon R. Waitt, Christopher R. Gibson
Faculty of Science - Papers (Archive)
Research undertaken in a range of fields has sought to understand the significance of sound and the processes of listening in making sense of social worlds. This inherently interdisciplinary pursuit has particularly emerged in sociology cultural geography, cultural studies, musicology and music therapy. Yet, a great deal is still not known about the interplays between music, sounds, spaces, bodies and our sense of self