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Full-Text Articles in Social and Behavioral Sciences
Water Quality Assessment - Issues From A Laboratory Management Perspective, Robert John Morrison, Mark R. O'Donnell, D. Springer
Water Quality Assessment - Issues From A Laboratory Management Perspective, Robert John Morrison, Mark R. O'Donnell, D. Springer
Faculty of Science - Papers (Archive)
This paper considers issues relating to the measurement of water quality parameters in the laboratory, especially an external (usually commercial) laboratory. Many organisations now use testing laboratories for water quality measurements, a process that has advantages and some limitations. The interaction between the testing laboratory and the organization requiring the data is crucial, and this paper looks at some aspects where a full appreciation of the role of each partner is important. These include limits of detection and reporting, measurement uncertainty, sample storage and preservation times, and various quality control procedures.
Synthesis Of Novel 3'-Spirocyclic-Oxindole Derivatives And Assessment Of Their Cytostatic Activities, Sarah Yong, Alison T. Ung, Stephen G. Pyne, Brian W. Skelton, Allan H. White
Synthesis Of Novel 3'-Spirocyclic-Oxindole Derivatives And Assessment Of Their Cytostatic Activities, Sarah Yong, Alison T. Ung, Stephen G. Pyne, Brian W. Skelton, Allan H. White
Faculty of Science - Papers (Archive)
The synthesis of some novel 3′-spirocyclic-oxindole compounds, based on the spiro[indole-3,5′-isoxazolidin]-2(1H)-one, the 2′H-spiro[indole-3,6′-[1,3]oxazinane]-2,2′(1H)-dione and the 2′H-spiro[indoline-3,3′-pyrrolo[1,2-c][1,3′]oxazine]-1′,2(1H)-dione heterocyclic structures, is described. These compounds were prepared from methyl α-(2-nitrophenyl)acrylate via [1,3]-dipolar cycloaddition reactions with two acyclic nitrones and one cyclic nitrone followed by reduction of the cycloadducts and then treatment with triphosgene. Two of these compounds showed significant cytostatic activity on three cancer cell lines with GI50 values of 2.6–4.1 μM on the human breast cancer cell line, MCF-7.