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Social and Behavioral Sciences Commons™
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Full-Text Articles in Social and Behavioral Sciences
Sex Differences In Differential Fear Conditioning During The Acquisition And Consolidation Of Learned Safety, David Sylvan Reis
Sex Differences In Differential Fear Conditioning During The Acquisition And Consolidation Of Learned Safety, David Sylvan Reis
Theses and Dissertations
The ability to distinguish between threatening and non-threatening situations requires careful regulation of behavioral and physiological responses to stress and fear. Deficits in fear regulation are maladaptive and can lead to the development of anxiety disorders such as PTSD. Women are nearly twice as likely to develop PTSD as are men and laboratory animal studies have shown facilitated fear acquisition, resistance to fear extinction, deficits in extinction retention and impaired discrimination between danger and safety cues in females. Taken together this suggests a propensity for reduced inhibitory control over fear responding in females. Here we investigate the mechanisms underlying fear …
Investigating The Functional Connectivity Of The Bed Nucleus Of The Stria Terminalis During Conditions Of Threat And Safety Using High Resolution 7 Tesla Fmri, Walker Scott Pedersen
Investigating The Functional Connectivity Of The Bed Nucleus Of The Stria Terminalis During Conditions Of Threat And Safety Using High Resolution 7 Tesla Fmri, Walker Scott Pedersen
Theses and Dissertations
An influential model of the extended amygdala defines fear as the immediate response to phasic threat and anxiety as the prolonged response to unpredictable or sustained threat (Davis, Walker, Miles & Grillon, 2010). This model proposes that in response to unpredictable threat, the centromedial amygdala (CeA) activates the bed nucleus of the stria terminalis (BNST), which coordinates the anxiety response, and, in turn, inhibits the CeA. Connectivity between the BNST and both the basolateral amygdala (BLA) and hippocampus may also play an important role in the coordination of the anxiety response (Davis et al., 2010; Herman et al., 2003; Zhu, …