Social and Behavioral Sciences Commons^™

Cognitive Remediation Of Working Memory Deficits In Children With Chronic Health Conditions: Tailoring Cogmed Training To Address Barriers To Adherence, Kelsey Smith

Theses and Dissertations

Objective: Children with sickle cell disease (SCD) and cancer are at risk for working memory impairment due to the disease and treatment. However, inconsistency in adherence to cognitive training programs conducted with this population suggests that adaptations are necessary in order to improve the effectiveness of this intervention. In addition, it is unclear whether gains in working memory translate to improvement in classroom functioning.

Methods: Children engaged in cognitive training exclusively over the summer in order to improve adherence to Cogmed Working Memory Training. A total of 17 children ages 7- 17 with a diagnosis of SCD (n = 14) …

Exercise As A Therapeutic For Hiv-1-Associated Neurocognitive Deficits, Michael N. Cranston

Theses and Dissertations

Human Immunodeficiency Virus (HIV-1) afflicts nearly 38 million individuals worldwide (Joseph et al., 2013; “WHO | HIV/AIDS,” 2016). Despite the reduction in disease mortality due to increased use of antiretroviral medication, HIV-1 associated neurocognitive disorder (HAND) affects approximately 50% of HIV infected individuals (Antinori et al., 2007; Castellon, Hinkin, Wood, & Yarema, 1998; Castelo, Sherman, Courtney, Melrose, & Stern, 2006; Cysique & Brew, 2009; Heaton et al., 2011, 2015). The brain itself is particularly sensitive to HIV-1 related viral proteins and viral infection (Masliah, DeTeresa, Mallory, & Hansen, 2000), thus, it is vital to empirically examine potentially effective therapeutics which …