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Social and Behavioral Sciences Commons™
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Full-Text Articles in Social and Behavioral Sciences
A Computational Perspective Of Schizophrenia, Ernesto H. Bedoy, Geoff Powell, Jefferson Kinney
A Computational Perspective Of Schizophrenia, Ernesto H. Bedoy, Geoff Powell, Jefferson Kinney
McNair Poster Presentations
The etiology of schizophrenia remains largely elusive, thus dampening the effectiveness of current treatment strategies. Abnormal neural migration and neurogenesis in the hippocampus have been suggested to be involved in schizophrenia (Jakob & Beckmann, 1994). A few approaches, including computational modeling, have investigated schizophrenia as a network disorder. Computational modeling uses mathematics to predict the behavior of biological systems based on the input of a set of parameters collected from laboratory experiments. In this study, we constructed a computational model to explore the ramifications of additional PV neurons migrating to an aberrant location in the hippocampus and interfering with a …
Ketamine Induced Deficits In Working Memory With Relevance To Schizophrenia, Michael A. Langhardt, Jefferson Kinney
Ketamine Induced Deficits In Working Memory With Relevance To Schizophrenia, Michael A. Langhardt, Jefferson Kinney
McNair Poster Presentations
Schizophrenia is a chronic debilitating brain disorder, which affects approximately one percent of the adult population worldwide. The symptoms of schizophrenia are commonly divided into three broad classes: positive symptoms, negative symptoms, and cognitive disturbances (Kay, et al., 1987). The positive symptoms of schizophrenia include hallucinations, delusions, and disorganized thinking, while the negative symptoms include affective flattening, social withdrawal, and an inability to plan and carry out future activities. The cognitive disturbances exhibited in schizophrenia include deficits in spatial reference and working memory as well as difficulties with focus and attention (Lewis et. al., 2007). Several models have been proposed …