Social and Behavioral Sciences Commons^™

Continuous Theta Rhythm During Spatial Working Memory Task In Rodent Models Of Streptozotocin-Induced Type 2 Diabetes, Stephanie Hernandez, Ryan A. Wirt, James M. Hyman

McNair Poster Presentations

Alzheimer’s disease is a neurodegenerative disorder altering memory loss thought to be due to neuropathological symptoms such as the buildup of beta amyloid plaques (Ab) and neurofibrillary tangles (NFT). The etiology of Alzheimer’s is still unknown; however, potential risk factors such as diabetes may lead to its development. The most common form of diabetes is type 2 diabetes known for persistent insulin resistance leading to a state of hyperglycemia. Insulin resistance has been shown to affect cognitive abilities such as learning, memory and also alters synaptic plasticity. Neural connections between the hippocampus (HC) and anterior cingulate cortex (ACC) are known …