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University of Nebraska - Lincoln
Department of Psychology: Faculty Publications
Nicotine; drug discrimination; conditional stimulus; nicotinic acetylcholine receptor
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Full-Text Articles in Social and Behavioral Sciences
Neuropharmacology Of The Interoceptive Stimulus Properties Of Nicotine, Thomas E. Wooters, Rick A. Bevins, Michael T. Bardo
Neuropharmacology Of The Interoceptive Stimulus Properties Of Nicotine, Thomas E. Wooters, Rick A. Bevins, Michael T. Bardo
Department of Psychology: Faculty Publications
Preclinical drug discrimination techniques play a significant role in advancing our knowledge of the receptor mechanisms underlying the interoceptive effects of nicotine. Early reports confirmed that nicotinic acetylcholine receptors (nAChRs) are critical for transduction of the nicotine cue. In recent years, advances in molecular biology and the discovery of novel ligands with greater selectively for specific nAChR subtypes have furthered our understanding of these mechanisms. There is now evidence regarding the specific nAChR subtypes involved in nicotine discrimination; in addition, there is also evidence suggesting that other systems (i.e., adenosine, cannabinoid, dopamine, glutamate and serotonin) may play a modulatory role. …