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The Effects Of Lobeline On Methamphetamine-Induced Conditioned Place Preference And Dopaminergic Alterations In The Nucleus Accumbens Shell, Nichole Marie Neugebauer

University of Kentucky Doctoral Dissertations

Previous research has suggested that lobeline, a plant alkaloid derived from Lobelia inflate, has potential to be an efficacious pharmacotherapy for the treatment of methamphetamine dependence. In addition to attenuating methamphetamineinduced dopaminergic alterations in vitro, lobeline has been shown to decrease the primary rewarding effects and discriminative stimulus properties of methamphetamine in rats. It is of clinical interest to assess the utility of lobeline to decrease methamphetamine conditioned cues as these cues have been shown to significantly contribute to relapse.

The current studies assessed the ability of lobeline to block the acquisition and expression of methamphetamine-induced conditioned place …