Social and Behavioral Sciences Commons^™

Experiential-Based Feedback During Alcohol Intoxication And Its Effect On Drinkers’ Risk Awareness, Alexandra R. Kelly

Theses and Dissertations--Psychology

The prevalence of alcohol-impaired driving injuries and fatalities has not decreased for over a decade despite strategies to reduce and prevent driving under the influence of alcohol (DUI). In 2019, 10,142 people died in alcohol-impaired driving crashes in the United States, which totaled to 28% of all traffic fatalities for the year. DUI interventions have been found to have moderate effects on reducing DUI recidivism. Prevention research has identified a lack of risk awareness in DUI offenders and this could be a target to motivate behavioral change. However, the training to increase levels of risk awareness needs to occur in …

Blocking The Acquisition Of Ethanol-Induced Conditioned Place Preference With 11, 21-Bisphenyl-19-Norpregnane (Pt150) In Coturnix Quail, Mia Radevski

Theses and Dissertations--Psychology

Alcohol use disorder (AUD) has been associated with a dysregulated stress system. Therefore, regulating stress hormones has been investigated as a potential therapeutic target for AUDs. The purpose of the current study was to investigate whether a stress hormone receptor antagonist, PT150, would block the rewarding properties of ethanol. Quail were used as subjects because a conditioned place preference (CPP) apparatus that utilized visual cues was used, and quail readily attend to visual cues. Visual cues in the environment have been shown to become associated with alcohol effects and later induce craving. Starting on day one, quail were pretreated with …

Pharmacokinetics And Reward-Related Behaviors Of Ethanol In Male And Female Japanese Quail (Coturnix Japonica), Shannon Eaton

Theses and Dissertations--Psychology

Ethanol is one of the most widely used and abused drugs. Problem use is associated with many different health problems and the economic burden is in the billions of dollars. Additionally, many people have difficulty controlling their ethanol consumption and about 5% of adults end up with an alcohol use disorder (AUD). Many people with an AUD often find themselves in a cycle of binge, remission, and relapse.

Following ethanol consumption ethanol enters the bloodstream from the small intestine where it gets distributed to peripheral tissues. Ethanol in the bloodstream is cleared from the system by the liver. The primary …

Influences Among Affect Based Risk Factors And Problem Drinking In College Students, Emily Atkinson

Theses and Dissertations--Psychology

Broad negative affect has been consistently shown to predict problematic alcohol use. More specific affect-based constructs, though, have been shown to predict problem drinking above and beyond broad negative affectivity. The current study aims to investigate transactions among and predictive roles of broad negative affectivity and specific affective-based factors in relation to problem drinking among a sample of 358 students assessed twice during their first year of college. Participants were assessed for negative urgency (the tendency to act rashly when highly emotional), affective lability (the tendency to experience rapid and intense shifts in mood), negative affectivity, and problem drinking via …

Development Of A Translational Model Of Co-Use Of Alcohol And Nicotine For Testing Potential Pharmacotherapies, Sarah Elizabeth Maggio

Theses and Dissertations--Psychology

Co-users of alcohol and nicotine are the largest group of polysubstance users worldwide. Although pharmacotherapies are available for alcohol (EtOH) or tobacco use disorders individually, it may be possible to develop a single pharmacotherapy to treat heavy drinking tobacco smokers through capitalizing on the commonalities in their mechanisms of action. Towards this goal, several models of concurrent access to EtOH and nicotine were explored as potential preclinical models of co-use using female alcohol-preferring (P) rats. Additionally, potential pharmacotherapeutics for the treatment of EtOH and nicotine co-use disorder were tested using different variations of our model. Treatments tested included (1) varenicline, …

Effects Of Multisensory Stop Signals On Sensitivity To Alcohol-Induced Disinhibition In Drinkers With Adhd, Alexandra R. D'Agostino

Theses and Dissertations--Psychology

Multisensory environments facilitate behavioral functioning in humans. The redundant signal effect (RSE) refers to the observation that individuals respond more quickly to stimuli when information is presented as multisensory, redundant stimuli rather than as a single stimulus presented to either modality alone. Our studies show that the disinhibiting effects of alcohol are attenuated when stop signals are multisensory versus unisensory. The present study expanded on this research to test the degree to which multisensory stop signals could also attenuate the disinhibiting effects of alcohol in those with attention-deficit hyperactivity disorder (ADHD), a clinical population characterized by poor impulse control. The …

Characterizing An In Vitro Model Of Severe Focal Traumatic Brain Injury In Hippocampal Slice Cultures: The Effects Of Ethanol And Calpain Inhibition By Mdl-28170, Julia Elaine Jagielo-Miller

Theses and Dissertations--Psychology

In the United States, 2.8 million people suffer a traumatic brain injury (TBI) annually. Between 25%-50% of TBI injuries happen under alcohol intoxication. It is not understood how alcohol impacts patient outcomes via secondary injury pathways. Secondary injury pathways offer a window for therapeutic interventions, but there has been little success finding effective medications. Slice cultures offer a way to study secondary injury mechanisms in a controlled manner. The transection injury can model excitotoxicy seen following TBI. The current studies examined the effect of alcohol intoxication and withdrawal at the time of injury, and the effect of a calpain inhibitor …

Alcohol-Induced Impairment Of Simulated Driving Performance And Behavioral Impulsivity In Dui Offenders, Nicholas A. Van Dyke

Theses and Dissertations--Psychology

Licensed drivers arrested for driving under the influence (DUI) of alcohol have increased rates of vehicle crashes, moving violations, traffic tickets, and contribute to an estimated 120 million occurrences of impaired driving per year (Evans, 2004; Jewett et al., 2015). Survey research on DUI offenders indicates traits of impulsivity (e.g., sensation seeking). Together, these pieces of evidence suggest that DUI offenders display patterns of impulsive action and risk-taking while driving. However, to-date DUI offenders are rarely studied in a laboratory setting, and not much is known about how they respond to a dose of alcohol. The present study examined the …

Cognitive And Behavioral Mechanisms Underlying Alcohol-Induced Risky Driving, Jennifer R. Laude

Theses and Dissertations--Psychology

Alcohol intoxication represents one situation an individual might increase their amount of risk taking when driving. This dissertation is comprised of three studies that investigate the mechanisms by which alcohol increases driver risk-taking. Study 1 examined the effect of alcohol on driver risk-taking using a proxemics approach. The study also tested whether alcohol-induced increases in risky driving co-occurred with pronounced impairment in the driver’s skill. The study also examined whether the most disinhibited drivers were also the riskiest. Indeed, alcohol increased driver risk-taking and impaired driving skill. The study also revealed risky driving can be dissociable from impairing effects on …

The Effects Of Alcohol-Related Visual Stimuli On Inhibitory Control And Attentional Bias: Testing The Roles Of Classical Conditioning And Semantic Priming, Ramey G. Monem

Theses and Dissertations--Psychology

Alcohol research has shown that alcohol-related stimuli can disrupt behavioral control and attract more attention in alcohol drinkers. Stimuli typically used in tasks assessing these mechanisms are likely representative of an individual's history. Responses to visual stimuli that no longer closely resemble an individual's history may help shed light on whether these behaviors are due to classical conditioning or processes such as semantic priming. Hypotheses were tested using typical visual stimuli and modified, abstract versions in these tasks. 41 participants were exposed to these stimuli types while using a visual dot probe task. The difference in degree of attentional bias …

Acute Effects Of Alcohol On Simulated Driving Performance And Self-Perceptions Of Impairment In Dui Offenders, Nicholas A. Van Dyke

Theses and Dissertations--Psychology

Licensed drivers arrested for driving under the influence (DUI) of alcohol have increased rates of vehicle crashes, moving violations, and traffic tickets (Evans, 2004). To date, no research has examined specific self-regulatory mechanisms of the DUI driver under a dose of alcohol that might underlie risky driving behavior. The present study examined the degree to which DUI drivers display an increased sensitivity to the acute impairing effects of alcohol on driving performance and overestimate their driving fitness following alcohol consumption. Adult drivers with a history of DUI and a demographically-matched group of control drivers without a DUI were tested following …

Negative Urgency, Pubertal Onset And The Longitudinal Prediction Of Alcohol Consumption During The Transition From Preadolescence To Adolescence, Lauren Helena Boyle

Theses and Dissertations--Psychology

Alcohol use in early adolescence is associated with numerous concurrent and future problems, including diagnosable alcohol use disorders. The trait of negative urgency, the tendency to act rashly when distressed, is an important predictor of alcohol-related dysfunction in youth and adults. The aim of this study was to test a model proposed by Cyders and Smith (2008) specifying a puberty-based developmental increase in negative urgency, which in turn predicts subsequent increases in early adolescent drinking. In a sample of 1,910 youth assessed semi- annually from spring of 5th grade through spring of 8th grade, we found support for this model. …

Examining The Vulnerability Of Inhibitory Control To The Impairing Effects Of Alcohol, Melissa A. Miller

Theses and Dissertations--Psychology

There is growing evidence that acute changes in fundamental mechanisms of impulse control contribute to the transition from social drinking to abusive drinking. One component of impulsivity concerns the ability to inhibit maladaptive behaviors (i.e., inhibitory control). Inhibitory mechanisms are reliably shown to be sensitive to the impairing effects of alcohol, and studies have begun to show that this impairment fails to recover at the same speed as other aspects of behavior. However, the degree to which inhibitory control develops tolerance to alcohol has only been examined under limited conditions. This dissertation consists of three studies examining contexts in which …

Individual Differences In Escalation Of Tobacco Use: Impulsivity And Alcohol Use, Dustin C. Lee

Theses and Dissertations--Psychology

Like adolescents, young adults are at risk of initiating tobacco use and escalating to daily use and tobacco dependence. However, not every young adult who uses cigarettes intermittently becomes tobacco dependent, and the time-course of those who transition to daily use varies widely. Individual differences likely contribute to the variability observed in patterns of tobacco use. This dissertation uses a multi-modal research approach to examine dimensions of impulsivity and alcohol use that are associated with vulnerability for escalation of cigarette smoking, and whether alcohol’s effects on behavioral disinhibition impact cigarette consumption. Study 1 investigated the associations between dimensions of trait …

Attentional Bias And Alcohol Abuse, Jessica Jane Weafer

Theses and Dissertations--Psychology

Selective attention towards alcohol-related cues (i.e., “attentional bias”) is thought to reflect increased incentive motivational value of alcohol and alcohol cues acquired through a history of heavy alcohol use, and as such attentional bias is considered to be a clinically relevant factor contributing to alcohol use disorders. This dissertation consists of two studies that investigated specific mechanisms through which attentional bias might serve to promote alcohol abuse. Study 1 compared magnitude of attentional bias in heavy (n = 20) and light (n = 20) drinkers following placebo and two doses of alcohol (0.45 g/kg and 0.65 g/kg). Heavy drinkers displayed …