Social and Behavioral Sciences Commons^™

Oxytocin Attenuates Yohimbine-Induced Reinstatement Of Alcohol-Seeking In Female Rats Via The Central Amygdala, Samantha M. Wilfur, Elizabeth C. Mcneely, Aliya A. Lackan, Cassie P. Bowers, Kah-Chung Leong

Psychology Faculty Research

Alcohol use disorder is a significant public health concern, further exacerbated by an increased risk of relapse due to stress. In addition, factors such as biological sex may contribute to the progression of addiction, as females are especially susceptible to stress-induced relapse. While there have been many studies surrounding potential pharmacological interventions for male stress-induced ethanol reinstatement, research regarding females is scarce. Recently, the neuropeptide oxytocin has gained interest as a possible pharmacological intervention for relapse. The present study examines how oxytocin affects yohimbine-induced reinstatement of ethanol-seeking in female rats using a self-administration paradigm. Adult female rats were trained to …