Social and Behavioral Sciences Commons^™

Information Recovery In A Study With Surrogate Endpoints, Song Xi Chen, Denis H. Y. Leung, Jing Qin

Research Collection School Of Economics

Recently, there has been a lot of interest in statistical methods for analyzing data with surrogate endpoints. In this article, we consider parameter estimation from a model that relates a variable Y to a set of covariates, X, in the presence of a surrogate, S. We assume that the data are made up of two random samples from the population, a validation set where (Y, X, S) are observed on every subject and a nonvalidation set where only (X, S) are measured. We show how information from the nonvalidation set can be incorporated to improve upon estimation of a parameter …