Open Access. Powered by Scholars. Published by Universities.®
Social and Behavioral Sciences Commons™
Open Access. Powered by Scholars. Published by Universities.®
- File Type
Articles 1 - 5 of 5
Full-Text Articles in Social and Behavioral Sciences
Membrane Phospholipid Composition, Alterations In Neurotransmitter Systems And Schizophrenia, Xu-Feng Huang, Chao Deng, Teresa Du Bois
Membrane Phospholipid Composition, Alterations In Neurotransmitter Systems And Schizophrenia, Xu-Feng Huang, Chao Deng, Teresa Du Bois
Xu-Feng Huang
No abstract provided.
Alterations To Melanocortinergic, Gabaergic And Cannabinoid Neurotransmission Associated With Olanzapine-Induced Weight Gain, Katrina Weston-Green, Xu-Feng Huang, Chao Deng
Alterations To Melanocortinergic, Gabaergic And Cannabinoid Neurotransmission Associated With Olanzapine-Induced Weight Gain, Katrina Weston-Green, Xu-Feng Huang, Chao Deng
Xu-Feng Huang
Background/Aim: Second generation antipsychotics (SGAs) are used to treat schizophrenia but can cause serious metabolic side-effects, such as obesity and diabetes. This study examined the effects of low to high doses of olanzapine on appetite/ metabolic regulatory signals in the hypothalamus and brainstem to elucidate the mechanisms underlying olanzapineinduced obesity. Methodology/Results: Levels of pro-opiomelanocortin (POMC), neuropeptide Y (NPY) and glutamic acid decarboxylase (GAD65, enzyme for GABA synthesis) mRNA expression, and cannabinoid CB1 receptor (CB1R) binding density (using [3H]SR- 141716A) were examined in the arcuate nucleus (Arc) and dorsal vagal complex (DVC) of female Sprague Dawley rats following 0.25, 0.5, 1.0 …
Temporal And Site-Specific Brain Alterations In Cb1 Receptor Binding In High Fat Diet-Induced Obesity In C57bl/6 Mice, Xu-Feng Huang, Timothy South
Temporal And Site-Specific Brain Alterations In Cb1 Receptor Binding In High Fat Diet-Induced Obesity In C57bl/6 Mice, Xu-Feng Huang, Timothy South
Xu-Feng Huang
The cannabinoid CB1 receptor has been implicated in the regulation of appetite and the consumption of palatable foods. This experiment aimed to explore the involvement of the CB1 receptor in the early and late stages of high fat diet-induced obesity in C57BL/6 mice. The C57Bl/6 mice were placed on a high fat (HF) or low fat/high carbohydrate (LF) diet for 3 or 20 weeks. Quantitative autoradiography revealed that binding of [3H] CP-55,940 (CB1 receptor ligand) was elevated following 3 weeks of HF feeding in areas including the medial/ventral anterior olfactory nucleus (22.1%), agranular insular cortex (24.0%) and the hypothalamus (31.5%) …
Rapid Cortico-Limbic Alterations In Ampa Receptor Densities After Administration Of Pcp: Implications For Schizophrenia., Van Nguyen, Kelly Newell, Xu-Feng Huang, Katerina Zavitsanou, P Ballantyne
Rapid Cortico-Limbic Alterations In Ampa Receptor Densities After Administration Of Pcp: Implications For Schizophrenia., Van Nguyen, Kelly Newell, Xu-Feng Huang, Katerina Zavitsanou, P Ballantyne
Xu-Feng Huang
Phencyclidine (PCP), a non-competitive NMDA/glutamate receptor antagonist, is a psychotomimetic drug that produces a syndrome in normal humans that resembles schizophrenia. The present study investigated the mechanisms of PCP actions by examining the density of glutamate and muscarinic receptors in the rat brain 4 h after a single injection of PCP. We used receptor autoradiography and [3H]MK801, [3H]AMPA, [3H]pirenzepine and [3H]AFDX384 to target glutamate NMDA, glutamate AMPA and muscarinic M1 and M2 receptors, respectively. The major outcome from the present study was an overall decrease in levels of the glutamate AMPA receptor density (F = 14.5, d.f. = 1, p …
Alterations Of Muscarinic And Gaba Receptor Binding In The Posterior Cingulate Cortex In Schizophrenia, Kelly Newell, Xu-Feng Huang, Katerina Zavitsanou, Stephen Kum Jew
Alterations Of Muscarinic And Gaba Receptor Binding In The Posterior Cingulate Cortex In Schizophrenia, Kelly Newell, Xu-Feng Huang, Katerina Zavitsanou, Stephen Kum Jew
Xu-Feng Huang
No abstract provided.