Social and Behavioral Sciences Commons^™

Functional Mri Evaluation Of Multiple Neural Networks Underlying Auditory Verbal Hallucinations In Schizophrenia Spectrum Disorders., Robert J. Thoma, Charlotte Chaze, Jeffrey David Lewine, Vince D. Calhoun, Vincent P. Clark, Juan Bustillo, Jon Houck, Judith Ford, Rose Bigelow, Corbin Wilhelmi, Julia M. Stephen, Jessica A. Turner

Psychology Faculty Publications

Functional MRI studies have identified a distributed set of brain activations to be asso­ ciated with auditory verbal hallucinations (AVH). However, very little is known about how activated brain regions may be linked together into AVH-generating networks. Fifteen volunteers with schizophrenia or schizoaffective disorder pressed buttons to indicate onset and offset of AVH during fMRI scanning. When a general linear model was used to compare blood oxygenation level dependence signals during periods in which subjects indicated that they were versus were not experiencing AVH ("AVH-on" versus "AVH-off"), it revealed AVH-related activity in bilateral inferior frontal and superior temporal regions; the …