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Full-Text Articles in Social and Behavioral Sciences
Relationships Among Processing Speed, Attention, And Biochemical Features In Children Identified With Mitochondrial Disease, Jihye S. Chang
Relationships Among Processing Speed, Attention, And Biochemical Features In Children Identified With Mitochondrial Disease, Jihye S. Chang
Psychology Theses
Mitochondrial Diseases (MD) are disorders of function in cellular oxidative phosphorylation caused by diverse nuclear DNA and mtDNA mutations and seen in 1/5,000 births. The purpose of this study was to examine relationships across medical indices, biochemical measures, and neurobehavioral functioning in children with MD. Findings from Western Blot, Native Gels, High Resolution Respirometry, and the Nijmegen diagnostic criteria were assessed in relation to children’s processing speed and attention, based on the prediction that impaired functioning of proteins, complexes, and cellular respiration, that are critical in ATP production, will impact neurodevelopment and related neuropsychological processes in children with MD. Twenty-five …