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Full-Text Articles in Social and Behavioral Sciences
Chronic Drinking During Adolescence Predisposes The Adult Rat For Continued Heavy Drinking: Neurotrophin And Behavioral Adaptation After Long-Term, Continuous Ethanol Exposure, Gina M. Fernandez, William N. Stewart, Lisa M. Savage
Chronic Drinking During Adolescence Predisposes The Adult Rat For Continued Heavy Drinking: Neurotrophin And Behavioral Adaptation After Long-Term, Continuous Ethanol Exposure, Gina M. Fernandez, William N. Stewart, Lisa M. Savage
Psychology Faculty Scholarship
Previous research has found that adolescent ethanol (EtOH) exposure alters drug seeking behaviors, cognition and neuroplasticity. Using male Sprague Dawley rats, differences in spatial working memory, non-spatial discrimination learning and behavioral flexibility were explored as a function of age at the onset (mid-adolescent vs. adult) of chronic EtOH exposure (CET). Concentrations of mature brain-derived neurotrophic factor (mBDNF) and betanerve growth factor (beta-NGF) in the prefrontal cortex and hippocampus were also assessed at different time-points: during CET, following acute abstinence (48-hrs), and after protracted abstinence (6-8 wks). Our results revealed that an adolescent onset of CET leads to increased EtOH consumption …