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Social and Behavioral Sciences Commons

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Full-Text Articles in Social and Behavioral Sciences

The Development Of Signal Transduction Pathways During Epididymal Maturation Is Calcium Dependent, Heath W. Ecroyd, Kelly Asquith, Russell C. Jones, Robert J. Aitken Jan 2004

The Development Of Signal Transduction Pathways During Epididymal Maturation Is Calcium Dependent, Heath W. Ecroyd, Kelly Asquith, Russell C. Jones, Robert J. Aitken

Faculty of Science - Papers (Archive)

Capacitation has been correlated with the activation of a cAMP-PKA-dependent signaling pathway leading to protein tyrosine phosphorylation. The ability to exhibit this response to cAMP matures during epididymal maturation in concert with the ability of the sperrnatozoa to capacitate. In this study, we have addressed the mechanisms by which spermatozoa gain the potential to activate this signaling pathway during epididymal maturation. In a modified Tyrode's medium containing 1.7 mM calcium, caput spermatozoa had significantly higher [Ca2+](i) than caudal cells and could not tyrosine phosphorylate in response to cAMP. However, in calcium-depleted medium both caput and caudal cells could exhibit a …


Path Integration Deficits During Linear Locomotion After Human Medial Temporal Lobectomy, John W. Philbeck, Marlene Behrmann, Lucien Levy, Samuel J. Potolicchio, Anthony J. Caputy Jan 2004

Path Integration Deficits During Linear Locomotion After Human Medial Temporal Lobectomy, John W. Philbeck, Marlene Behrmann, Lucien Levy, Samuel J. Potolicchio, Anthony J. Caputy

Faculty of Social Sciences - Papers (Archive)

Animal navigation studies have implicated structures in and around the hippocampal formation as crucial in performing path integration (a method of determining one's position by monitoring internally generated self-motion signals). Less is known about the role of these structures for human path integration. We tested path integration in patients who had undergone left or right medial temporal lobectomy as therapy for epilepsy. This procedure removed approximately 50% of the anterior portion of the hippocampus, as well as the amygdala and lateral temporal lobe. Participants attempted to walk without vision to a previously viewed target 2-6 m distant. Patients with right, …


The Role Of Trust In The Marketing And R&D Interface During The Npd Process: A General Framework, Elias Kyriazis, Janette K. Rowland Jan 2004

The Role Of Trust In The Marketing And R&D Interface During The Npd Process: A General Framework, Elias Kyriazis, Janette K. Rowland

Faculty of Commerce - Papers (Archive)

A gap exists in our understanding of the role that "trust" plays within organisations that produce new products. Recent organisational research suggests that trust plays a more significant role in modern organisational structures than previously thought. Trust encourages efficient information sharing, it limits defensive behaviours, encourages citizenship behaviours, it leads to co-operation and teamwork, and encourages collaboration. The NPD literature has traditionally focused on "integration methods" which promote information sharing and interaction amongst participants. Trust has been viewed as a "by product" of these approaches. A framework is proposed which highlights the important role that management play in creating an …