Social and Behavioral Sciences Commons^™

The Role Of Haptic Expectations In Reaching To Grasp: From Pantomime To Natural Grasps And Back Again, Robert L. Whitwell, Nathan J. Katz, Melvyn A. Goodale, James T. Enns

Brain and Mind Institute Researchers' Publications

© Copyright © 2020 Whitwell, Katz, Goodale and Enns. When we reach to pick up an object, our actions are effortlessly informed by the object’s spatial information, the position of our limbs, stored knowledge of the object’s material properties, and what we want to do with the object. A substantial body of evidence suggests that grasps are under the control of “automatic, unconscious” sensorimotor modules housed in the “dorsal stream” of the posterior parietal cortex. Visual online feedback has a strong effect on the hand’s in-flight grasp aperture. Previous work of ours exploited this effect to show that grasps are …

Coexistence Of Perseveration And Apathy In The Tdp-43Q331k Knock-In Mouse Model Of Als–Ftd, Eosu Kim, Matthew A. White, Benjamin U. Phillips, Laura Lopez-Cruz, Hyunjeong Kim, Christopher J. Heath, Jong Eun Lee, Lisa M. Saksida, Jemeen Sreedharan, Timothy J. Bussey

Brain and Mind Institute Researchers' Publications

© 2020, The Author(s). Perseveration and apathy are two of the most common behavioural and psychological symptoms of dementia (BPSDs) in amyotrophic lateral sclerosis–frontotemporal dementia (ALS–FTD). Availability of a validated and behaviourally characterised animal model is crucial for translational research into BPSD in the FTD context. We behaviourally evaluated the male TDP-43Q331K mouse, an ALS–FTD model with a human-equivalent mutation (TDP-43Q331K) knocked into the endogenous Tardbp gene. We utilised a panel of behavioural tasks delivered using the rodent touchscreen apparatus, including progressive ratio (PR), extinction and visual discrimination/reversal learning (VDR) assays to examine motivation, response inhibition and cognitive flexibility, respectively. …

Shared Functional Connectivity Between The Dorso-Medial And Dorso-Ventral Streams In Macaques, R. Stefan Greulich, Ramina Adam, Stefan Everling, Hansjörg Scherberger

Brain and Mind Institute Researchers' Publications

© 2020, The Author(s). Manipulation of an object requires us to transport our hand towards the object (reach) and close our digits around that object (grasp). In current models, reach-related information is propagated in the dorso-medial stream from posterior parietal area V6A to medial intraparietal area, dorsal premotor cortex, and primary motor cortex. Grasp-related information is processed in the dorso-ventral stream from the anterior intraparietal area to ventral premotor cortex and the hand area of primary motor cortex. However, recent studies have cast doubt on the validity of this separation in separate processing streams. We investigated in 10 male rhesus …

Neural Responses And Perceptual Sensitivity To Sound Depend On Sound-Level Statistics, Björn Herrmann, Thomas Augereau, Ingrid S. Johnsrude

Brain and Mind Institute Researchers' Publications

© 2020, The Author(s). Sensitivity to sound-level statistics is crucial for optimal perception, but research has focused mostly on neurophysiological recordings, whereas behavioral evidence is sparse. We use electroencephalography (EEG) and behavioral methods to investigate how sound-level statistics affect neural activity and the detection of near-threshold changes in sound amplitude. We presented noise bursts with sound levels drawn from distributions with either a low or a high modal sound level. One participant group listened to the stimulation while EEG was recorded (Experiment I). A second group performed a behavioral amplitude-modulation detection task (Experiment II). Neural activity depended on sound-level statistical …

Modeling An Auditory Stimulated Brain Under Altered States Of Consciousness Using The Generalized Ising Model, Sivayini Kandeepan, Jorge Rudas, Francisco Gomez, Bobby Stojanoski, Sree Ram Valluri, Adrian Mark Owen, Lorina Naci, Emily Sophia Nichols, Andrea Soddu

Brain and Mind Institute Researchers' Publications

Propofol is a short-acting medication that results in decreased levels of consciousness and is used for general anesthesia. Although it is the most commonly used anesthetic in the world, much remains unknown about the mechanisms by which it induces a loss of consciousness. Characterizing anesthesia-induced alterations to brain network activity might provide a powerful framework for understanding the neural mechanisms of unconsciousness. The aim of this work was to model brain activity in healthy brains during various stages of consciousness, as induced by propofol, in the auditory paradigm. We used the generalized Ising model (GIM) to fit the empirical fMRI …

Face Selective Patches In Marmoset Frontal Cortex, David J. Schaeffer, Janahan Selvanayagam, Kevin D. Johnston, Ravi S. Menon, Winrich A. Freiwald, Stefan Everling

Brain and Mind Institute Researchers' Publications

© 2020, The Author(s). In humans and macaque monkeys, socially relevant face processing is accomplished via a distributed functional network that includes specialized patches in frontal cortex. It is unclear whether a similar network exists in New World primates, who diverged ~35 million years from Old World primates. The common marmoset is a New World primate species ideally placed to address this question given their complex social repertoire. Here, we demonstrate the existence of a putative high-level face processing network in marmosets. Like Old World primates, marmosets show differential activation in anterior cingulate and lateral prefrontal cortices while they view …

Brain Metabolite Levels In Sedentary Women And Non-Contact Athletes Differ From Contact Athletes, Amy L. Schranz, Gregory A. Dekaban, Lisa Fischer, Kevin Blackney, Christy Barreira, Timothy J. Doherty, Douglas D. Fraser, Arthur Brown, Jeff Holmes, Ravi S. Menon, Robert Bartha

Brain and Mind Institute Researchers' Publications

White matter tracts are known to be susceptible to injury following concussion. The objective of this study was to determine whether contact play in sport could alter white matter metabolite levels in female varsity athletes independent of changes induced by long-term exercise. Metabolite levels were measured by single voxel proton magnetic resonance spectroscopy (MRS) in the prefrontal white matter at the beginning (In-Season) and end (Off-Season) of season in contact (N = 54, rugby players) and non-contact (N = 23, swimmers and rowers) varsity athletes. Sedentary women (N = 23) were scanned once, at a time equivalent to the Off-Season …

Structure Of Population Activity In Primary Motor Cortex For Single Finger Flexion And Extension, Spencer A. Arbuckle, Jeff Weiler, Eric A. Kirk, Charles L. Rice, Marc Schieber, J. Andrew Pruszynski, Naveed Ejaz, Jörn Diedrichsen

Brain and Mind Institute Researchers' Publications

Copyright © 2020 the authors How is the primary motor cortex (M1) organized to control fine finger movements? We investigated the population activity in M1 for single finger flexion and extension, using 7T functional magnetic resonance imaging (fMRI) in female and male human participants and compared these results to the neural spiking patterns recorded in two male monkeys performing the identical task. fMRI activity patterns were distinct for movements of different fingers, but were quite similar for flexion and extension of the same finger. In contrast, spiking patterns in monkeys were quite distinct for both fingers and directions, which is …

Cortico-Subcortical Functional Connectivity Profiles Of Resting-State Networks In Marmosets And Humans, Yuki Hori, David J. Schaeffer, Atsushi Yoshida, Justine C. Cléry, Lauren K. Hayrynen, Joseph S. Gati, Ravi S. Menon, Stefan Everling

Brain and Mind Institute Researchers' Publications

Copyright © 2020 the authors Understanding the similarity of cortico-subcortical networks topologies between humans and nonhuman primate species is critical to study the origin of network alternations underlying human neurologic and neuropsychiatric diseases. The New World common marmoset (Callithrix jacchus) has become popular as a nonhuman primate model for human brain function. Most marmoset connectomic research, however, has exclusively focused on cortical areas, with connectivity to subcortical networks less extensively explored. Here, we aimed to first isolate patterns of subcortical connectivity with cortical resting-state networks in awake marmosets using resting-state fMRI, then to compare these networks with those in humans …

Characterizing A Novel Mobile Game Battery Assessment: A Comparison Of Performance-Based And Survey-Based Executive Functioning Instruments, Josephine A. Pham

Electronic Thesis and Dissertation Repository

Exploratory characterization of a novel mobile game battery was conducted via a correlational comparison with a standardized assessment of executive functioning. Previous literature has shown that computer-based and survey-based instruments have either very weak correlation or no correlation at all – giving the impression that these instruments may not measure the same constructs of executive functioning. Findings from the current exploratory study demonstrated significant associations but weak correlational strength between tasks from the computer-based game battery and an updated standardized survey-based instrument. This confirmed a trend found in previous literature, demonstrating little overlap between both instruments in executive functioning measurement. …

Conscious Perception And Implicit Memory Formation Of A Narrative Presented During Sleep, Sarah E. Hollywood

Electronic Thesis and Dissertation Repository

The present study sought to determine the extent of conscious awareness and implicit memory formation of a narrative presented during sleep. Participants were played an excerpt of J.D. Salinger’s Pretty Mouth and Green My Eyes while napping. Afterwards, participants completed a task designed to assess implicit memory to determine if they had formed any memories about words that were either directly stated in the story, or directly related to the plot. Participants who heard the story while asleep responded more quickly to words that had appeared in the story than to words from another story they had not heard. Exactly …

Direct Visualization And Characterization Of The Human Zona Incerta And Surrounding Structures, Jonathan C. Lau, Yiming Xiao, Roy A.M. Haast, Greydon Gilmore, Kâmil Uludağ, Keith W. Macdougall, Ravi S. Menon, Andrew G. Parrent, Terry M. Peters, Ali R. Khan

Brain and Mind Institute Researchers' Publications

The zona incerta (ZI) is a small gray matter region of the deep brain first identified in the 19th century, yet direct in vivo visualization and characterization has remained elusive. Noninvasive detection of the ZI and surrounding region could be critical to further our understanding of this widely connected but poorly understood deep brain region and could contribute to the development and optimization of neuromodulatory therapies. We demonstrate that high resolution (submillimetric) longitudinal (T1) relaxometry measurements at high magnetic field strength (7 T) can be used to delineate the ZI from surrounding white matter structures, specifically the fasciculus cerebellothalamicus, fields …

The Neural Basis Of Metacognitive Monitoring During Arithmetic In The Developing Brain, Elien Bellon, Wim Fias, Daniel Ansari, Bert De Smedt

Brain and Mind Institute Researchers' Publications

In contrast to a substantial body of research on the neural basis of cognitive performance in several academic domains, less is known about how the brain generates metacognitive (MC) awareness of such performance. The existing work on the neurobiological underpinnings of metacognition has almost exclusively been done in adults and has largely focused on lower level cognitive processing domains, such as perceptual decision-making. Extending this body of evidence, we investigated MC monitoring by asking children to solve arithmetic problems, an educationally relevant higher-order process, while providing concurrent MC reports during fMRI acquisition. Results are reported on 50 primary school children …

Children’S Perspectives On The Social Exclusion Of Peers With Behavioural Difficulties, Kayla Edwards

Electronic Thesis and Dissertation Repository

Children who display externalizing behaviours are more likely than their peers to experience social exclusion. To better examine this topic, the perspectives of peers were investigated. Thirty-six participants were interviewed from a school in Southwestern Ontario. Participants were asked why they believe children with behavioural difficulties may be socially excluded by peers. Unique statements were extracted from the transcribed data. Participants were invited back to sort the statements into meaningful categories. Sorted data were analyzed using multi-dimensional scaling and cluster analysis. A five-cluster solution was selected as the best conceptual and statistical fit for the data. The clusters in this …

The Psychosocial Functioning Of Children With Chronic Health Conditions: A Meta-Analysis, Serena Thompson

Electronic Thesis and Dissertation Repository

Chronic health conditions are highly prevalent among childhood populations and lead to restrictions in everyday life. Previous research indicates that children and youth with a chronic health condition are at an elevated risk of psychosocial difficulties, including mental illness and social exclusion, compared to typically developing populations. Therefore, the purpose of this study was to determine the impact of chronic health conditions on psychosocial factors during childhood by comparing the psychosocial functioning of children with chronic health conditions and children without chronic illnesses using a meta-analysis. Specifically, three elements of psychosocial functioning were examined, (a) social-emotional functioning, (b) behavioural functioning, …

The Impact Of Levodopa Administration On Learning From Short-Term And Long-Term Action Consequences: A Paradigm Validation., Masood Rezaei

Electronic Thesis and Dissertation Repository

Behavioral and neuroimaging studies have identified two valuation systems in the human brain for controlling behavior known as model-free (MF) and model-based (MB). MF is based on immediate evaluation and MB is based on long-term evaluation of the outcome of our decisions. Previous studies suggest that dopamine baseline activity may play an important role in the balance between the two systems and determine how they compete or interact in controlling our actions. The overarching aims of this study is to investigate the impact of levodopa administration on learning from immediate and long-term action consequences, and to dissociate the role of …

Who Are We Missing? The Impact Of Requiring Parental Or Guardian Consent On Research With Lesbian, Gay, Bisexual, Trans, Two-Spirit, Queer/Questioning Youth., Eli Cwinn, Courtney Cadieux, Claire V Crooks

Education Publications

PURPOSE: The purpose was to examine whether a requirement for parental or guardian consent systematically limits which lesbian, gay, bisexual, trans, two-spirit, queer/questioning (LGBT2Q+) youth participate in research.

METHODS: A total of 60 LGBT2Q+ youth (aged 14-18 years) completed measures assessing gender and sexual minority identity, depression and anxiety, help-seeking intentions, and social support.

RESULTS: A substantial proportion (37.6%) of youth reported that they would not have participated in the research if parental or guardian consent was required. Those who would not have participated had more negative attitudes about their sexual and gender identity, less family support, lower levels of …

Toward A Fluid Cinematic Spectatorship And Desire: Revisiting Laura Mulvey’S Psychoanalytic Film Theories, Taylor Ashton Mcgoey

Electronic Thesis and Dissertation Repository

This thesis project re-evaluates Laura Mulvey’s film theories regarding psychoanalysis and the “male gaze,” first found in her essay “Visual Pleasure and Narrative Cinema” (1975). By re-evaluating the limitations of Mulvey’s use of the Freudian and Lacanian psychoanalytic model this project seeks to understand the desires and processes of identification of cinematic spectators who reject the ideological imperative of the “male gaze”. As many critics have noted, Mulvey’s initial examination of cinema does not account for LGBTQ+ spectators and/or black spectators who occupy looking relations that reject cis-normative and heteronormative white Hollywood cinematic conventions. From this standpoint, we begin the …

Autistic Traits And Cognitive Biases For Emotional Faces In Neurotypicals, Meara Stow

Electronic Thesis and Dissertation Repository

Cognitive biases can involve the tendency to extract some sensory inputs while ignoring others. Cognitive biases impact perception, and subsequent processing decisions made on the basis of perception. Cognitive biases can disrupt accurate and efficient processing of social information, and may underlie core features of social communication difficulties. How cognitive biases contribute to atypical social processing associated with autism spectrum disorder (ASD) traits is unknown. We examined whether cognitive biases for emotional faces were related to scores from the Autism-Spectrum Quotient (AQ), and whether our measures of cognitive biases from a dot- probe paradigm with concurrent eye tracking were comparable. …

Moving Beyond The Mat: Exploring The Application Of Mindfulness Training In Professional And Educational Settings, Emily G. Nielsen

Electronic Thesis and Dissertation Repository

Objectives. This dissertation provides an evaluation of three web-based mindfulness interventions administered to legal professionals and graduate students — populations characterized by high rates of depression, anxiety, and stress. Chapter 2, Study 1. Lawyers completed questionnaires before and after engaging in Cho and Gifford’s (2016) 8-week Anxious Lawyer program. Analyses revealed improvements in perceived stress; mood; resilience; trait mindfulness; and the severity of depression, anxiety, and stress-related symptoms over time. Chapter 2, Study 2. Lawyers were randomly assigned to either an experimental or waitlist control condition. Well-being was measured at the beginning of the study (i.e., Time 1), after experimental …

Understanding Differences In Social Learning, Joshua Patenaude

Electronic Thesis and Dissertation Repository

Previous research has shown that individuals with autism spectrum disorder (ASD) appear to learn from social and non-social rewards at different rates compared to typically developing individuals. Several hypotheses have been developed to explain these differences, including the social motivation hypothesis, the weak central coherence hypothesis and hypotheses related to probabilistic learning ability. However, in all cases, the literature shows only mixed support for these ideas. This dissertation focuses on identifying which assumptions from these hypotheses replicate and what replication successes and failures mean for the study of autism-spectrum traits within the general population.

This work takes a “spectrum” approach …

Syllables In Sync Form A Link: Neural Phase-Locking Reflects Word Knowledge During Language Learning, Laura Batterink

Brain and Mind Institute Researchers' Publications

Language is composed of small building blocks, which combine to form larger meaningful structures. To understand language, we must process, track, and concatenate these building blocks into larger linguistic units as speech unfolds over time. An influential idea is that phase-locking of neural oscillations across different levels of linguistic structure provides a mechanism for this process. Building on this framework, the goal of the current study was to determine whether neural phase-locking occurs more robustly to novel linguistic items that are successfully learned and encoded into memory, compared to items that are not learned. Participants listened to a continuous speech …

Decoding Motor Imagery And Action Planning In The Early Visual Cortex: Overlapping But Distinct Neural Mechanisms, Simona Monaco, Giulia Malfatti, Jody C. Culham, Luigi Cattaneo, Luca Turella

Brain and Mind Institute Researchers' Publications

Recent evidence points to a role of the primary visual cortex that goes beyond visual processing into high-level cognitive and motor-related functions, including action planning, even in absence of feedforward visual information. It has been proposed that, at the neural level, motor imagery is a simulation based on motor representations, and neuroimaging studies have shown overlapping and shared activity patterns for motor imagery and action execution in frontal and parietal cortices. Yet, the role of the early visual cortex in motor imagery remains unclear. Here we used multivoxel pattern analyses on functional magnetic resonance imaging (fMRI) data to examine whether …

Pain In The Newborn Brain: A Neural Signature, Emma G. Duerden, Steven P. Miller

Brain and Mind Institute Researchers' Publications

No abstract provided.

An Auditory-Perceptual And Pupillometric Study Of Vocal Strain And Listening Effort In Adductor Spasmodic Dysphonia, Mojgan Farahani, Vijay Parsa, Björn Herrmann, Mason Kadem, Ingrid Johnsrude, Philip C. Doyle

Brain and Mind Institute Researchers' Publications

© 2020 by the authors. This study evaluated ratings of vocal strain and perceived listening effort by normal hearing participants while listening to speech samples produced by talkers with adductor spasmodic dysphonia (AdSD). In addition, objective listening effort was measured through concurrent pupillometry to determine whether listening to disordered voices changed arousal as a result of emotional state or cognitive load. Recordings of the second sentence of the "Rainbow Passage" produced by talkers with varying degrees of AdSD served as speech stimuli. Twenty naïve young adult listeners perceptually evaluated these stimuli on the dimensions of vocal strain and listening effort …

Homotopic Coupling In Persons With Epilepsy Using Movie-Driven And Resting-State Fmri, Caroline M. Chadwick

Electronic Thesis and Dissertation Repository

For the 30-40% of persons with epilepsy (PWE) with refractory epilepsy, seizure freedom following surgery is affected by the localization of the epileptogenic zone (EZ). However, functional abnormalities can exist at a distance from the EZ, which may contribute to variable outcomes after surgery. Considering epilepsy as a network disorder (Pittau & Vulliemoz, 2015), and evaluating functional coupling among homotopic brain areas, may help predict cognitive outcomes. Homotopic areas are well connected anatomically and undoubtedly work synchronously to generate cognition. We evaluated 22 persons with focal epilepsy and 24 neurologically healthy controls using fMRI at rest and while watching a …

Linguistic Signaling In Speed-Dates, Negar Mohammad Vali Samani

Electronic Thesis and Dissertation Repository

How people use language may signal as much about a person as the conversation topic itself. For example, evidence suggests that similarities in language style may signal romantic interest as people become acquainted. Additionally, language may signal various personal attributes. In the current study, I analyzed linguistic signaling in 174 transcripts from 4-minute heterosexual speed-dates to explore how language style relates to interest in dating a partner and whether linguistic features indicate individual characteristics. I also explored how desired partner features related to actual popularity of dates as well as how partner perceptions predicted romantic interest. Contrary to previous research, …

Rapid Facial Reactions Of Emotional Expressions As A Function Of Trait Sadism, Cathleen Fleury

Electronic Thesis and Dissertation Repository

Using electromyography (EMG), it has been shown that facial muscles imperceptibly mirror the facial expressions of others, a phenomenon referred to as rapid facial reactions (RFRs). It was previously believed to follow the direct-matching hypothesis, however several recent studies have demonstrated that context and individual differences may be influencing factors on RFRs. At the present, it is unclear to what extent RFRs can be modulated. In the present study, we propose to determine the effects of facial stimuli versus non-facial stimuli on RFRs through measuring the EMG response of participants with trait sadism. The participants observed dynamic facial expressions as …

An Ontological Critique Of The Self: The Daoist ‘Non-Self’ At The Heart Of Jung’S Analytical Theory, Camilo Andrés Hoyos Lozano

Electronic Thesis and Dissertation Repository

This research attempts to formulate a critique of the Jungian self from the Daoist, Lao-Zhuang notion of non-self. In post-modern societies an ontological critique of the self is also ideological, for the self is an indispensable device of neoliberal government. Because for Jung the self is an essential and autonomous reality, he advances a dualism that not only legitimizes the current economic and political order, but—focal to this analysis—also complicates the ‘realization’ of the ultimate spiritual ‘goal,’ and his own purpose of treating psychological suffering. Thus, the critical power and political potential of the Daoist non-self serves to demystify analytical …

Feeling-Of-Knowing Experiences Breed Curiosity, Gregory Brooks

Electronic Thesis and Dissertation Repository

It is well-established that curiosity has benefits for learning. Less is known about potential links between curiosity and memory retrieval. In theoretical work on metacognition it has been argued that retrieval experiences that occur during memory search can exert control over behaviour. States of curiosity, which can be defined as behavioural tendencies to seek out information, may play a critical role in this control function. We conducted two experiments to address this idea, focusing on links between feeling-of knowing (FOK) experiences, memory-search duration, and subsequent information-seeking behaviour. We administered an episodic FOK paradigm that probed memory for previously studied arbitrary …