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Full-Text Articles in Social and Behavioral Sciences
Higher Order C(T, P, S) Crossover Designs, James F. Reed Iii
Higher Order C(T, P, S) Crossover Designs, James F. Reed Iii
Journal of Modern Applied Statistical Methods
A crossover study is a repeated measures design in which each subject is randomly assigned to a sequence of treatments, including at least two treatments. The most damning characteristic of a crossover study is the potential of a carryover effect of one treatment to the next period. To solve the first-order crossover problem characteristic in the classic AB|BA design, the design must be extended. One alternative uses additional treatment sequences in two periods; a second option is to add a third period and repeat one of the treatments. Assuming a traditional model that specifies a first-order carryover effect, this study …
Extension Of Grizzle’S Classic Crossover Design, James F. Reed Iii
Extension Of Grizzle’S Classic Crossover Design, James F. Reed Iii
Journal of Modern Applied Statistical Methods
The crossover design compares treatments A and B over two periods using sequences AB and BA (the AB|BA design) and is the classic design most often illustrated and critiqued in textbooks. Other crossover designs have been used but their use is relatively rare and not always well understood. This article introduces alternatives to a randomized two-treatment, two-period crossover study design. One strategy, which is to extend the classic AB|BA by adding a third period to repeat one of the two treatments, has several attractive advantages; an added treatment period may not imply a large additional cost but will allow carryover …