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Social and Behavioral Sciences Commons™
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Articles 1 - 30 of 341
Full-Text Articles in Social and Behavioral Sciences
Partner Influence In Diet And Exercise Behaviors: Testing Behavior Modeling, Social Control, And Normative Body Size, Brea Perry, Gabriele Ciciurkaite, Christy Freadreacea Brady, Justin Garcia
Partner Influence In Diet And Exercise Behaviors: Testing Behavior Modeling, Social Control, And Normative Body Size, Brea Perry, Gabriele Ciciurkaite, Christy Freadreacea Brady, Justin Garcia
Sociology Faculty Publications
Previous research has documented social contagion in obesity and related health behaviors, but less is known about the social processes underlying these patterns. Focusing on married or cohabitating couples, we simultaneously explore three potential social mechanisms influencing obesity: normative body size, social control, and behavior modeling. We analyze the association between partner characteristics and the obesity-related health behaviors of focal respondents, comparing the effects of partners’ body type, partners’ attempts to manage respondents’ eating behaviors, and partners’ own health behaviors on respondents’ health behaviors (physical activity, fruit and vegetable consumption, and fast food consumption). Data on 215 partners are extracted …
Regular Expressions In Practice, Kathryn Lybarger
Regular Expressions In Practice, Kathryn Lybarger
Library Presentations
Regular expressions are not just for programmers anymore; they are supported by common software and systems used for cataloging and metadata, and allow for very powerful search and replace, even complete reformatting of library data! In this webinar, we’ll discuss the building blocks of regular expressions, practice identifying what they match (and do not match!), and consider how we can use them to make everyday library work more efficient.
Alcohol Use And Strenuous Physical Activity In College Students: A Longitudinal Test Of 2 Explanatory Models Of Health Behavior, Heather A. Davis, Elizabeth N. Riley, Gregory T. Smith, Richard S. Milich, Jessica L. Burris
Alcohol Use And Strenuous Physical Activity In College Students: A Longitudinal Test Of 2 Explanatory Models Of Health Behavior, Heather A. Davis, Elizabeth N. Riley, Gregory T. Smith, Richard S. Milich, Jessica L. Burris
Psychology Faculty Publications
Objective: To help clarify the effect of gender on the bidirectional relationship between alcohol use and strenuous physical activity in college students. Participants: Five hundred twenty-four (52% female) college students recruited in August 2008 and 2009 and followed up in April 2009 and April 2011, respectively. Methods: Participants reported their alcohol use and strenuous physical activity on 2 occasions (baseline and follow-up) spaced approximately 1 or 2 years apart. Results: For females, alcohol use quantity at baseline was associated with increased strenuous physical activity at 1- and 2-year follow-ups, and alcohol use frequency at baseline was …
The Carrot And The Stick? Strategies To Improve Compliance With College Campus Tobacco Policies, Amanda Fallin-Bennett, Maria Roditis, Stanton A. Glantz
The Carrot And The Stick? Strategies To Improve Compliance With College Campus Tobacco Policies, Amanda Fallin-Bennett, Maria Roditis, Stanton A. Glantz
Nursing Faculty Publications
Objective: Tobacco-free policies are being rapidly adopted nationwide, yet compliance with these policies remains a challenge. This study explored college campus key informants' experiences with tobacco policies, and their perceived benefits, drawbacks, and outcomes. Participants: The sample for this study was 68 key informants representing 16 different California universities with varying tobacco policies (no smoking indoors and within 20 feet of entrances, designated smoking areas, 100% smoke-free, and 100% tobacco-free). Methods: Qualitative, descriptive study. Semistructured interviews were transcribed verbatim and analyzed using content analysis. Results: Strategies to improve compliance ranged from a social approach to a …
Selective Suppression Of The Α Isoform Of P38 Mapk Rescues Late-Stage Tau Pathology, Nicole Maphis, Shanya Jiang, Guixiang Xu, Olga N. Kokiko-Cochran, Saktimayee M. Roy, Linda J. Van Eldik, D. Martin Watterson, Bruce T. Lamb, Kiran Bhaskar
Selective Suppression Of The Α Isoform Of P38 Mapk Rescues Late-Stage Tau Pathology, Nicole Maphis, Shanya Jiang, Guixiang Xu, Olga N. Kokiko-Cochran, Saktimayee M. Roy, Linda J. Van Eldik, D. Martin Watterson, Bruce T. Lamb, Kiran Bhaskar
Sanders-Brown Center on Aging Faculty Publications
Background: Hyperphosphorylation and aggregation of tau protein are the pathological hallmarks of Alzheimer’s disease and related tauopathies. We previously demonstrated that the microglial activation induces tau hyperphosphorylation and cognitive impairment via activation of p38 mitogen-activated protein kinase (p38 MAPK) in the hTau mouse model of tauopathy that was deficient for microglial fractalkine receptor CX3CR1.
Method: We report an isoform-selective, brain-permeable, and orally bioavailable small molecule inhibitor of p38α MAPK (MW181) and its effects on tau phosphorylation in vitro and in hTau mice.
Results: First, pretreatment of mouse primary cortical neurons with MW181 completely blocked inflammation-induced p38α MAPK activation and AT8 …
Dna Methylation Signatures Of Chronic Low-Grade Inflammation Are Associated With Complex Diseases, Symen Ligthart, Carola Marzi, Stella Aslibekyan, Michael M. Mendelson, Karen N. Conneely, Toshiko Tanaka, Elena Colicino, Lindsay L. Waite, Roby Joehanes, Weihua Guan, Jennifer A. Brody, Cathy Elks, Riccardo Marioni, Min A. Jhun, Golareh Agha, Jan Bressler, Cavin K. Ward-Caviness, Brian H. Chen, Tianxiao Huan, Kelly Bakulski, Elias L. Salfati, Whi-Empc Investigators, Giovanni Fiorito, Charge Epigenetics Of Coronary Heart Disease, Simone Wahl, Katharina Schramm, Jin Sha, Dena G. Hernandez, Allan C. Just, Jennifer A. Smith, Donna K. Arnett
Dna Methylation Signatures Of Chronic Low-Grade Inflammation Are Associated With Complex Diseases, Symen Ligthart, Carola Marzi, Stella Aslibekyan, Michael M. Mendelson, Karen N. Conneely, Toshiko Tanaka, Elena Colicino, Lindsay L. Waite, Roby Joehanes, Weihua Guan, Jennifer A. Brody, Cathy Elks, Riccardo Marioni, Min A. Jhun, Golareh Agha, Jan Bressler, Cavin K. Ward-Caviness, Brian H. Chen, Tianxiao Huan, Kelly Bakulski, Elias L. Salfati, Whi-Empc Investigators, Giovanni Fiorito, Charge Epigenetics Of Coronary Heart Disease, Simone Wahl, Katharina Schramm, Jin Sha, Dena G. Hernandez, Allan C. Just, Jennifer A. Smith, Donna K. Arnett
Epidemiology and Environmental Health Faculty Publications
Background: Chronic low-grade inflammation reflects a subclinical immune response implicated in the pathogenesis of complex diseases. Identifying genetic loci where DNA methylation is associated with chronic low-grade inflammation may reveal novel pathways or therapeutic targets for inflammation.
Results: We performed a meta-analysis of epigenome-wide association studies (EWAS) of serum C-reactive protein (CRP), which is a sensitive marker of low-grade inflammation, in a large European population (n = 8863) and trans-ethnic replication in African Americans (n = 4111). We found differential methylation at 218 CpG sites to be associated with CRP (P < 1.15 × 10–7) in the discovery panel …
Do You Have A Stapler?: Evenings At The Reference Desk, Katie Smith, Lauren Farmer
Do You Have A Stapler?: Evenings At The Reference Desk, Katie Smith, Lauren Farmer
LIS Student Conference
No abstract provided.
Community Resource Audit Of Low-Income And Poor Children, Jesse Caldwell
Community Resource Audit Of Low-Income And Poor Children, Jesse Caldwell
LIS Student Conference
Poverty is on the rise within the United States. Public Libraries located in large cities and rural communities may be seeing an increase in usage from children who identify as low-income or poor. Using national statistics from the United States and local statistics from Lawrenceburg, Indiana , I will explain how poverty is on the rise within the United States. I will then outline how to discover local poverty statistics and how those statistics can be used to directly engage the low-income and poor population within a library district.
Physicians’ Information Needs And Information Seeking, William E. Burchfield Ii
Physicians’ Information Needs And Information Seeking, William E. Burchfield Ii
LIS Student Conference
Physicians range in age from their early twenties to their nineties. These same physicians care for people many times, from before their birth until their end of life experiences. Physicians must provide the best possible care to these patients. In order to do this, physicians need information. This poster presentation explores the information needs of physicians as well as the information seeking behavior these physicians follow.
The Invisible: Serving Individuals With Autism Spectrum Disorder, A Sensitivity Training, Rachel Combs
The Invisible: Serving Individuals With Autism Spectrum Disorder, A Sensitivity Training, Rachel Combs
LIS Student Conference
According to the CDC, autism is the fastest-growing developmental disability (2008). In the US, the prevalence is estimated at 1 in 68 births. Academic libraries need to be aware of this growing population so that we can educate library staff and be prepared to help people who learn and communicate differently. College students with disabilities face inequity when using the academic library, including the physical space, the library website, programming or lack thereof, restrictive loan periods, and resources that aren’t available in formats that they need. Academic libraries must be proactive and learn to recognize and minimize barriers, educate library …
Community Resource Audit: Teen Users, Ashley Householder
Community Resource Audit: Teen Users, Ashley Householder
LIS Student Conference
This poster presents the findings from my Community Resource Audit in LIS 601, which focused on teen library users. During my research, I found that teens usually seek information on the following topics: Health, Career Information, Homework Help, Reading Material, News, and General Curiosity. Along with addressing these needs, my presentation will also discuss barriers to teen access, including reasons why they might choose not to seek information. Finally, I will present my "Teen Resource Guide," which was designed to help teens conduct research on each of the aforementioned topics.
Practicum In A Medical Library, Emily Elkind
Practicum In A Medical Library, Emily Elkind
LIS Student Conference
Sharing my work that I have done during my practicum in the St. Joseph Hospital Medical library, including lists of both print and digital resources, and a potential list of helpful resources for the tentative consumer health resources center.
The Special Collections Research Center's Education Program: A Reflection On Success, Natalie Bishop
The Special Collections Research Center's Education Program: A Reflection On Success, Natalie Bishop
LIS Student Conference
The Special Collections Research Center's education program offers students across all departments and disciplines the opportunity to learn from primary sources. By demystifying the research process, students are provided with powerful learning opportunities. As the Education Archivist Graduate Assistant, I plan and create activities for students visiting the SCRC to facilitate student learning and improve information literacy. This fast-growing, innovative program reached 2,038 students during the 2015-2016 academic year, and this is only one of many pieces of evidence pointing to the program's success.
The Teen Toolkit: Providing Reliable Resources To Students, Jaclyn Spraetz
The Teen Toolkit: Providing Reliable Resources To Students, Jaclyn Spraetz
LIS Student Conference
This poster highlights the Community Resource Audit I created on teenagers’ information seeking behaviors. By conducting a literature review as well as distributing a survey to teens, I found that while they want to be informed, they often do not seek out many different types of informational resources. To respond, I created an online guide that presents reliable open resources to help students with class projects and additional outlets to help them stay informed on current events.
Diabetes Patients: Information Needs And Seeking Behaviors, Lauren Colburn
Diabetes Patients: Information Needs And Seeking Behaviors, Lauren Colburn
LIS Student Conference
Diabetes is currently the seventh leading cause of death in America. Currently, 9.3% of the American population has diabetes, and self-management is a crucial step in managing the disease well. Therefore, this community resource audit focuses on the information needs and seeking behaviors of these patients as they navigate life with diabetes.
Library School: On How And Why, And Especially With Whom, One Becomes A Librarian, Karyn Hinkle
Library School: On How And Why, And Especially With Whom, One Becomes A Librarian, Karyn Hinkle
LIS Student Conference
No abstract provided.
Individual Differences In Intentional And Unintentional Exposure To Online Pornography Among Hong Kong Chinese Adolescents, Cecilia M. S. Ma, Daniel T. L. Shek, Catie C. W. Lai
Individual Differences In Intentional And Unintentional Exposure To Online Pornography Among Hong Kong Chinese Adolescents, Cecilia M. S. Ma, Daniel T. L. Shek, Catie C. W. Lai
Pediatrics Faculty Publications
The current study aimed to test how gender and religion affect unintentional and intentional exposure to online pornography in Chinese adolescents. A total of 1401 secondary school students (age range from 11 to 16 years) participated in the study. Findings from multivariate analyses show that males reported higher levels of unintentional and intentional exposure to online pornography than females. Significant differences were found in adolescents’ religiosity, with students who had religious beliefs reporting a lower level of unintentional exposure to online pornography than their counterparts without religious beliefs. In terms of intentional exposure to online pornography, adolescents were more likely …
Perceived Effectiveness And Satisfaction Of A Community-Based Positive Youth Development Program: Findings Based On High School Students, Daniel T. L. Shek, Janet T. Y. Leung, Moon Y. M. Law, Kles S. Y. Chan
Perceived Effectiveness And Satisfaction Of A Community-Based Positive Youth Development Program: Findings Based On High School Students, Daniel T. L. Shek, Janet T. Y. Leung, Moon Y. M. Law, Kles S. Y. Chan
Pediatrics Faculty Publications
This study examined participants’ perceptions of a community-based positive youth development (PYD) program (the Project P.A.T.H.S.) based on the responses of 16,420 junior secondary students who joined the program in 2015. Subjective outcome evaluation approach was adopted to examine the students’ views of program content, program instructors, and program effectiveness. Consistent with previous studies, results showed that students generally perceived the program positively, and positive relationships were found amongst the three domains of evaluation. Multiple regression analyses showed that perceived program content and instructor qualities were significant predictors and could explain 35% of the variance in program effectiveness perceived by …
Prevalence Of Triple-Negative Breast Cancer In India: Systematic Review And Meta-Analysis, Gurprataap S. Sandhu, Sebhat Erqou, Heidi Patterson, Aju Mathew
Prevalence Of Triple-Negative Breast Cancer In India: Systematic Review And Meta-Analysis, Gurprataap S. Sandhu, Sebhat Erqou, Heidi Patterson, Aju Mathew
Markey Cancer Center Faculty Publications
Purpose There is considerable variation in prevalence rates of triple-negative breast cancer (TNBC) reported by various studies from India. We performed a systematic review and literature-based meta-analysis of these studies.
Methods We searched databases of Medline, Scopus, EMBASE, and Web of Science for studies that reported on the prevalence of TNBC in India that were published between January 1, 1999, and December 31, 2015. We extracted relevant information from each study by using a standardized form. We pooled study-specific estimates by using random-effects meta-analysis to provide summary estimates. We explored sources of heterogeneity by using subgroup analyses and metaregression.
Results …
Development, Validation And Application Of A New Fornix Template For Studies Of Aging And Preclinical Alzheimer's Disease, Christopher A. Brown, Nathan F. Johnson, Amelia J. Anderson-Mooney, Gregory A. Jicha, Leslie M. Shaw, John Q. Trojanowski, Linda J. Van Eldik, Frederick A. Schmitt, Charles D. Smith, Brian T. Gold
Development, Validation And Application Of A New Fornix Template For Studies Of Aging And Preclinical Alzheimer's Disease, Christopher A. Brown, Nathan F. Johnson, Amelia J. Anderson-Mooney, Gregory A. Jicha, Leslie M. Shaw, John Q. Trojanowski, Linda J. Van Eldik, Frederick A. Schmitt, Charles D. Smith, Brian T. Gold
Physical Therapy Faculty Publications
We developed a merged younger-older adult template of the fornix and demonstrated its utility for studies of aging and preclinical Alzheimer's disease (AD). In Experiment 1, probabilistic tractography was used to reconstruct the fornix in younger and older adults and successful streamlines were then averaged to create a merged template in standard space. The new template includes the majority of the fornix from the hippocampal formation to the subcallosal region and the thalamus/hypothalamus. In Experiment 2, the merged template was validated as an appropriate measure for studies of aging, with comparisons against manual tracing measures indicating identical spatial coverage in …
Individual And Family Protective Factors Of Intentional And Unintentional Consumption Of Online Pornography In Hong Kong, Cecilia M. S. Ma, Daniel T. L. Shek, Catie C. W. Lai
Individual And Family Protective Factors Of Intentional And Unintentional Consumption Of Online Pornography In Hong Kong, Cecilia M. S. Ma, Daniel T. L. Shek, Catie C. W. Lai
Pediatrics Faculty Publications
The purpose of the current study was to explore how positive youth development and family functioning were related to unintentional and intentional exposure to online pornography in Chinese adolescents. A total of 1401 secondary school students (mean age=12.43) participated in the study. Findings suggested that positive youth development and family functioning were associated with lower exposure to online pornography. In particular, higher levels of spirituality, social competence, mutuality and communication were associated with lower levels of both types of exposure to online pornography. Discussion focuses on the importance of promoting positive youth development and family functioning as protective factors against …
Psychological Needs, Self-Regulation, And Motivation Profiles Among A Sample Of Hong Kong Chinese University Students: A Person-Centered Approach, Cecilia M. S. Ma, Daniel T. L. Shek, Catie C. W. Lai
Psychological Needs, Self-Regulation, And Motivation Profiles Among A Sample Of Hong Kong Chinese University Students: A Person-Centered Approach, Cecilia M. S. Ma, Daniel T. L. Shek, Catie C. W. Lai
Pediatrics Faculty Publications
To better understand factors that influence individuals’ motivation to engage in physical activity, this study aimed to identify the motivational profiles among the Chinese university students, compare the motivational profiles between genders, and explore whether satisfaction of various psychological needs vary with different motivational profiles. Two thousand and twenty-two Chinese university students completed a battery of self-report questionnaires assessing motivation regulation and psychological needs satisfaction. Three motivational profiles were identified for both genders. The overall patterns of the motivational profiles for both genders were similar. However, males (44%) were more likely than their female counterparts (19%) in self-determined profile group. …
Qualitative Evaluation Of A Service Leadership Subject In A Chinese Context, Daniel T. L. Shek, Jing Wu, Li Lin, Emma X. P. Pu
Qualitative Evaluation Of A Service Leadership Subject In A Chinese Context, Daniel T. L. Shek, Jing Wu, Li Lin, Emma X. P. Pu
Pediatrics Faculty Publications
Adopting a qualitative methodology, views of the students on a subject on service leadership were examined. Students taking the subject (n=153) were invited to use descriptors and metaphors to describe their experiences about the subject. Regarding the descriptors given by the students, most of them were positive in nature. Similar positive findings were obtained for the metaphors. The findings are generally consistent with those studies using the same methodology reported in the literature. In conjunction with other evaluation findings, the present findings suggest that students had positive experiences about taking the subject and regarded the subject to be able to …
Correlates Of Sexual-Risk Behaviors Among Young Black Msm: Implications For Clinic-Based Counseling Programs, Richard A. Crosby, Leandro Mena, Janelle M. Ricks
Correlates Of Sexual-Risk Behaviors Among Young Black Msm: Implications For Clinic-Based Counseling Programs, Richard A. Crosby, Leandro Mena, Janelle M. Ricks
Health, Behavior & Society Faculty Publications
This study applied an 8-item index of recent sexual-risk behaviors to young Black men who have sex with men (YBMSM) and evaluated the distribution for normality. The distribution was tested for associations with possible antecedents of sexual risk. YBMSM (N = 600), aged 16–29 years, were recruited from a sexually transmitted infection clinic, located in the southern US. Men completed an extensive audio computer-assisted self-interview. Thirteen possible antecedents of sexual risk, as assessed by the index, were selected for analyses. The 8-item index formed a normal distribution with a mean of 4.77 (SD = 1.77). In adjusted analyses, not …
Subjective Report Of Side Effects Of Prescribed And Nonprescribed Psychostimulant Use In Young Adults, Tess E. Smith, Michelle M. Martel, Alan D. Desantis
Subjective Report Of Side Effects Of Prescribed And Nonprescribed Psychostimulant Use In Young Adults, Tess E. Smith, Michelle M. Martel, Alan D. Desantis
Psychology Faculty Publications
Background: Side effects of prescribed and nonprescribed psychostimulant use are understudied. Objectives: The study examined side effects of prescribed and nonprescribed psychostimulant use in a college sample with attention to possible gender differences. Methods: 2716 undergraduates (1448 male) between the ages of 17 and 57 years (M = 19.43 years, SD = 1.7 years) completed an online survey that included questions about the subjective side effects of prescribed and nonprescribed psychostimulant use. Results: Results suggested that prescribed users more frequently reported side effects, compared to nonprescribed users. For prescribed users, females more frequently reported appetite, somatic, and anxiety-related side …
Hope, Aspirations, And Resilience In Children And Adolescents: A Review Of Research On Measurement And Related Antecedents, Hildie Leung, Florence K. Y. Wu, Daniel T. L. Shek
Hope, Aspirations, And Resilience In Children And Adolescents: A Review Of Research On Measurement And Related Antecedents, Hildie Leung, Florence K. Y. Wu, Daniel T. L. Shek
Pediatrics Faculty Publications
Hope, aspirations, and resilience are important developmental assets for children and adolescents. Based on the existing Western and Chinese literature, this review aims to identify instruments used to assess hope, aspirations, resilience, and conceptually related constructs as well as antecedents of the constructs in adolescents. A systematic literature search in the major databases was conducted. A total of 223 articles, with 144 being retrieved from international databases and 79 from China’s database, met the criteria and were included in the present review. Findings revealed that the majority of the existing scales were developed predominantly in the West and there were …
Dreams, Aspirations And Related Constructs In Children And Adolescents: A Literature Review, Daniel T. L. Shek, Florence K. Y. Wu, Hildie Leung
Dreams, Aspirations And Related Constructs In Children And Adolescents: A Literature Review, Daniel T. L. Shek, Florence K. Y. Wu, Hildie Leung
Pediatrics Faculty Publications
Although children and adolescents are often asked about their “dreams” about life, scientific studies of “dreams” and related constructs are grossly inadequate. This paper describes the findings arising from a review study exploring the concepts of dreams, aspirations and related constructs in children and adolescents. Besides an overview of the concept of dream, conceptual features and unique underpinnings of other concepts commonly related to dream, such as “aspirations”, “hope”, “future orientation” and “resilience” are presented in this paper. The research questions surrounding “dream” and related constructs in children and adolescents are presented and future research directions are discussed.
Poland’S Voivodeships And Poviats And The Geographies Of Knowledge: Addressing Uneven Human Resources, Stanley D. Brunn, Marcin Semczuk, Rafał Koszek, Karolina Gołuszka, Gabriela Bołoz
Poland’S Voivodeships And Poviats And The Geographies Of Knowledge: Addressing Uneven Human Resources, Stanley D. Brunn, Marcin Semczuk, Rafał Koszek, Karolina Gołuszka, Gabriela Bołoz
Geography Faculty Publications
In a postindustrial economic world, information economies are key components in local, regional and national development. These are service economies, built on the production, consumption and dissemination of information, including education, health care, outsourcing, tourism, sustainability and related human welfare services. We explore the geography/knowledge intersections in Poland’s voivodeships and poviats by using the volumes of information or hyperlinks about selected information economies. Google hyperlinks are electronic knowledge data that can be mapped to highlight the areas of most and least information about certain subject categories. While some mapping results are expected, such as Warsaw and Krakow, being prominent, in …
Dreams, Aspirations And Related Behavior In Children And Adolescents: Impacts On Child Developmental Outcomes, Florence K. Y. Wu, Daniel T. L. Shek, Hildie Leung
Dreams, Aspirations And Related Behavior In Children And Adolescents: Impacts On Child Developmental Outcomes, Florence K. Y. Wu, Daniel T. L. Shek, Hildie Leung
Pediatrics Faculty Publications
“Dreams”, “aspirations” and related constructs are traditionally regarded as facilitators of adolescent educational attainment in the Chinese context. Besides, there is an emergent need to widen the understanding of such constructs and their impact on children and adolescent developmental outcomes. This paper discusses the developmental outcomes of dreams, aspiration and related concepts based on a thorough review of the literature. Besides outlining the impacts of aspirations, dreams and related constructs on children and adolescents, features of related intervention programs, including themes of the intervention programs, program participants, methods of implementation and evaluation in both Western and Chinese contexts are also …
Caloric Restriction Preserves Memory And Reduces Anxiety Of Aging Mice With Early Enhancement Of Neurovascular Functions, Ishita Parikh, Janet Guo, Kai-Hsiang Chuang, Yu Zhong, Ralf G. Rempe, Jared D. Hoffman, Rachel Armstrong, Björn Bauer, Anika M. S. Hartz, Ai-Ling Lin
Caloric Restriction Preserves Memory And Reduces Anxiety Of Aging Mice With Early Enhancement Of Neurovascular Functions, Ishita Parikh, Janet Guo, Kai-Hsiang Chuang, Yu Zhong, Ralf G. Rempe, Jared D. Hoffman, Rachel Armstrong, Björn Bauer, Anika M. S. Hartz, Ai-Ling Lin
Sanders-Brown Center on Aging Faculty Publications
Neurovascular integrity plays an important role in protecting cognitive and mental health in aging. Lifestyle interventions that sustain neurovascular integrity may thus be critical on preserving brain functions in aging and reducing the risk for age-related neurodegenerative disorders. Here we show that caloric restriction (CR) had an early effect on neurovascular enhancements, and played a critical role in preserving vascular, cognitive and mental health in aging. In particular, we found that CR significantly enhanced cerebral blood flow (CBF) and blood-brain barrier function in young mice at 5-6 months of age. The neurovascular enhancements were associated with reduced mammalian target of …