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Social and Behavioral Sciences Commons™
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Full-Text Articles in Social and Behavioral Sciences
Cerebral Hemodynamics After Short- And Long-Term Reduction In Blood Pressure In Mild And Moderate Hypertension, Rong Zhanf, Sarah Witkowski, Qi Fu, Jurgen A.H.R. Claassen, Benjamin D. Levine
Cerebral Hemodynamics After Short- And Long-Term Reduction In Blood Pressure In Mild And Moderate Hypertension, Rong Zhanf, Sarah Witkowski, Qi Fu, Jurgen A.H.R. Claassen, Benjamin D. Levine
Exercise and Sport Studies: Faculty Publications
This study tested the hypothesis that acute reduction in blood pressure (BP) at the initial stage of antihypertensive therapy compromises brain perfusion and dynamic cerebral autoregulation in patients with hypertension. Cerebral blood flow velocity and BP were measured in patients with mild and moderate hypertension and in healthy volunteers at baseline upon reduction of BP within 1 to 2 weeks of administration of losartan/hydrochlorothiazide and after 3 to 4 months of treatment. The transfer function between beat-to-beat changes in BP and cerebral blood flow velocity was estimated to assess dynamic autoregulation. After 1 to 2 weeks of treatment, BP was …
Inhibition Of Nitric Oxide Inhibition Of Nitric Oxide Synthase Does Not Alter Dynamic Cerebral Autoregulation In Humans, Rong Zhang, Thad E. Wilson, Sarah Witkowski, Jian Cui, Craig G. Crandall, Benjamin D. Levine
Inhibition Of Nitric Oxide Inhibition Of Nitric Oxide Synthase Does Not Alter Dynamic Cerebral Autoregulation In Humans, Rong Zhang, Thad E. Wilson, Sarah Witkowski, Jian Cui, Craig G. Crandall, Benjamin D. Levine
Exercise and Sport Studies: Faculty Publications
The aim of this study was to determine whether inhibition of nitric oxide synthase (NOS) alters dynamic cerebral autoregulation in humans. Beat-to-beat blood pressure (BP) and cerebral blood flow (CBF) velocity (transcranial Doppler) were measured in eight healthy subjects in the supine position and during 60° head-up tilt (HUT). NOS was inhibited by intravenous N G-monomethyl-L-arginine (L-NMMA) infusion. Dynamic cerebral autoregulation was quantified by transfer function analysis of beat-to-beat changes in BP and CBF velocity. Pressor effects of L-NMMA on cerebral hemodynamics were compared with those of phenylephrine infusion. In the supine position, L-NMMA increased mean BP from 83 ± …