Social and Behavioral Sciences Commons^™

Gut Microbiota-Derived Trimethylamine N-Oxide Contributes To Abdominal Aortic Aneurysm Through Inflammatory And Apoptotic Mechanisms, Tyler W. Benson, Kelsey A. Conrad, Xinmin S. Li, Zeneng Wang, Robert N. Helsley, Rebecca C. Schugar, Taylor M. Coughlin, Caris Wadding-Lee, Salma Fleifil, Hannah M. Russell, Timothy Stone, Michael Brooks, Jennifer A. Buffa, Kevin Mani, Martin Björck, Anders Wanhainen, Naseer Sangwan, Sudha Biddinger, Rohan Bhandari, Akiirayi Ademoya, Crystal Pascual, W. H.Wilson Tang, Michael Tranter, Scott J. Cameron, J. Mark Brown, Stanley L. Hazen, A. Phillip Owens

Exercise and Sport Studies: Faculty Publications

Background: Large-scale human and mechanistic mouse studies indicate a strong relationship between the microbiome-dependent metabolite trimethylamine N-oxide (TMAO) and several cardiometabolic diseases. This study aims to investigate the role of TMAO in the pathogenesis of abdominal aortic aneurysm (AAA) and target its parent microbes as a potential pharmacological intervention. Methods: TMAO and choline metabolites were examined in plasma samples, with associated clinical data, from 2 independent patient cohorts (N=2129 total). Mice were fed a high-choline diet and underwent 2 murine AAA models, angiotensin II infusion in low-density lipoprotein receptor-deficient (Ldlr-/-) mice or topical porcine pancreatic elastase in C57BL/6J mice. Gut …