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Full-Text Articles in Social and Behavioral Sciences
The Role Of Glucagon-Like Peptide-1 On Food Intake, Glucokinase Expression And Fatty Acid Metabolism, Hanjie Zhang
The Role Of Glucagon-Like Peptide-1 On Food Intake, Glucokinase Expression And Fatty Acid Metabolism, Hanjie Zhang
LSU Master's Theses
The increase in blood levels of GLP-1 with dietary resistant starch is thought to be associated with the activities of hypothalamic NPY/AgRP neurons and the gene expression of glucokinase in the ARC of the hypothalamus. Exendin-4 has been shown to be associated with fatty acid synthesis and oxidation. In this project, it was proposed that 1) food intake will be decreased in GLP-1R KO mice, the glucokinase (GK) mRNA expression in the liver and in the hypothalamus, the hypothalamic NPY mRNA expression will be up-regulated by exendin-4 treatment; and 2) exendin-4 will decrease fatty acid synthesis and increase fatty acid …