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A Multi-Site, Double-Blind, Placebo-Controlled Pilot Clinical Trial To Evaluate The Efficacy Of Buspirone As A Relapse-Prevention Treatment For Cocaine Dependence, Theresa M. Winhusen, Frankie Kropp, Robert Lindblad, Antoine Douaihy, Louise Haynes, Candace Hodgkins, Karen G. Chartier
A Multi-Site, Double-Blind, Placebo-Controlled Pilot Clinical Trial To Evaluate The Efficacy Of Buspirone As A Relapse-Prevention Treatment For Cocaine Dependence, Theresa M. Winhusen, Frankie Kropp, Robert Lindblad, Antoine Douaihy, Louise Haynes, Candace Hodgkins, Karen G. Chartier
Social Work Publications
Objective—To evaluate the potential efficacy of buspirone as a relapse-prevention treatment for cocaine dependence.
Method—A randomized, double-blind, placebo-controlled, 16-week pilot trial conducted at six clinical sites between August 2012 and June 2013. Adult crack cocaine users meeting DSM-IVTR criteria for current cocaine dependence scheduled to be in inpatient/residential substance use disorder (SUD) treatment for 12–19 days when randomized, and planning to enroll in local outpatient treatment through the end of the active treatment phase were randomized to buspirone titrated to 60 mg/day (n=35) or to placebo (n=27). All participants received psychosocial treatment as usually provided by the SUD treatment programs …