Social and Behavioral Sciences Commons^™

Age-Related Differences In The Association Between Stereotypic Behaviour And Salivary Cortisol In Young Males With An Autism Spectrum Disorder, Vicki Bitsika, Christopher Sharpley, Linda Agnew, Nicholas Andronicos

Vicki Bitsika

To identify if age influenced the relationship between one of the central symptoms of Autism Spectrum Disorder (ASD) and physiological stress, the association between stereotypic behaviour (SB) and stress-related cortisol concentrations was examined in a sample of 150 young males with an ASD. Parent-rated SB was significantly correlated with cortisol concentrations for boys aged 6 years to 12 years but not for adolescents aged 13 years to 18 years. This age-related difference in this association was not a function of cortisol concentrations but was related to differences in SB across these two age groups. IQ did not have a significant …

Which Aspects Of Sensory Features Are Associated With Elevated Cortisol Concentrations In Boys With An Autism Spectrum Disorder?, Vicki Bitsika, Christopher Sharpley, Nicholas Andronicos, Linda Agnew, Richard Mills

Vicki Bitsika

Difficulties in Sensory Features (SF) have been included in the most recent diagnostic processes for Autism Spectrum Disorder (ASD) and are more common in children with an ASD than their non-ASD peers. In addition, these difficulties with SF have been suggested as causing elevated stress and concentrations of salivary cortisol in young people with an ASD. However, previous studies have not examined the specific aspects of SF that are associated with elevated cortisol and that was the focus of this study with 135 boys with an ASD aged 6–18 years. The boys’ mothers assessed their sons’ SF with the Sensory …

Eight-Month Test-Retest Agreement In Morning Salivary Cortisol, Self- And Parent-Rated Anxiety In Boys With An Autism Spectrum Disorder, Christopher Sharpley, Vicki Bitsika, Linda Agnew, Nicholas Andronicos

Vicki Bitsika

The agreement over time in morning salivary cortisol concentrations and also self- and parent-rated anxiety was investigated in a sample of 16 boys with an ASD. Cortisol and anxiety data were collected eight months apart. Results indicated that there were significant correlations between each pair of measures from the two occasions, suggesting that cortisol concentrations and anxiety did not vary much at all over that time, challenging the assumption that cortisol needs to be measured over multiple days to obtain reliable data from children with an ASD. Implications for research into the ways these children respond to chronic stressors are …

Agreement Between Self- Vs Parent-Ratings Of General Anxiety Disorder Symptoms And Salivary Cortisol In Boys With An Asd, Vicki Bitsika, Christopher Sharpley, Nicholas Andronicos, Linda Agnew

Vicki Bitsika

To determine the relative validity of parent-assessed and self-assessed symptoms of Generalised Anxiety Disorder (GAD) in boys with an Autism Spectrum Disorder (ASD). 140 boys with an Autism Spectrum Disorder (ASD) were assessed for GAD by their parents and by themselves, and gave a sample of cortisol during the afternoon of these assessments. There were significant differences between self-assessments and parents’ assessments for the total GAD score and on four of the eight individual GAD symptoms. Using cortisol concentrations as a validation index, the two key GAD items were most validly assessed via boys’ self-ratings. Key GAD symptoms in boys …

Experiences Of Australian Siblings Of An Individual With An Autism Spectrum Disorder, Vicki Bitsika, Christopher Sharpley, Rebecca Mailli

Vicki Bitsika

The experiences of 75 non-Autism Spectrum Disorder (NASD) children and adolescents who had a sibling with an Autism Spectrum Disorder (ASD) were investigated. Differences were found according to age and gender for issues such as amount of time spent with their sibling and access to parents. Having a younger sibling with an ASD was associated with a lower level of confidence in being able to live their lives as they wished. Female NASD participants commented that their lives were more influenced than male NASD participants. About half of all NASD participants reported inconsistencies in family rule adherences and parental expectation.

Medicalization Of Depression, Anxiety, Schizophrenia, Adhd, Childhood Bipolar Disorder And Tantrums: Scientific Breakthrough, Or Broad-Based Delusion?, W. Wyatt

W. Joseph Wyatt

Clearly, a number of psychological and behavioral disorders arise within our biology. These include autism, Down’s syndrome, those due to toxin exposure, metabolic and endocrine difficulties, and several others. In contrast, there is minimal research evidence to support biological origins of the vast number of common disorders such as depression, anxiety disorders, schizophrenia or child problems such as conduct disorders, attention deficit hyperactivity disorder (ADHD), childhood bipolar disorder, oppositional behaviors or tantrums. These disorders have been medicalized when, in the absence of supportive research evidence, they are said to be caused by genetic defects, chemical imbalances or other biological phenomena. …

Hypothalamus–Pituitary–Adrenal Axis Daily Fluctuation, Anxiety And Age Interact To Predict Cortisol Concentrations In Boys With An Autism Spectrum Disorder, Vicki Bitsika, Christopher Sharpley, Nicholas Andronicos, Linda Agnew

Vicki Bitsika

There is considerable evidence of a confound between symptoms of generalised anxiety disorder (GAD) and autism spectrum disorder (ASD) in children who have an ASD. Although there have been several attempts to describe how these two disorders overlap and interact to influence the assessment and diagnosis of children with an ASD, principally by reference to cortisol assayed from these children's saliva, the overall evidence is inconsistent. Because previous models of these relationships have focused upon cortisol and GAD to the exclusion of age, diurnal fluctuation in the HPA axis and the source of GAD data, these variables were examined in …

Shared And Idiosyncratic Cortical Activation Patterns In Autism Revealed Under Continuous Real-Life Viewing Conditions, Uri Hasson, Galia Avidan, Hagar Gelbard, Ignacio Vallines, Michal Harel, Nancy Minshew, Marlene Behrmann

Marlene Behrmann

Although widespread alterations in cortical structure have been documented in individuals with autism, the functional implications of these alterations remain to be determined. Here, we adopted a novel inter-subject correlation (inter-SC) and intra-subject correlation (intra-SC) technique to quantify the reliability of the spatio-temporal responses of functional MR activity in adults with autism during free-viewing of a popular audio–visual movie. Whereas these complex stimuli evoke highly reliable shared response time courses in typical individuals, cortical activity was more variable across individuals with autism (low inter-SC). Interestingly, when we measured the responses within an autistic individual across repeated presentations of the movie, …

Practice Makes Improvement: How Adults With Autism Out-Perform Others In A Naturalistic Visual Search Task, Cleotilde Gonzalez, Jolie Martin, Nancy Minshew, Marlene Behrmann

Marlene Behrmann

People with autism spectrum disorder (ASD) often exhibit superior performance in visual search compared to others. However, most studies demonstrating this advantage have employed simple, uncluttered images with fully visible targets. We compare the performance of high-functioning adults with ASD and matched controls on a naturalistic luggage screening task. Although the two groups were equally accurate in detecting targets, the ASD adults improve in their correct elimination of target-absent bags faster than controls. This feature of their behavior is extremely important for many real-world monitoring tasks that require sustained attention for long time periods. Further analyses suggest that this improvement …

Endogenous Spatial Attention: Evidence For Intact Functioning In Adults With Autism, Michael Grubb, Marlene Behrmann, Ryan Egan, Nancy Minshew, Marisa Carrasco, David Heeger

Marlene Behrmann

Rapid manipulation of the attention field (i.e. the location and spread of visual spatial attention) is a critical aspect of human cognition, and previous research on spatial attention in individuals with autism spectrum disorders (ASD) has produced inconsistent results. In a series of three psychophysical experiments, we evaluated claims in the literature that individuals with ASD exhibit a deficit in voluntarily controlling the deployment and size of the spatial attention field. We measured the spatial distribution of performance accuracies and reaction times to quantify the sizes and locations of the attention field, with and without spatial uncertainty (i.e. the lack …

The Anatomy Of The Callosal And Visual-Association Pathways In High-Functioning Autism: A Dti Tractography Study, Cibu Thomas, Kate Humphreys, Kwan-Jin Jung, Nancy Minshew, Marlene Behrmann

Marlene Behrmann

There is increasing recognition that many of the core behavioral impairments that characterize autism potentially emerge from poor neural synchronization across nodes comprising dispersed cortical networks. A likely candidate for the source of this atypical functional connectivity in autism is an alteration in the structural integrity of intra- and inter-hemispheric white matter (WM) tracts that form large-scale cortical networks. To test this hypothesis, in a group of adults with high-functioning autism (HFA) and matched control participants, we used diffusion tensor tractography to compare the structural integrity of three intra-hemispheric visual-association WM tracts, the inferior longitudinal fasciculus (ILF), the inferior fronto-occipito …

Aberrant Functioning Of The Theory-Of-Mind Network In Children And Adolescents With Autism., Rajesh Kana, Jose Maximo, Diane Williams, Timothy Keller, Sarah Schipul, Vladimir Cherkassky, Nancy Minshew, Marcel Just

Marcel Adam Just