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Full-Text Articles in Social and Behavioral Sciences
Dose-Related Sex Differences In The Establishment Of Conditioned Disgust (Anticipatory Nausea), And The Effect Of Peripubertal And Adult Immune System Stimulation With The Endotoxin Lipopolysaccharide (Lps) On Learning And Memory In The Rat, Caylen J. Cloutier
Electronic Thesis and Dissertation Repository
This thesis examined sex differences in the establishment of lithium chloride (LiCl) – induced conditioned disgust behavior (anticipatory nausea) to a distinct context, as well as, the establishment of conditioned place avoidance (CPA) using rodent models. Also examined were potential sex differences in response to treatment with the bacterial endotoxin, lipopolysaccharide (LPS), and its effect on learning and memory. In Chapter 2, male and female naïve Long-Evans rats were injected (intraperitoneally; i.p.) with either 200 µg/kg LPS or 0.9% (NaCl), 90 minutes prior to i.p. injections of either 128 mg/kg LiCl or 0.9% NaCl, and immediately placed into a distinctive …
Social Factors Modulate Toxin (Licl)-Induced Conditioned Disgust Responses In Male Rats, Nathalie Boulet
Social Factors Modulate Toxin (Licl)-Induced Conditioned Disgust Responses In Male Rats, Nathalie Boulet
Electronic Thesis and Dissertation Repository
Rats, which are a non-emetic species, display conditioned disgust responses when re-exposed to a context previously associated with sickness. These conditioned disgust responses can be used to model anticipatory nausea in humans, a growing problem faced by numerous chemotherapy patients. This thesis found that social factors, in addition to contextual factors, can play a role in the expression of toxin (LiCl)-induced conditioned disgust in rats. The results show that a familiar, but not unfamiliar, social partner can serve as a cue for the display of conditioned gaping. Further, a variety of sensory cues may play a role in the development …