Social and Behavioral Sciences Commons^™

Gene-Environment Interactions In Attention Deficit Hyperactivity Disorder, Holly Donovan Barnard

Electronic Theses and Dissertations

The overall goal of this project is to advance our understanding of the multifactorial etiology of Attention Deficit Hyperactivity Disorder (ADHD) by testing a diathesis-stress model of gene x environment (g x e) interactions. Although the literature increasingly supports g x e interactions in the manifestation of ADHD, few studies have investigated multiple genetic and environmental risk factors, included direct tests of gene - environment correlations (rG-Es), explored the specificity of interactions to symptom dimensions, or attempted to minimize comparisons. Therefore, utilizing both within-family (FBAT/PBAT) and case-control methodology, this study sought to (1) explore main effects of polymorphisms in the …