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Effects Of Early Adolescent Exposure To D-Amphetamine In A Rodent Model Of Nicotine Reward, Eric Louis Harvey

Dissertations

Previous studies with rodents have found that adolescent exposure to psychoactive drugs can alter neurophysiology and produce behavioral effects that persist into adulthood. While several studies have examined the effects of adolescent exposure to nicotine on the subsequent rewarding value of various drugs of abuse in adulthood, to date, no known studies have examined the converse of this relationship. d-Amphetamine (i.e., dextroamphetamine, ProCentra®) is a potent psychostimulant that is commonly used in the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) in adolescents. The present study assessed the effects of adolescent exposure to d-amphetamine on the rewarding value of nicotine in …