Social and Behavioral Sciences Commons^™

Striatal Activity Is Associated With Deficits Of Cognitive Control And Aberrant Salience For Patients With Schizophrenia, Alan E. Ceaser

Arts & Sciences Electronic Theses and Dissertations

A recent study has shown that the locus of the largest known dopamine abnormality between patients with schizophrenia and healthy controls is in the associative striatum (Kegeles et al., 2010). This dopamine abnormality in the associative striatum is thought to bring about aberrant salience assignment for patients, which may underlie symptoms of psychosis like delusions and hallucinations (Howes & Kapur, 2009). Interestingly, the associative striatum has segregated, looped, connectivity with cortical regions including the prefrontal and parietal cortices (Draganski et al., 2008; Redgrave, Vautrelle, & Reynolds, 2011) and computational models have suggested that it may function as an information gate …