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A Comparison Of Nefazodone, The Cognitive Behavioral-Analysis System Of Psychotherapy, And Their Combination For The Treatment Of Chronic Depression, Martin B. Keller , M.D., James P. Mccullough , Ph.D., Daniel N. Klein , Ph.D., Bruce Arnow , Ph.D., David L. Dunner , M.D., Alan J. Gelenberg , M.D., John C. Markowitz , M.D., Charles B. Nemeroff , M.D., Ph.D., James M. Russell M.D., Michael E. Thase , M.D., Madhukar H. Trivedi , M.D., Janice A. Blalock , Ph.D., Frances E. Borian , R.N., Darlene N. Jody , M.D., Charles Debattista , D.M.H., M.D., Lorrin M. Koran , M.D., Alan F. Schatzberg , M.D., Jan Fawcett , M.D., Robert M.A. Hirschfeld , M.D., Gabor Keitner , M.D., Ivan Miller , Ph.D., James H. Kocsis , M.D., Susan G. Kornstein , M.D., Rachel Manber , Ph.D., Philip T. Ninan , M.D., Barbara Rothbaum , Ph.D., A. John Rush , M.D., Dina Vivian , Ph.D., John Zajecka , M.D.

Psychology Publications

Background

Patients with chronic forms of major depression are difficult to treat, and the relative efficacy of medications and psychotherapy is uncertain.

Methods

We randomly assigned 681 adults with a chronic nonpsychotic major depressive disorder to 12 weeks of outpatient treatment with nefazodone (maximal dose, 600 mg per day), the cognitive behavioral-analysis system of psychotherapy (16 to 20 sessions), or both. At base line, all patients had scores of at least 20 on the 24-item Hamilton Rating Scale for Depression (indicating clinically significant depression). Remission was defined as a score of 8 or less at weeks 10 and 12. For …