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Full-Text Articles in Social and Behavioral Sciences
In Vivo And In Vitro Effects Of Vortioxetine On Molecules Associated With Neuroplasticity, Pirathiv Kugathasan, Jessica Waller, Ligia Westrich, Aicha Abdourahman, Joseph A. Tamm, Alan Pehrson, Elena Dale, Maria Gulinello, Connie Sanchez, Yan Li
In Vivo And In Vitro Effects Of Vortioxetine On Molecules Associated With Neuroplasticity, Pirathiv Kugathasan, Jessica Waller, Ligia Westrich, Aicha Abdourahman, Joseph A. Tamm, Alan Pehrson, Elena Dale, Maria Gulinello, Connie Sanchez, Yan Li
Department of Psychology Faculty Scholarship and Creative Works
Neuroplasticity is fundamental for brain functions, abnormal changes of which are associated with mood disorders and cognitive impairment. Neuroplasticity can be affected by neuroactive medications and by aging. Vortioxetine, a multimodal antidepressant, has shown positive effects on cognitive functions in both pre-clinical and clinical studies. In rodent studies, vortioxetine increases glutamate neurotransmission, promotes dendritic branching and spine maturation, and elevates hippocampal expression of the activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) at the transcript level. The present study aims to assess the effects of vortioxetine on several neuroplasticity-related molecules in different experimental systems. Chronic (1 month) vortioxetine increased Arc/Arg3.1 protein levels in the …
Chronic Vortioxetine Treatment In Rodents Modulates Gene Expression Of Neurodevelopmental And Plasticity Markers, Jessica A. Waller, Joseph A. Tamm, Aicha Abdourahman, Alan Pehrson, Yan Li, Manuel Cajina, Connie Sánchez
Chronic Vortioxetine Treatment In Rodents Modulates Gene Expression Of Neurodevelopmental And Plasticity Markers, Jessica A. Waller, Joseph A. Tamm, Aicha Abdourahman, Alan Pehrson, Yan Li, Manuel Cajina, Connie Sánchez
Department of Psychology Faculty Scholarship and Creative Works
The multimodal antidepressant vortioxetine displays an antidepressant profile distinct from those of conventional selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) and possesses cognitive-enhancing properties in preclinical and clinical studies. Recent studies have begun to investigate molecular mechanisms that may differentiate vortioxetine from other antidepressants. Acute studies in adult rats and chronic studies in a middle-aged mouse model reveal upregulation of several markers that play a central role in synaptic plasticity. However, the effect of chronic vortioxetine treatment on expression of neuroplasticity and neurodevelopmental biomarkers in naïve rats has not been evaluated. In the present study, we demonstrate …