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Full-Text Articles in Social and Behavioral Sciences
Neuroplasticity Pathways And Protein-Interaction Networks Are Modulated By Vortioxetine In Rodents, Jessica A. Waller, Sara Holm Nygaard, Yan Li, Kristian Gaarn Jardin, Joseph A. Tamm, Aicha Abdourahman, Betina Elfving, Alan Pehrson, Connie Sánchez, Rasmus Wernersson
Neuroplasticity Pathways And Protein-Interaction Networks Are Modulated By Vortioxetine In Rodents, Jessica A. Waller, Sara Holm Nygaard, Yan Li, Kristian Gaarn Jardin, Joseph A. Tamm, Aicha Abdourahman, Betina Elfving, Alan Pehrson, Connie Sánchez, Rasmus Wernersson
Department of Psychology Faculty Scholarship and Creative Works
Background: The identification of biomarkers that predict susceptibility to major depressive disorder and treatment response to antidepressants is a major challenge. Vortioxetine is a novel multimodal antidepressant that possesses pro-cognitive properties and differentiates from other conventional antidepressants on various cognitive and plasticity measures. The aim of the present study was to identify biological systems rather than single biomarkers that may underlie vortioxetine's treatment effects. Results: We show that the biological systems regulated by vortioxetine are overlapping between mouse and rat in response to distinct treatment regimens and in different brain regions. Furthermore, analysis of complexes of physically-interacting proteins reveal that …
Chronic Vortioxetine Treatment In Rodents Modulates Gene Expression Of Neurodevelopmental And Plasticity Markers, Jessica A. Waller, Joseph A. Tamm, Aicha Abdourahman, Alan Pehrson, Yan Li, Manuel Cajina, Connie Sánchez
Chronic Vortioxetine Treatment In Rodents Modulates Gene Expression Of Neurodevelopmental And Plasticity Markers, Jessica A. Waller, Joseph A. Tamm, Aicha Abdourahman, Alan Pehrson, Yan Li, Manuel Cajina, Connie Sánchez
Department of Psychology Faculty Scholarship and Creative Works
The multimodal antidepressant vortioxetine displays an antidepressant profile distinct from those of conventional selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) and possesses cognitive-enhancing properties in preclinical and clinical studies. Recent studies have begun to investigate molecular mechanisms that may differentiate vortioxetine from other antidepressants. Acute studies in adult rats and chronic studies in a middle-aged mouse model reveal upregulation of several markers that play a central role in synaptic plasticity. However, the effect of chronic vortioxetine treatment on expression of neuroplasticity and neurodevelopmental biomarkers in naïve rats has not been evaluated. In the present study, we demonstrate …