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Full-Text Articles in Social and Behavioral Sciences
A Longitudinal Study Evaluating The Effects Of Interferon-Alpha Therapy On Cognitive And Psychiatric Function In Adults With Chronic Hepatitis C, Marilyn Huckans, Bret Fuller, Viva Wheaton, Sarah Jaehnert, Carilyn Ellis, Michael Kolessar, Daniel Kriz, Jeanne Renee Anderson, Kristin Berggren, Hannah Olavarria, Anna W. Sasaki, Michael Chang, Kenneth D. Flora, Jennifer M. Loftis
A Longitudinal Study Evaluating The Effects Of Interferon-Alpha Therapy On Cognitive And Psychiatric Function In Adults With Chronic Hepatitis C, Marilyn Huckans, Bret Fuller, Viva Wheaton, Sarah Jaehnert, Carilyn Ellis, Michael Kolessar, Daniel Kriz, Jeanne Renee Anderson, Kristin Berggren, Hannah Olavarria, Anna W. Sasaki, Michael Chang, Kenneth D. Flora, Jennifer M. Loftis
Faculty Publications - Doctor of Psychology (PsyD) Program
Objective: To prospectively evaluate for changes in objective cognitive performance (attention, memory, and executive function) and psychiatric symptom severity (depression, anxiety, fatigue, and pain) in patients before, during and after interferon-alpha based therapy (IFN) for chronic hepatitis C virus infection (HCV).
Methods: 33 HCV+ adults were evaluated two months before IFN initiation (baseline), three months into IFN, and six months following IFN termination (IFN+ Group). 31 HCV+ adults who did not undergo IFN therapy were evaluated at baseline and six months later (IFN− Group). At each evaluation, participants completed the Neuropsychological Assessment Battery (NAB) Attention, Memory and Executive Functions Modules, …