Social and Behavioral Sciences Commons^™

Early Rearing Conditions Affect Monoamine Metabolite Levels During Baseline And Periods Of Social Separation Stress: A Non-Human Primate Model (Macaca Mulatta), Elizabeth K. Wood, Natalia Gabrielle, Jacob Hunter, Andrea N. Skowbo, Melanie L. Schwandt, Stephen G. Lindell, Christina S. Barr, Stephen J. Suomi, James Dee Higley

Faculty Publications

A variety of studies show that parental absence early in life leads to deleterious effects on the developing CNS. This is thought to be largely because evolutionary-dependent stimuli are necessary for the appropriate postnatal development of the young brain, an effect sometimes termed the “experience-expectant brain,” with parents providing the necessary input for normative synaptic connections to develop and appropriate neuronal survival to occur. Principal among CNS systems affected by parental input are the monoamine systems. In the present study, N = 434 rhesus monkeys (233 males, 201 females) were reared in one of two conditions: as mother-reared controls (MR; …