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Basal forebrain; fasciculus retroflexus; microglial activation; efferent connections; prefrontal cortex; paradoxical sleep; dopamine release; medial habenula;drinking; nucleus
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Full-Text Articles in Social and Behavioral Sciences
Adolescent, But Not Adult, Binge Ethanol Exposure Leads To Persistent Global Reductions Of Choline Acetyltransferase Expressing Neurons In Brain, Ryan P. Vetreno, Margaret Broadwater, Wen Liu, Linda Spear, Fulton T. Crews
Adolescent, But Not Adult, Binge Ethanol Exposure Leads To Persistent Global Reductions Of Choline Acetyltransferase Expressing Neurons In Brain, Ryan P. Vetreno, Margaret Broadwater, Wen Liu, Linda Spear, Fulton T. Crews
Psychology Faculty Scholarship
During the adolescent transition from childhood to adulthood, notable maturational changes occur in brain neurotransmitter systems. The cholinergic system is composed of several distinct nuclei that exert neuromodulatory control over cognition, arousal, and reward. Binge drinking and alcohol abuse are common during this stage, which might alter the developmental trajectory of this system leading to long-term changes in adult neurobiology. In Experiment 1, adolescent intermittent ethanol (AIE; 5.0 g/kg, i.g., 2-day on/2-day off from postnatal day [P] 25 to P55) treatment led to persistent, global reductions of choline acetyltransferase (ChAT) expression. Administration of the Toll-like receptor 4 agonist lipopolysaccharide to …