Social and Behavioral Sciences Commons^™

Thalamic Shape Abnormalities Differentially Relate To Cognitive Performance In Early-Onset And Adult-Onset Schizophrenia, Derin J. Cobia, Chaz Rich, Matthew J. Smith, Pedro Engel Gonzalez, Will Cronenwett, John G. Csernansky, Lei Wang

Faculty Publications

Early-onset schizophrenia (EOS) shares many biological and clinical features with adult-onset schizophrenia (AOS), but may represent a unique subgroup with greater susceptibility for disease onset and worsened symptomatology and progression, which could potentially derive from exaggerated neurodevelopmental abnormalities. Neurobiological explanations of schizophrenia have emphasized the involvement of deep-brain structures, particularly alterations of the thalamus, which have been linked to core features of the disorder. The aim of this study was to compare thalamic shape abnormalities between EOS and AOS subjects and determine whether unique behavioral profiles related to these differences. It was hypothesized abnormal thalamic shape would be observed in …

Cognitive Empathy And Longitudinal Changes In Temporo-Parietal Junction Thickness In Schizophrenia, Derin J. Cobia, Tatiana Karpouzian-Rogers, Julie Petersen, Lei Wang, Vijay A. Mittal, John G. Csernansky, Matthew J. Smith

Faculty Publications

Objective: Deficits in cognitive empathy are well-documented in individuals with schizophrenia and are related to reduced community functioning. The temporoparietal junction (TPJ) is closely linked to cognitive empathy. We compared the relationship between baseline cognitive empathy and changes in TPJ thickness over 24 months between individuals with schizophrenia and healthy controls. Methods: Individuals with schizophrenia (n = 29) and healthy controls (n = 26) completed a cognitive empathy task and underwent structural neuroimaging at baseline and approximately 24 months later. Symmetrized percent change scores were calculated for right and left TPJ, as well as whole-brain volume, and compared between groups. …

Impact Of Acute Sleep Restriction On Cerebral Glucose Metabolism During Recovery Non-Rapid Eye Movement Sleep Among Individuals With Primary Insomnia And Good Sleeper Controls, Daniel Kay, Helmet T. Karim, Brant P. Hasle, Jeffrey A. James, Anne Germain, Martica H. Hall, Peter L. Franzen, Julie C. Price, Eric A. Nofzinger, Daniel J. Buysse

Faculty Publications

Background: Restricting time in bed improves insomnia symptoms, but the neural mechanisms for this effect are unknown. Total and partial acute sleep restriction may be useful paradigms for elucidating these effects. We examined the impact of acute sleep restriction on cerebral glucose metabolism during non-rapid eye movement (NREM) sleep in individuals with primary insomnia (PI; n=17) and good sleep (GS; n=19).

Methods: Participants underwent [18F]fluorodeoxyglucose positron emission tomography (FDGPET) scans during baseline and recovery NREM sleep following one night of partial or total sleep restriction. We compared group differences (PI vs. GS) in baseline-recovery changes, as well as main effects …

Hyperarousal And Beyond: New Insights To The Pathophysiology Of Insomnia Disorder Through Functional Neuroimaging Studies, Daniel Kay, Daniel J. Buysse

Faculty Publications

Neuroimaging studies have produced seemingly contradictory findings in regards to the pathophysiology of insomnia. Although most study results are interpreted from the perspective of a “hyperarousal” model, the aggregate findings from neuroimaging studies suggest a more complex model is needed. We provide a review of the major findings from neuroimaging studies, then discuss them in relation to a heuristic model of sleep-wake states that involves three major factors: wake drive, sleep drive, and level of conscious awareness. We propose that insomnia involves dysregulation in these factors, resulting in subtle dysregulation of sleep-wake states throughout the 24 h light/dark cycle.

Conceptualizing The Neurobiology Of Non-Suicidal Self-Injury From The Perspective Of The Research Domain Criteria Project, Scott R. Braithwaite, Melinda Westlund Schreiner, Bonnie Klimes-Dougan, Erin D. Begnel, Kathryn R. Cullen

Faculty Publications

Non-suicidal self-injury (NSSI) commonly starts in adolescence and is associated with an array of negative outcomes. Neurobiological research investigating NSSI is in its early stages and most studies have examined this behavior within the context of specific diagnoses. However, the Research Domain Criteria (RDoC) initiative encourages researchers to examine brain-behavior relationships across diagnoses. This review on the neurobiology associated with NSSI is organized using the domains proposed by RDoC: Negative Valence, Positive Valence, Cognitive, Social Processes, and Arousal/Regulatory Systems. Evidence of neurobiological anomalies is found in each of these domains. We also propose future research directions, especially in regard to …

Cannabis-Related Episodic Memory Deficits And Hippocampal Morphological Differences In Healthy Individuals And Schizophrenia Subjects, Derin J. Cobia, Matthew J. Smith, James L. Reilly, Jodi Gilman, Andrea G. Roberts, Kathryn I. Alpert, Lei Wang, Hans C. Breiter, John G. Csernansky

Faculty Publications

Cannabis use has been associated with episodic memory (EM) impairments and abnormal hippocampus morphology among both healthy individuals and schizophrenia subjects. Considering the hippocampus' role in EM, research is needed to evaluate the relationship between cannabis-related hippocampal morphology and EM among healthy and clinical groups. We examined differences in hippocampus morphology between control and schizophrenia subjects with and without a past (not current) cannabis use disorder (CUD). Subjects group-matched on demographics included 44 healthy controls (CON), 10 subjects with a CUD history (CON-CUD), 28 schizophrenia subjects with no history of substance use disorders (SCZ), and 15 schizophrenia subjects with a …

Longitudinal Progression Of Frontal And Temporal Lobe Changes In Schizophrenia, Derin J. Cobia, Matthew J. Smith, Lei Wang, John G. Csernansky

Faculty Publications

Cortical abnormalities are considered a neurobiological characteristic of schizophrenia. However, the pattern of such deficits as they progress over the illness remains poorly understood. The goal of this project was to assess the progression of cortical thinning in frontal and temporal cortical regions in schizophrenia, and determine whether relationships exist between them and neuropsychological and clinical symptom profiles. As part of a larger longitudinal 2-year followup study, schizophrenia (n=20) and healthy participants (n=20) group-matched for age, gender, and recent-alcohol use, were selected. Using MRI, estimates of gray matter thickness were derived from primary anatomical gyri of the frontal and temporal …