Social and Behavioral Sciences Commons^™

Association Between Exposure To Air Pollution And Total Gray Matter And Total White Matter Volumes In Adults: A Cross-Sectional Study, Bruce L. Brown, Lance D. Erickson, Shawn D. Gale, Jacqueline E. Anderson, Dawson W. Hedges

Faculty Publications

Total brain gray-matter and white-matter volumes can be indicators of overall brain health. Among the factors associated with gray-matter and white-matter volumes is exposure to air pollution. Using data from the UK Biobank, we sought to determine associations between several components of air pollution—PM2.5, PM2.5–10, PM10, nitrogen dioxide, and nitrogen oxides—and total gray-matter and total white-matter volumes in multivariable regression models in a large sample of adults. We found significant inverse associations between PM2.5 concentration and total white-matter volume and between PM2.5, PM2.5–10, PM10, nitrogen dioxide, and nitrogen oxide concentrations and total gray-matter volume in models adjusted for age, sex, …

Association Between Exposure To Air Pollution And Thalamus Volume In Adults: A Crosssectional Study, Bruce L. Brown, Dawson W. Hedges, Lance D. Erickson, Shawn D. Gale, Jacqueline E. Anderson

Faculty Publications

Background: Air pollution has been associated with cognitive function and brain volume. While most previous research has examined the association between air pollution and brain volume in cortical structures or total brain volume, less research has investigated associations between exposure to air pollution and subcortical structures, including the thalamus. Further, the few available previous studies investigating associations between air pollution and thalamic volume have shown mixed results.

Methods: In this study, we evaluated the association between PM2.5, PM2.5–10, PM10, nitrogen dioxide, and nitrogen oxides and volume of the thalamus in adults using the UK Biobank resource, a large community-based sample, …