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Social and Behavioral Sciences Commons™
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Articles 1 - 2 of 2
Full-Text Articles in Social and Behavioral Sciences
Direct Visualization And Characterization Of The Human Zona Incerta And Surrounding Structures, Jonathan C. Lau, Yiming Xiao, Roy A.M. Haast, Greydon Gilmore, Kâmil Uludağ, Keith W. Macdougall, Ravi S. Menon, Andrew G. Parrent, Terry M. Peters, Ali R. Khan
Direct Visualization And Characterization Of The Human Zona Incerta And Surrounding Structures, Jonathan C. Lau, Yiming Xiao, Roy A.M. Haast, Greydon Gilmore, Kâmil Uludağ, Keith W. Macdougall, Ravi S. Menon, Andrew G. Parrent, Terry M. Peters, Ali R. Khan
Brain and Mind Institute Researchers' Publications
The zona incerta (ZI) is a small gray matter region of the deep brain first identified in the 19th century, yet direct in vivo visualization and characterization has remained elusive. Noninvasive detection of the ZI and surrounding region could be critical to further our understanding of this widely connected but poorly understood deep brain region and could contribute to the development and optimization of neuromodulatory therapies. We demonstrate that high resolution (submillimetric) longitudinal (T1) relaxometry measurements at high magnetic field strength (7 T) can be used to delineate the ZI from surrounding white matter structures, specifically the fasciculus cerebellothalamicus, fields …
Expanding The Search For Genetic Biomarkers Of Parkinson's Disease Into The Living Brain, Simon M. Benoit, Hu Xu, Susanne Schmid, Roumiana Alexandrova, Gaganjot Kaur, Bhooma Thiruvahindrapuram, Sergio L. Pereira, Mandar Jog, Matthew O. Hebb
Expanding The Search For Genetic Biomarkers Of Parkinson's Disease Into The Living Brain, Simon M. Benoit, Hu Xu, Susanne Schmid, Roumiana Alexandrova, Gaganjot Kaur, Bhooma Thiruvahindrapuram, Sergio L. Pereira, Mandar Jog, Matthew O. Hebb
Brain and Mind Institute Researchers' Publications
Altered gene expression related to Parkinson's Disease (PD) has not been described in the living brain, yet this information may support novel discovery pertinent to disease pathophysiology and treatment. This study compared the transcriptome in brain biopsies obtained from living PD and Control patients. To evaluate the novelty of this data, a comprehensive literature review also compared differentially expressed gene (DEGs) identified in the current study with those reported in PD cadaveric brain and peripheral tissues. RNA was extracted from rapidly cryopreserved frontal lobe specimens collected from PD and Control patients undergoing neurosurgical procedures. RNA sequencing (RNA-Seq) was performed and …