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Full-Text Articles in Social and Behavioral Sciences

Neurologists Look At Causes Of Baffling Brain Condition, Maggie Freleng Dec 2015

Neurologists Look At Causes Of Baffling Brain Condition, Maggie Freleng

Capstones

It can be hard getting help for someone with mental illness, but almost impossible when that person doesn't think they are sick. At at least half of people with schizophrenia, for example, insist that the voices they hear are real. People who do not know they are ill often refuse therapy and medication -- and their symptoms can spiral out of control. Doctors call this lack of awareness anosognosia. Neurologists are trying to discover what causes this baffling condition--and how to treat it.


How Can We Build A Moral Robot?, Kristen E. Clark Dec 2015

How Can We Build A Moral Robot?, Kristen E. Clark

Capstones

Artificial intelligence is already starting to drive our cars and make choices that affect the world economy. One day soon, we’ll have robots that can take care of our sick and elderly, and even rescue us in rescue us in emergencies. But as robots start to make decisions that matter—it’s raising questions that go far beyond engineering. We’re stating to think about ethics.

Bertram Malle and Matthias Scheutz are part of a team funded by the department of defense. It's their job to answer a question that seems straight out of a sci-fi novel: How can we build a moral …


You're Only As Good As You Do In School: Asian American Students And The Mental Risks They Face In Higher Education, Asia C. Ewart Dec 2015

You're Only As Good As You Do In School: Asian American Students And The Mental Risks They Face In Higher Education, Asia C. Ewart

Capstones

Anne Cai always joked that, “one of these days,” school was going to drive her to insanity. A snapshot of her life begged to differ. As the oldest of three daughters in her traditional Chinese­ American family, Anne, 23, was the image of success and achievement, not only for her parents and their peers, but for her sisters Jenny, 19, and Vicky, 13. She excelled in elementary, middle and at all three of her high schools—the high school moves were decided by her parents and she never questioned them, lest she burden the family with what she considered complaining.


Training A New Trick Using No-Reward Markers: Effects On Dogs’ Performance And Stress Behaviors, Naomi Rotenberg Dec 2015

Training A New Trick Using No-Reward Markers: Effects On Dogs’ Performance And Stress Behaviors, Naomi Rotenberg

Theses and Dissertations

This study explored using no-reward markers (NRMs). Dogs were taught a novel trick. In the IG group dogs’ errors were ignored; in the NRM group they elicited a tone. Performance and stress were evaluated. IG dogs reached higher levels of performance, with no difference in the frequency of stress behaviors.


Increases In Perspective Embedding Increase Reading Time Even With Typical Text Presentation: Implications For The Reading Of Literature, D. H. Whalen, Lisa Zunshine, Michael Holquist Nov 2015

Increases In Perspective Embedding Increase Reading Time Even With Typical Text Presentation: Implications For The Reading Of Literature, D. H. Whalen, Lisa Zunshine, Michael Holquist

Publications and Research

Reading fiction is a major component of intellectual life, yet it has proven difficult to study experimentally. One aspect of literature that has recently come to light is perspective embedding (“she thought I left” embedding her perspective on “I left”), which seems to be a defining feature of fiction. Previous work (Whalen et al., 2012) has shown that increasing levels of embedment affects the time that it takes readers to read and understand short vignettes in a moving window paradigm. With increasing levels of embedment from 1 to 5, reading times in a moving window paradigm rose almost linearly. However, …


Word-Length Correlations And Memory In Large Texts: A Visibility Network Analysis, Lev Guzmán-Vargas, Bibiana Obregón-Quintana, Daniel Aguilar-Velázquez, Ricardo Hernández-Pérez, Larry S. Liebovitch Nov 2015

Word-Length Correlations And Memory In Large Texts: A Visibility Network Analysis, Lev Guzmán-Vargas, Bibiana Obregón-Quintana, Daniel Aguilar-Velázquez, Ricardo Hernández-Pérez, Larry S. Liebovitch

Publications and Research

We study the correlation properties of word lengths in large texts from 30 ebooks in the English language from the Gutenberg Project (www.gutenberg.org) using the natural visibility graph method (NVG). NVG converts a time series into a graph and then analyzes its graph properties. First, the original sequence of words is transformed into a sequence of values containing the length of each word, and then, it is integrated. Next, we apply the NVG to the integrated word-length series and construct the network. We show that the degree distribution of that network follows a power law, P(k)∼k−γP(k)∼k-γ, with two regimes, which …


Daily Minority Stress And Affect Among Gay And Bisexual Men: A 30-Day Diary Study, Adam I. Eldahan, John E. Pachankis, H. Jonathan Rendina, Ana Ventuneac, Christian Grov, Jeffrey T. Parsons Oct 2015

Daily Minority Stress And Affect Among Gay And Bisexual Men: A 30-Day Diary Study, Adam I. Eldahan, John E. Pachankis, H. Jonathan Rendina, Ana Ventuneac, Christian Grov, Jeffrey T. Parsons

Publications and Research

Background. This study examined the time-variant association between daily minority stress and daily affect among gay and bisexual men. Tests of time-lagged associations allow for a stronger causal examination of minority stress-affect associations compared with static assessments. Multilevel modeling allows for comparison of associations between minority stress and daily affect when minority stress is modeled as a between-person factor and a within-person time-fluctuating state.

Methods. 371 gay and bisexual men in New York City completed a 30-day daily diary, recording daily experiences of minority stress and positive affect (PA), negative affect (NA), and anxious affect (AA). Multilevel analyses examined …


Variability, Stability, And Flexibility In The Speech Kinematics And Acoustics Of Adults Who Do And Do Not Stutter, Eric S. Jackson Sep 2015

Variability, Stability, And Flexibility In The Speech Kinematics And Acoustics Of Adults Who Do And Do Not Stutter, Eric S. Jackson

Dissertations, Theses, and Capstone Projects

It is well known that people who do and do not stutter produce speech differently, at least some of the time, even when perceived as fluent. One way that investigators have assessed these differences is by measuring variability, or the inconsistency of repeated speech movements. Variability in speech has typically been quantified using linear analysis techniques (e.g., measures of central tendency), and results have indicated that people who stutter produce speech that is (sometimes) characterized by increased variability. However, variability is a complex phenomenon, one that cannot be assessed by linear methods alone. This dissertation employs linear and nonlinear analysis …


Three Potential Mediators Of The Effects Of Child Abuse And Neglect On Smoking In Middle Adulthood, Miriam Ghirmay Sep 2015

Three Potential Mediators Of The Effects Of Child Abuse And Neglect On Smoking In Middle Adulthood, Miriam Ghirmay

Dissertations, Theses, and Capstone Projects

The purpose of the current study was fourfold: (1) to determine whether individuals with histories of child abuse and neglect have higher rates of current cigarette smoking in middle adulthood compared with matched controls; (2) to examine whether individuals with histories of abuse and/or neglect are at increased risk for higher rates of current psychopathology (anxiety or depression), negative coping, and past year traumas and victimization experiences in adulthood compared with matched controls; (3) to determine whether current psychopathology, negative coping, and past year traumas and victimization experiences mediate the relationship between child maltreatment and current smoking; and (4) to …


Development Of A Naturalistic Observational Parenting Practice Assessment Tool For Externalizing Behavior Research, Thailyn L. Alonso Sep 2015

Development Of A Naturalistic Observational Parenting Practice Assessment Tool For Externalizing Behavior Research, Thailyn L. Alonso

Dissertations, Theses, and Capstone Projects

Externalizing behavior problems have severe clinical implications. In fact, they have been found to be the primary basis for mental health referrals in early childhood. Findings from research on the etiology and development of externalizing behavior problems indicate these in addition to having significant effects throughout the life span effects also extend across multiple generations. Family and child development research consistently finds that one of the most significant modifiable factors in the prevention and treatment of externalizing behavior problems in early childhood is parenting practices. Unfortunately, much of the extant literature is limited by parenting measures that are prone to …


Art As Communication: Employing Gricean Principles Of Communication As A Model For Art Appreciation, Melissa June Dolese Sep 2015

Art As Communication: Employing Gricean Principles Of Communication As A Model For Art Appreciation, Melissa June Dolese

Dissertations, Theses, and Capstone Projects

Abstract

How and why artworks elicit varied preferences and judgments among different individuals remains a topic with many unresolved issues. For instance, individuals with little artistic experience tend to show little appreciation for abstract art, even though such works often show a highly skilled organization of visual elements. A key aspect of a positive aesthetic experience concerns the ability of viewers to construct meaning. I propose that viewers attempt to make meaning of artworks due to a sense that art is a communicative process. Here I attempt an application of one intentionalist model of communication, the Gricean framework, to visual …


Improving Investigative Interviews: Facilitating Disclosure Of Information Through Implicit Means, Evan Crawford Dawson Sep 2015

Improving Investigative Interviews: Facilitating Disclosure Of Information Through Implicit Means, Evan Crawford Dawson

Dissertations, Theses, and Capstone Projects

Investigative interviews are essential to intelligence collection. However, eliciting information from subjects is challenging when they are not motivated to cooperate. Psychological research has examined social influence tactics that may influence an interviewee's forthcomingness, however, there has been no focus on implicit methods despite their prominence in the basic social cognitive literature. Research on implicit cognition has found that activating mental concepts can lead people to behave in ways that are semantically related to or metaphorically consistent with the activated concept. In the present research, I sought to examine the concept of disclosure and test the effects of its activation …


A Long-Term Follow-Up Of Crossover Youth: Young Adult Outcomes For Maltreated Youth In The Juvenile Justice System, Carly Lyn Baetz Sep 2015

A Long-Term Follow-Up Of Crossover Youth: Young Adult Outcomes For Maltreated Youth In The Juvenile Justice System, Carly Lyn Baetz

Dissertations, Theses, and Capstone Projects

Crossover youth, those with histories of childhood maltreatment and delinquency, may be at high risk for negative outcomes compared to other youth. However, very little is known about the long-term outcomes for this population. This dissertation compared four groups: youth with histories of child maltreatment and juvenile arrest (n = 180), youth with a history of maltreatment only (n = 428), youth with a history of juvenile arrest only (n = 91), and youth with no history of maltreatment or juvenile arrest (n = 496), on a range of outcomes, including mental health, education, employment, and criminal behavior. Data from …


Maternal Dissociation, Emotional Acceptance And Child Emotion Regulation: A Study Of Residents In A Family Homeless Shelter For Victims Of Domestic Violence, Brian S. Mueller Sep 2015

Maternal Dissociation, Emotional Acceptance And Child Emotion Regulation: A Study Of Residents In A Family Homeless Shelter For Victims Of Domestic Violence, Brian S. Mueller

Dissertations, Theses, and Capstone Projects

The present study examined the relationships between maternal dissociation, mothers' self-described parenting behaviors in child emotion regulation, and the emotion regulatory capacity of their children. These relationships were investigated in a sample of predominately low-income African-American and Latino mothers and children residing in a domestic violence shelter. In this study, I investigated a mediational model relating maternal dissociation, mother's acceptance of child emotions, and child difficulties in emotion regulation and behavior. I predicted that mothers who reported more dissociative experiences would demonstrate less awareness and acceptance of emotions when they responded to children's sadness, fear, happiness, and anger. I also …


The Effect Of Retention Interval On Temporal Control Of Responding In Rats On The Peak Interval Procedure, Catherine Tsiris Sep 2015

The Effect Of Retention Interval On Temporal Control Of Responding In Rats On The Peak Interval Procedure, Catherine Tsiris

Dissertations, Theses, and Capstone Projects

A considerable body of literature on time perception has investigated the effects of short intratrial retention intervals (RI) in the seconds range, on temporal performance, however there is a dearth of research examining the effects of long, intersession RIs (hours to days range) on timing. The present study examined the effect of two different RI durations (2 days and 70 days) on time estimates in subjects on the peak interval procedure. Twenty-four rats, eight per group, were exposed to one of three conditions. The experimental group was trained at 5 months and tested after a 70-day RI. One control group …


Emotion Dysregulation: A Predictor For Cbt Treatment Outcomes In A Comorbid Ptsd And Sud Population, Jennifer Robin Wallach Sep 2015

Emotion Dysregulation: A Predictor For Cbt Treatment Outcomes In A Comorbid Ptsd And Sud Population, Jennifer Robin Wallach

Dissertations, Theses, and Capstone Projects

Trauma has been shown to disrupt self-regulatory processes; emotion regulation deficits have also been implicated in the initiation and maintenance of substance use disorders (SUDs). Treatments for these complex comorbid problems utilize a variety of approaches. However, to date, few studies have examined the effect of various available treatments on emotion dysregulation in this population. This study extends the research on emotion regulation among the population with comorbid posttraumatic stress disorder (PTSD) and SUD. This study is a secondary analysis of part of the data from a randomized clinical trial assessing the relative efficacy of two active treatment conditions for …


Self-Esteem As A Predictor Of Posttraumatic Growth And Adaptation Among Maltreated Early Adolescents, Hadar Schwartz Sep 2015

Self-Esteem As A Predictor Of Posttraumatic Growth And Adaptation Among Maltreated Early Adolescents, Hadar Schwartz

Dissertations, Theses, and Capstone Projects

Child maltreatment, including neglect and physical, sexual, and emotional abuse, affects 12% of American children each year (Wildeman, Emanal, Leventhal, Putnam-Hornstein, Waldfogel, & Lee, 2014). Maltreatment can be devastating to an individual's development and is associated with considerable negative psychological sequelae, including high rates of depression and problem behaviors, impaired peer relationships, and low self-esteem (e.g., Bolger, Patterson, & Kupersmidt, 1998; Cicchetti & Carlson, 1989; Kim & Cicchetti, 2006; Swanston, Tebbutt, O'Toole, & Oates, 1997; Toth, Manly, & Cicchetti, 1992). However, despite a historic emphasis on the negative effects of trauma, not all children experience traumatic reactions (Cicchetti & Rogosch, …


The Insanity Defense, Public Anger, And The Potential Impact On Attributions Of Responsibility And Punishment, Chioma Ajoku Sep 2015

The Insanity Defense, Public Anger, And The Potential Impact On Attributions Of Responsibility And Punishment, Chioma Ajoku

Dissertations, Theses, and Capstone Projects

Research indicates that the general public perceives the insanity defense negatively and inaccurately despite the infrequency with which it is pled and the realities often surrounding those who plead the defense. The negative and inaccurate perception of the insanity defense, combined with the potentially increased punitive judgments the defense elicits, suggests that emotion may play a role in perception of the insanity defense. In particular, the psychological literature on anger may contain answers to reactions toward the insanity defense. The current research explored the role of anger on punitive judgments toward a defendant pleading not guilty by reason of insanity …


The Sensitive Psychopath: Assessing Construct Overlap Between Secondary Psychopathy And Borderline Personality Disorder, Trevor H. Barese Sep 2015

The Sensitive Psychopath: Assessing Construct Overlap Between Secondary Psychopathy And Borderline Personality Disorder, Trevor H. Barese

Dissertations, Theses, and Capstone Projects

The literature suggests substantial overlap between secondary psychopathy and Borderline Personality Disorder (BPD). The current study evaluates the degree of construct overlap between BPD and secondary psychopathy within a sample of offenders mandated to treatment in the community. Diagnostic overlap and associations with clinically relevant correlates were assessed to estimate the degree of convergence between the two disorders and divergence from primary psychopathy. The goal of this study was to evaluate the pragmatic utility of maintaining discrete diagnostic categories for secondary psychopathy and BPD rather than identifying secondary psychopaths as offenders with BPD. The Structured Clinical Interview for DSM-IV Axis …


Whistles Of Sympatric Species Of Bottlenose Dolphins (Tursiops Truncatus) And Spotted Dolphins (Stenella Frontalis) In The Bahamas: Acoustic Characteristics And Contextual Use, Jennifer Daisy Kaplan Sep 2015

Whistles Of Sympatric Species Of Bottlenose Dolphins (Tursiops Truncatus) And Spotted Dolphins (Stenella Frontalis) In The Bahamas: Acoustic Characteristics And Contextual Use, Jennifer Daisy Kaplan

Dissertations, Theses, and Capstone Projects

Bottlenose and spotted dolphins in the Bahamas frequently interact in social, socio-sexual, and aggressive encounters, and whistles are thought to play a key role in their communication. Concurrent vocal and behavioral recordings of wild sympatric species of Atlantic spotted dolphins (Stenella frontalis) and Atlantic bottlenose dolphins (Tursiops truncatus) were collected from three Bahamas populations, and the acoustic parameters, structure, and contextual use of their whistles were analyzed. The mean acoustic parameters of spotted dolphins in the Bimini and White Sand Ridge Bahamas populations were higher in frequency than those of bottlenose dolphins, but bottlenose dolphins produced whistles that had higher …


Deception As Forgery: The Role Of Reference Information In Honesty And Deceit, Timothy John Luke Sep 2015

Deception As Forgery: The Role Of Reference Information In Honesty And Deceit, Timothy John Luke

Dissertations, Theses, and Capstone Projects

Using concepts derived from cybernetics, self-presentation theory, and research on human self-regulation, I develop a cybernetic perspective of deception and self-presentation. In this perspective, human communication, both honest and deceptive, is controlled by feedback mechanisms. I report two studies designed to test the basic prediction derived from the cybernetic framework that deceivers are able to better emulate truth-tellers when they have access to relevant reference information about the way truth-tellers behave. Each study manipulated liars' and truth-tellers' access to reference information in a different manner. In Study 1, some participants viewed video recordings of people being interviewed in a manner …


The Role Of Posterior Parietal Cortex In Episodic Memory Retrieval: Transcranial Direct Current Stimulation Studies (Tdcs), Denise Pergolizzi Sep 2015

The Role Of Posterior Parietal Cortex In Episodic Memory Retrieval: Transcranial Direct Current Stimulation Studies (Tdcs), Denise Pergolizzi

Dissertations, Theses, and Capstone Projects

Neuroimaging studies of recognition memory have shown that greater activity in the lateral posterior parietal cortex (PPC) correlates with successful recognition in a variety of paradigms, but experimental techniques that manipulate brain activity are necessary to determine the specific contribution of the PPC in episodic memory retrieval. Transcranial Direct Current Stimulation (tDCS) is a non-invasive technique that can be used to manipulate cortical excitability. The collection of experiments that comprise this dissertation use tDCS to determine: 1) whether or not the lateral PPC is causally involved in episodic retrieval, and 2) whether the lateral PPC has a direct role in …


The Reciprocal Relationship Among Object Relations, Attention, And Language In A Sample Of School-Aged Children, Katherine Ann Eiges Sep 2015

The Reciprocal Relationship Among Object Relations, Attention, And Language In A Sample Of School-Aged Children, Katherine Ann Eiges

Dissertations, Theses, and Capstone Projects

Background: Object relations (OR) disturbances are implicated in a broad range of socio-emotional problems and psychopathology in childhood, which are also common among children diagnosed with attention and language impairments. Though attachment-based factors are shown to play a role in the socio-emotional adjustment of children with learning disabilities, the specific influences of attention and language deficits on OR development is unknown. The present study aims to investigate the reciprocal influences of attention and language functioning on OR development. An empirically established OR measure for the Rorschach was systematically adapted to the Thematic Apperception Test (TAT) and examined for convergent validity …


Maternal Substance Use Disorder, Difficult Temperament And Child Psychopathology: Examining A Biopsychosocial Model For The Intergenerational Transmission Of Vulnerability, Wendy Carolina Franco Sep 2015

Maternal Substance Use Disorder, Difficult Temperament And Child Psychopathology: Examining A Biopsychosocial Model For The Intergenerational Transmission Of Vulnerability, Wendy Carolina Franco

Dissertations, Theses, and Capstone Projects

Background: Substance abuse is a significant issue that affects the lives of adults and children in our society. Children of substance abusing parents are at greater risk for poor psychosocial adjustment and psychopathology. The present study drew on biopsychosocial and epigenetic approaches to study vulnerability and resilience in children. The aim was to advance the understanding of child psychopathology and of intergenerational effects of maternal substance use disorder (SUD) by examining the independent and combined contributions of risk factors for child psychopathology in children of mothers with SUD. Employing a "goodness of fit model," which posits that adverse child outcomes …


The 'In-Group Advantage' For Perceiving Emotion Across Demographic Groups And Communication Channels, Thomas Myers Sep 2015

The 'In-Group Advantage' For Perceiving Emotion Across Demographic Groups And Communication Channels, Thomas Myers

Dissertations, Theses, and Capstone Projects

The ability to perceive emotions in others is critical to successful social interaction. While much research has been conducted on some of the factors affecting emotion perception, other areas have received relatively little attention and, thus, are not well understood. There is growing evidence to suggest that various demographic factors, as well as their interactions, impact the accuracy of emotion perception. The impact of these factors seems to vary as a function of the particular channel (e.g., facial, prosodic, and lexical) through which emotions are perceived and may even be influenced by the presence of an 'in-group advantage' (IGA; Elfenbein …


Senescent Changes In Orientation, Frequency, And 3-D Slant And Shape Perception, Danny Tam Sep 2015

Senescent Changes In Orientation, Frequency, And 3-D Slant And Shape Perception, Danny Tam

Dissertations, Theses, and Capstone Projects

The ability to perceive the 3-Dimensional world is effortless despite the fact that the input to the visual system is 2-Dimensional. Attempts to derive biologically plausible models of shape from texture have focused on how changes in orientation and spatial frequency information are processed based on the response properties of primary visual cortex (V1) neurons. However, the relative contributions of orientation and spatial frequency information in detecting slant and shape from 3-D surfaces are not well understood. Additionally, in senescence, changes in optical components of the eye result in reduced frequency sensitivity, but whether concurrent neurophysiological changes affect the ability …


Policy Implications Of A Predictive Validity Study Of The Specialized High School Admissions Test At Three Elite New York City High Schools, Jonathan James Taylor Sep 2015

Policy Implications Of A Predictive Validity Study Of The Specialized High School Admissions Test At Three Elite New York City High Schools, Jonathan James Taylor

Dissertations, Theses, and Capstone Projects

Although admission to New York City's elite public high schools has been controversial because of the disproportionate representation by ethnicity and gender of students admitted, there has been no research on the Specialized High School Admissions Test (SHSAT), the sole admissions criterion. This dissertation had four primary questions: (1) What is the predictive validity of the SHSAT? (2) Would the use of NYC achievement test scores improve prediction? (3) Does the SHSAT exhibit equal predictive validity across gender? and (4) Do disadvantaged students admitted to the Discovery Program with test scores below the cutoff earn grades comparable to regularly admitted …


Working Memory Deficits And Emotion Dysregulation In Youth With Attention-Deficit/Hyperactivity Disorder: Understanding Relationships And Treatment Implications, Jodi Zehava Uderman Sep 2015

Working Memory Deficits And Emotion Dysregulation In Youth With Attention-Deficit/Hyperactivity Disorder: Understanding Relationships And Treatment Implications, Jodi Zehava Uderman

Dissertations, Theses, and Capstone Projects

Evidence suggests that working memory (WM) impairment is a primary deficit in attention-deficit/hyperactivity disorder (ADHD), underlying core symptoms of the disorder and associated impairments. However, the relationship between deficits in different WM components and emotional problems specifically in ADHD has not yet been studied. Knowledge of the cognitive substrates contributing to emotional deficits in ADHD could inform efforts toward refining cognitive remediation as a treatment for emotion dysregulation in this population.

The first aim of this study (Aim 1) investigated whether WM deficits, as a global construct, were related to and mediated the relationship between ADHD and emotion dysregulation. The …


Wh-Question Processing In Children With Cochlear Implants, Zarabeth Waldman Deluca Sep 2015

Wh-Question Processing In Children With Cochlear Implants, Zarabeth Waldman Deluca

Dissertations, Theses, and Capstone Projects

Children with cochlear implants (CIs) have exhibited difficulty accurately answering and producing wh-questions. The syntactic construction of wh-questions include syntactic movement, whereby the wh-question phrase that replaces the subject or object noun is fronted to the beginning of the sentence. This leaves a syntactic gap at the subject or object's original location, to be filled by the listener during immediate language processing. One view is that this syntactic gap is resolved by retaining that filler concept in working memory (WM), until it can be reintegrated into the wh-question. However, the CI population is also notable for WM deficits, which may …


Interleukin-1 (Il-1) As A Potential Contributor To The Pathophysiology Of Alzheimer's Disease, Sara Nicole Resch Sep 2015

Interleukin-1 (Il-1) As A Potential Contributor To The Pathophysiology Of Alzheimer's Disease, Sara Nicole Resch

Dissertations, Theses, and Capstone Projects

Elevations of the pro-inflammatory cytokine interleukin-1 (IL-1) have been reported as part of the inflammatory response to injury and neurodegenerative disorders. The observation of increased IL-1 levels in the brains of patients with Alzheimer's disease (AD) triggered over two decades of research implicating IL-1 in the disease pathogenesis. IL-1 has been suggested to modulate a variety of actions related to AD pathology, including the processing of the Aβ precursor protein and deposition of amyloid plaques. IL-1 also activates glial cells and induces recruitment of leukocytes and peripheral macrophages to the CNS across the blood-brain barrier (BBB). When exposed to IL-1, …