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Full-Text Articles in Social and Behavioral Sciences
Feeling The Heat? Substantial Variation In Temperatures Does Not Affect The Proportion Of Males Born In Australia, Barnaby J. Dixson, John Haywood, Philip J. Lester, Diane K. Ormsby
Feeling The Heat? Substantial Variation In Temperatures Does Not Affect The Proportion Of Males Born In Australia, Barnaby J. Dixson, John Haywood, Philip J. Lester, Diane K. Ormsby
Human Biology Open Access Pre-Prints
The global proportion of male births has been shown to vary with climate, with a higher proportion of male births documented in colder climates. Here we examined the hypothesis that ambient temperature predicts fluctuations in the proportion of male births in Australia and within seven Australian states using historical annual data spanning 1910-2009. We predicted that within states with tropical ambient temperatures the proportion of male births would decrease when ambient temperatures are higher. Considering the national composite births for the whole of Australia first, the proportion of males born ranged only from 0.510 to 0.517. We observed no relationship …
Stress-Induced Retrotranslocation Of Clusterin/Apoj Into The Cytosol, P Nizard, Suzanne Tetley, Y Le Drean, T Watrin, P Le Goff, Mark R. Wilson, Denis Michel
Stress-Induced Retrotranslocation Of Clusterin/Apoj Into The Cytosol, P Nizard, Suzanne Tetley, Y Le Drean, T Watrin, P Le Goff, Mark R. Wilson, Denis Michel
Mark R Wilson
Clusterin is a usually secreted glycoprotein with chaperone properties. Recently, it has been suggested that clusterin isoforms reside in the nuclear and cytosolic compartments of human cell types, where they can influence various cellular programs including DNA repair, transcription and apoptosis. Several mechanisms have been proposed to explain this atypical location, including alternative transcription initiation and alternative splicing. However none of these have been unequivocally established as occurring in live cells. Here we provide direct experimental evidence that in live intact cells, under certain stress conditions, clusterin can evade the secretion pathway and reach the cytosol. This was demonstrated using …