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Full-Text Articles in Social and Behavioral Sciences
Notes On Hypothesis Testing Under A Single-Stage Design In Phase Ii Trial, Kung-Jong Lui
Notes On Hypothesis Testing Under A Single-Stage Design In Phase Ii Trial, Kung-Jong Lui
Journal of Modern Applied Statistical Methods
A primary objective of a phase II trial is to determine future development is warranted for a new treatment based on whether it has sufficient activity against a specified type of tumor. Limitations exist in the commonly-used hypothesis setting and the standard test procedure for a phase II trial. This study reformats the hypothesis setting to mirror the clinical decision process in practice. Under the proposed hypothesis setting, the critical points and the minimum required sample size for a desired power of finding a superior treatment at a given α -level are presented. An example is provided to illustrate how …
Generalized Variances Ratio Test For Comparing K Covariance Matrices From Dependent Normal Populations, Marcelo Angelo Cirillo, Daniel Furtado Ferreira, Thelma Sáfadi, Eric Batista Ferreira
Generalized Variances Ratio Test For Comparing K Covariance Matrices From Dependent Normal Populations, Marcelo Angelo Cirillo, Daniel Furtado Ferreira, Thelma Sáfadi, Eric Batista Ferreira
Journal of Modern Applied Statistical Methods
New tests based on the ratio of generalized variances are presented to compare covariance matrices from dependent normal populations. Monte Carlo simulation concluded that the tests considered controlled the Type I error, providing empirical probabilities that were consistent with the nominal level stipulated.