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Full-Text Articles in Social and Behavioral Sciences
Molecular Dynamics Analysis Of Apolipoprotein-D - Lipid Hydroperoxide Interactions: Mechanism For Selective Oxidation Of Met-93, Aaron J. Oakley, Surabhi Bhatia, Heath Ecroyd, Brett Garner
Molecular Dynamics Analysis Of Apolipoprotein-D - Lipid Hydroperoxide Interactions: Mechanism For Selective Oxidation Of Met-93, Aaron J. Oakley, Surabhi Bhatia, Heath Ecroyd, Brett Garner
Heath Ecroyd
Background: Recent studies suggest reduction of radical-propagating fatty acid hydroperoxides to inert hydroxides by interaction with apolipoprotein-D (apoD) Met93 may represent an antioxidant function for apoD. The nature and structural consequences of this selective interaction are unknown. Methodology/Principal Findings: Herein we used molecular dynamics (MD) analysis to address these issues. Longtimescale simulations of apoD suggest lipid molecules are bound flexibly, with the molecules free to explore multiple conformations in a binding site at the entrance to the classical lipocalin ligand-binding pocket. Models of 5s- 12s- and 15s hydroperoxyeicosatetraenoic acids were created and the lipids found to wrap around Met93 thus …
The Analysis Of Pattern Change In Intron Sequences, Jinda Kongcharoen, Yan-Xia Lin, Rachel Caldwell, Yiren Yang, Ren Zhang
The Analysis Of Pattern Change In Intron Sequences, Jinda Kongcharoen, Yan-Xia Lin, Rachel Caldwell, Yiren Yang, Ren Zhang
Associate Professor Yan-Xia Lin
The Generalized Bernoulli Modeling approach is used to analyze the pattern change in intron sequences of a model plant species Arabidopsis thaliana. The influence of the intron length and the number of GC on the intron sequence pattern changes is examined. Two other gene properties, the gene expression level and the protein function encoded are also assessed. Among the random sampled intron sequences,10.71% of them have been identified to have sequence pattern change. Our study shows that the number of GC and the intron length significantly influence the intron pattern change while the gene expression level and the protein function …
Direct Detection Of Additives And Degradation Products From Polymers By Liquid Extraction Surface Analysis Employing Chip-Based Nanospray Mass Spectrometry, Martin Paine, Phillip Barker, Shane A. Maclaughlin, Todd W. Mitchell, Stephen J. Blanksby
Direct Detection Of Additives And Degradation Products From Polymers By Liquid Extraction Surface Analysis Employing Chip-Based Nanospray Mass Spectrometry, Martin Paine, Phillip Barker, Shane A. Maclaughlin, Todd W. Mitchell, Stephen J. Blanksby
Stephen Blanksby
Rationale: Polymer-based surface coatings in outdoor applications experience accelerated degradation due to exposure to solar radiation, oxygen and atmospheric pollutants. These deleterious agents cause undesirable changes to the polymers aesthetic and mechanical properties reducing its lifetime. The use of antioxidants such as hindered amine light stabilisers (HALS) retard these degradative processes, however, mechanisms for HALS action and polymer degradation are poorly understood. Methods: Detection of the hindered amine light stabiliser (HALS) TINUVIN®123 (bis (1-octyloxy-2,2,6,6-tetramethyl-4-piperidyl) sebacate) and the polymer degradation products directly from a polyester-based coil coating was achieved by liquid extraction surface analysis (LESA) coupled to a triple quadrupole QTRAP® …
A Petrological, Mineralogical And Geochemical Analysis Of Listwaenite Alteration At Spring Creek Bingara In The Great Serpentinite Belt, New England, Nsw, E Holcroft, Solomon Buckman, I Neuss
A Petrological, Mineralogical And Geochemical Analysis Of Listwaenite Alteration At Spring Creek Bingara In The Great Serpentinite Belt, New England, Nsw, E Holcroft, Solomon Buckman, I Neuss
Solomon Buckman Dr.
No abstract provided.