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Articles 1 - 17 of 17
Full-Text Articles in Social and Behavioral Sciences
Lime Muds And Their Genesis Off-Northwestern India During The Late Quaternary, V P. Rao, A Anil Kumar, S W A Naqvi, Allan R. Chivas, B Sekar, Pratima M. Kessarkar
Lime Muds And Their Genesis Off-Northwestern India During The Late Quaternary, V P. Rao, A Anil Kumar, S W A Naqvi, Allan R. Chivas, B Sekar, Pratima M. Kessarkar
Faculty of Science - Papers (Archive)
Two sediment types were found in five gravity cores collected from water depths between 56 m and 121 m along the northwestern continental margin of India: lime muds were abundant in the lower section while siliciclastic sediments dominated the upper section. Lime mud-dominated sediments in shelf cores contained 60%–75% carbonate, 0.3%–0.6% Sr and terrigenous minerals, whereas those at the shelf break were found to have >90% carbonate, 0.6%–0.8% Sr and traces of terrigenous minerals. Aragonite needles showing blunt edges, jointed needles and needles wrapped in smooth aragonite cement were found to be common. Stable (O and C) isotopes of lime …
Selective Reduction Of Hydroperoxyeicosatetraenoic Acids To Their Hydroxy Derivatives By Apolipoprotein D: Implications For Lipid Antioxidant Activity And Alzheimer's Disease, Surabhi Bhatia, Bianca Knoch, Jenny Wong, Woojin Scott Kim, Paul Else, Aaron J. Oakley, Brett Garner
Selective Reduction Of Hydroperoxyeicosatetraenoic Acids To Their Hydroxy Derivatives By Apolipoprotein D: Implications For Lipid Antioxidant Activity And Alzheimer's Disease, Surabhi Bhatia, Bianca Knoch, Jenny Wong, Woojin Scott Kim, Paul Else, Aaron J. Oakley, Brett Garner
Faculty of Science - Papers (Archive)
ApoD (apolipoprotein D) is up-regulated in AD (Alzheimer's disease) and upon oxidative stress. ApoD inhibits brain lipid peroxidation in vivo, but the mechanism is unknown. Specific methionine residues may inhibit lipid peroxidation by reducing radical-propagating L-OOHs (lipid hydroperoxides) to non-reactive hydroxides via a reaction that generates MetSO (methionine sulfoxide). Since apoD has three conserved methionine residues (Met49, Met93 and Met157), we generated recombinant proteins with either one or all methionine residues replaced by alanine and assessed their capacity to reduce HpETEs (hydroperoxyeicosatetraenoic acids) to their HETE (hydroxyeicosatetraenoic acid) derivatives. ApoD, apoDM49-A and apoDM157-A all catalysed the reduction of HpETEs to …
Negotiating Change: Working With Children And Their Employers To Transform Child Domestic Work In Iringa, Tanzania, Natascha Klocker
Negotiating Change: Working With Children And Their Employers To Transform Child Domestic Work In Iringa, Tanzania, Natascha Klocker
Faculty of Science - Papers (Archive)
This paper documents the practical and action-oriented findings of an investigation into child domestic work undertaken in Iringa, Tanzania from 2005 to 2007. It provides an overview of the experiences of both child domestic workers and their employers, before discussing their suggestions for how child domestic working arrangements may be improved. The latter sections of the paper relate the attempts to regulate child domestic work that emerged from such dialogue. In providing detailed information on that process, the paper is positioned within the field of action research and resists the boundary frequently applied between academia and activism. It also moves …
Nanoesi Mass Spectrometry Of Rubisco And Rubisco Activase Structures And Their Interactions With Nucleotides And Sugar Phosphates, Michelle Blayney, Spencer M. Whitney, Jennifer L. Beck
Nanoesi Mass Spectrometry Of Rubisco And Rubisco Activase Structures And Their Interactions With Nucleotides And Sugar Phosphates, Michelle Blayney, Spencer M. Whitney, Jennifer L. Beck
Faculty of Science - Papers (Archive)
Ribulose bisphosphate carboxylase/oxygenase (Rubisco) is the protein that is responsible for the fixation of carbon dioxide in photosynthesis. Inhibitory sugar phosphate molecules, which can include its substrate ribulose-1,5- bisphosphate (RuBP), can bind to Rubisco catalytic sites and inhibit catalysis. These are removed by interaction with Rubisco activase (RA) via an ATP hydrolytic reaction. Here we show the first nanoESI mass spectra of the hexadecameric Rubisco and of RA from a higher plant (tobacco). The spectra of recombinant, purified RA revealed polydispersity in its oligomeric forms (up to hexamer) and that ADP was bound. ADP was removed by dialysis against a …
Corrigendum To ‘‘The Chaperone Action Of Bovine Milk As1- And As2-Caseins And Their Associated Form As-Casein’’ [Arch. Biochem. Biophys. 510 (2011) 42–52], Teresa M. Treweek, David C. Thorn, William E. Price, John A. Carver
Corrigendum To ‘‘The Chaperone Action Of Bovine Milk As1- And As2-Caseins And Their Associated Form As-Casein’’ [Arch. Biochem. Biophys. 510 (2011) 42–52], Teresa M. Treweek, David C. Thorn, William E. Price, John A. Carver
Faculty of Science - Papers (Archive)
No abstract provided.
Patterns Of Demography For Rocky-Shore, Intertidal Invertebrates Approaching Their Geographical Range Limits: Tests Of The Abundant-Centre Hypothesis In South-Eastern Australia, Eszter Z. Hidas, David J. Ayre, Todd E. Minchinton
Patterns Of Demography For Rocky-Shore, Intertidal Invertebrates Approaching Their Geographical Range Limits: Tests Of The Abundant-Centre Hypothesis In South-Eastern Australia, Eszter Z. Hidas, David J. Ayre, Todd E. Minchinton
Faculty of Science - Papers (Archive)
The abundant-centre hypothesis predicts that species' abundances peak at the centre of their geographical ranges and decline gradually towards their range limits. We tested predictions of this hypothesis for three rocky-shore, intertidal invertebrates with planktonic larvae (the whelk, Morula marginalba, the snail, Afrolittorina pyramidalis, and the barnacle, Tesseropora rosea) by quantifying their patterns of abundance and size, and inferring pulses of recruitment from size-frequency distributions, at multiple spatial scales spanning a 600-km region in south-eastern Australia and encompassing roughly the southern third of their geographical ranges. At the regional scale, abundances for all species were, as predicted, dramatically lower at …
The Interaction Of Alphab-Crystallin With Mature Alpha-Synuclein Amyloid Fibrils Inhibits Their Elongation, Christopher A. Waudby, Tuomas P. J Knowles, Glyn L. Devlin, Jeremy N. Skepper, Heath Ecroyd, John A. Carver, Mark E. Welland, John Christodoulou, Christopher M. Dobson, Sarah Meehan
The Interaction Of Alphab-Crystallin With Mature Alpha-Synuclein Amyloid Fibrils Inhibits Their Elongation, Christopher A. Waudby, Tuomas P. J Knowles, Glyn L. Devlin, Jeremy N. Skepper, Heath Ecroyd, John A. Carver, Mark E. Welland, John Christodoulou, Christopher M. Dobson, Sarah Meehan
Faculty of Science - Papers (Archive)
alphaB-Crystallin is a small heat-shock protein (sHsp) that is colocalized with alpha-synuclein (alphaSyn) in Lewy bodies—the pathological hallmarks of Parkinson's disease—and is an inhibitor of alphaSyn amyloid fibril formation in an ATP-independent manner in vitro. We have investigated the mechanism underlying the inhibitory action of sHsps, and here we establish, by means of a variety of biophysical techniques including immunogold labeling and nuclear magnetic resonance spectroscopy, that alphaB-crystallin interacts with alphaSyn, binding along the length of mature amyloid fibrils. By measurement of seeded fibril elongation kinetics, both in solution and on a surface using a quartz crystal microbalance, this binding …
Distribution Of Class 1 Integrons With Is26-Mediated Deletions In Their 3'-Conserved Segments In Escherichia Coli Of Human And Animal Origin., Fay E. Dawes, Alexander Kuzevski, Karl A Bettelheim, Michael A Hornitzky, Steven P Djordjevic, Mark J. Walker
Distribution Of Class 1 Integrons With Is26-Mediated Deletions In Their 3'-Conserved Segments In Escherichia Coli Of Human And Animal Origin., Fay E. Dawes, Alexander Kuzevski, Karl A Bettelheim, Michael A Hornitzky, Steven P Djordjevic, Mark J. Walker
Faculty of Science - Papers (Archive)
Class 1 integrons play a role in the emergence of multi-resistant bacteria by facilitating the recruitment of gene cassettes encoding antibiotic resistance genes. 512 E. coli strains sourced from humans (n = 202), animals (n = 304) and the environment (n = 6) were screened for the presence of the intI1 gene. In 31/79 integron positive E. coli strains, the gene cassette regions could not be PCR amplified using standard primers. DNA sequence analysis of 6 serologically diverse strains revealed atypical integrons harboured the dfrA5 cassette gene and only 24 bp of the integron 3'-conserved segment (CS) remained, due to …
Molecular And Morphological Description Of A Hepatozoon Species In Reptiles And Their Ticks In The Northern Territory, Australia, Inger-Marie E. Vilcins, Beata Ujvari, Julie M. Old, Elizabeth Deane
Molecular And Morphological Description Of A Hepatozoon Species In Reptiles And Their Ticks In The Northern Territory, Australia, Inger-Marie E. Vilcins, Beata Ujvari, Julie M. Old, Elizabeth Deane
Faculty of Science - Papers (Archive)
Ticks, representing 3 species of Amblyomma, were collected from the water python (Liasis fuscus) and 3 additional reptile species in the Northern Territory, Australia, and tested for the presence of Hepatozoon sp., the most common blood parasites of snakes. In addition, blood smears were collected from 5 reptiles, including the water python, and examined for the presence of the parasite. Hepatozoon sp. DNA was detected in all tick and reptile species, with 57.7% of tick samples (n = 187) and 35.6% of blood smears (n = 35) showing evidence of infection. Phylogenetic analysis of the 18S rRNA gene demonstrated that …
Sulphur-Tagged Metal-Organic Frameworks And Their Post-Synthetic Oxidation, Andrew D. Burrows, Christopher G. Frost, Mary F. Mahon, Christopher Richardson
Sulphur-Tagged Metal-Organic Frameworks And Their Post-Synthetic Oxidation, Andrew D. Burrows, Christopher G. Frost, Mary F. Mahon, Christopher Richardson
Faculty of Science - Papers (Archive)
No abstract provided.
Nanofiber Mats From Dna, Swnts, And Poly(Ethylene Oxide) And Their Application In Glucose Biosensors, Jun Chen, Chee O. Too, Gordon G. Wallace, Tuan A Nguyen, Violetta Misoska, Yong Liu
Nanofiber Mats From Dna, Swnts, And Poly(Ethylene Oxide) And Their Application In Glucose Biosensors, Jun Chen, Chee O. Too, Gordon G. Wallace, Tuan A Nguyen, Violetta Misoska, Yong Liu
Faculty of Science - Papers (Archive)
Ultrafine fibers with diameters ranging from 50 to 300 nm were prepared from DNA/single-walled carbon nanotubes (SWNTs)/poly(ethylene oxide) blended dispersion. Well-defined electrospun fibers were obtained by good control of key dispersion properties related to electrospinning, such as ionic conductivity, surface tension, and viscosity. Raman spectroscopy confirmed the presence of SWNT in the resulting fibers, indicating good interaction between DNA and SWNT. The resulting fibers also exhibited electroactive behavior and could be used as an immobilization matrix for a glucose oxidase enzyme biosensor. The sensor response was linear up to 20 mM glucose with a sensitivity of 2.4 mA cm -2 …
Synthesis Of Novel 3'-Spirocyclic-Oxindole Derivatives And Assessment Of Their Cytostatic Activities, Sarah Yong, Alison T. Ung, Stephen G. Pyne, Brian W. Skelton, Allan H. White
Synthesis Of Novel 3'-Spirocyclic-Oxindole Derivatives And Assessment Of Their Cytostatic Activities, Sarah Yong, Alison T. Ung, Stephen G. Pyne, Brian W. Skelton, Allan H. White
Faculty of Science - Papers (Archive)
The synthesis of some novel 3′-spirocyclic-oxindole compounds, based on the spiro[indole-3,5′-isoxazolidin]-2(1H)-one, the 2′H-spiro[indole-3,6′-[1,3]oxazinane]-2,2′(1H)-dione and the 2′H-spiro[indoline-3,3′-pyrrolo[1,2-c][1,3′]oxazine]-1′,2(1H)-dione heterocyclic structures, is described. These compounds were prepared from methyl α-(2-nitrophenyl)acrylate via [1,3]-dipolar cycloaddition reactions with two acyclic nitrones and one cyclic nitrone followed by reduction of the cycloadducts and then treatment with triphosgene. Two of these compounds showed significant cytostatic activity on three cancer cell lines with GI50 values of 2.6–4.1 μM on the human breast cancer cell line, MCF-7.
Syntheses Of Spiro[Cyclopropane-1,3'-Oxindole]-2-Carboxylic Acid And Cyclopropa[C]Quinoline-7b-Carboxylic Acid And Their Derivatives, Sarah Yong, Alison T. Ung, Stephen G. Pyne, Brian W. Skelton, Allan H. White
Syntheses Of Spiro[Cyclopropane-1,3'-Oxindole]-2-Carboxylic Acid And Cyclopropa[C]Quinoline-7b-Carboxylic Acid And Their Derivatives, Sarah Yong, Alison T. Ung, Stephen G. Pyne, Brian W. Skelton, Allan H. White
Faculty of Science - Papers (Archive)
The synthesis of spiro[cyclopropane-1,3′-oxindole]-2-carboxylic acid, including novel 3-(2- and 3-pyridyl)-substituted analogues and the novel cyclopropa[c]quinoline-7b-carboxylic acid and their ester and amide derivatives is described. These syntheses involve diastereoselective cyclopropanation reactions of methyl 2-(2-nitrophenyl)acrylate and (3E)-(pyridin-2-ylmethylene)- and (3E)-(pyridin-3-ylmethylene)-1,3-dihydro-2H-indol-2-one with ethyl (dimethyl sulfuranylidene) acetate (EDSA). The synthesis of methyl cyclopropa[c]quinoline-7b-carboxylate involves a regioselective reductive cyclization of a nitro-diester precursor. The relative stereochemistry of key compounds has been determined by single-crystal X-ray structural analysis.
The Synthesis Of 2',2'-Bis-Benzylisoquinolines And Their Cytostatic Activities, Stephen R. Taylor, Alison T. Ung, Stephen G. Pyne
The Synthesis Of 2',2'-Bis-Benzylisoquinolines And Their Cytostatic Activities, Stephen R. Taylor, Alison T. Ung, Stephen G. Pyne
Faculty of Science - Papers (Archive)
The novel laudanosine dimers in which two laudanosine units are linked via a C-2′ biaryl bond have been prepared by a sequence that involves formation of the biaryl bond first and then formation of the isoquinoline rings. Two of these compounds showed higher cytostatic activity on three cancer cell lines than thalicarpine.
~3,850 Ma Tonalites In The Nuuk Region, Greenland: Geochemistry And Their Reworking Within An Eoarchaean Gneiss Complex, Allen P. Nutman, Vickie C. Bennett, Clark R. L Friend, Kenji Horie, Hiroshi Hidaka
~3,850 Ma Tonalites In The Nuuk Region, Greenland: Geochemistry And Their Reworking Within An Eoarchaean Gneiss Complex, Allen P. Nutman, Vickie C. Bennett, Clark R. L Friend, Kenji Horie, Hiroshi Hidaka
Faculty of Science - Papers (Archive)
The Eoarchaean (>3,600 Ma) Itsaq Gneiss Complex of southern West Greenland is dominated by polyphase orthogneisses with a complex Archaean tectonothermal history. Some of the orthogneisses have c. 3,850 Ma zircons, and they vary from rare single phase metatonalites to more common complexly banded migmatites. This is due to heterogeneous strain, in situ anatexis and granitic veining superimposed during younger tectonothermal events. In the single-phase tonalites with c. 3,850 Ma zircon, oscillatory-zoned prismatic zircon is all 3,850 Ma old, but shows patchy ancient loss of radiogenic Pb. SHRIMP spot analyses and laser ablation ICP-MS depth profiling show that thin …
New U-Pb Shrimp Zircon Ages For Pre-Variscan Orthogneisses From Portugal And Their Bearing On The Evolution Of The Ossa-Morena Tectonic Zone, Umberto G. Cordani, Allen Phillip Nutman, Antonio S. Andrade, Jose F. Santos, Maria Do Rosario Azevedo, Maria Helena Mendes, Manuel S. Pinto
New U-Pb Shrimp Zircon Ages For Pre-Variscan Orthogneisses From Portugal And Their Bearing On The Evolution Of The Ossa-Morena Tectonic Zone, Umberto G. Cordani, Allen Phillip Nutman, Antonio S. Andrade, Jose F. Santos, Maria Do Rosario Azevedo, Maria Helena Mendes, Manuel S. Pinto
Faculty of Science - Papers (Archive)
New SHRIMP U-Pb zircon ages for the Portalegre and Alcáçovas orthogneisses document a complex pre-Variscan history for the Iberian basement in Portugal. The available geochemical and geochronological data for the Alcáçovas orthogneiss (ca. 540 Ma) tend to favor its involvement in a Cadomian orogenic event. This is consistent with the development of an active continental margin setting at the end of the Proterozoic and supports a Gondwanan provenance for the Iberian crust. On the other hand, the Ordovician emplacement age obtained for the magmatic precursors of the Portalegre orthogneisses (497 ± 10 Ma) provides additional evidence for the occurrence of …
Macrochannels And Their Significance For Flood-Risk Minimisation, West Dapto, New South Wales, E. L. Roper, Ivars Reinfelds, Gerald C. Nanson
Macrochannels And Their Significance For Flood-Risk Minimisation, West Dapto, New South Wales, E. L. Roper, Ivars Reinfelds, Gerald C. Nanson
Faculty of Science - Papers (Archive)
A prominent characteristic of streams draining catchments in West Dapto, New South Wales, are well developed macrochannels that have formed within alluvial terraces in mid-catchment zones. A detailed hydraulic modelling study using HEC-RAS, HEC-GeoRAS and Arcview GIS indicates that these macrochannels are scaled to accommodate high magnitude floods. They offer a significant degree of natural protection from flood events up to and in excess of 100 years recurrence interval, essentially by operating as 'bankfull' channels during such events. Macrochannel landforms can be clearly distinguished and mapped on fine-scale digital elevation models (DEMs) and other GIS data sources such as rectified …