Open Access. Powered by Scholars. Published by Universities.®
Social and Behavioral Sciences Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 11 of 11
Full-Text Articles in Social and Behavioral Sciences
P2x7 Receptor Activation Mediates Organic Cation Uptake Into Human Myeloid Leukaemic Kg-1 Cells, Safina Gadeock, Aleta Pupovac, Vanessa Sluyter, Mari Spildrejorde, Ronald Sluyter
P2x7 Receptor Activation Mediates Organic Cation Uptake Into Human Myeloid Leukaemic Kg-1 Cells, Safina Gadeock, Aleta Pupovac, Vanessa Sluyter, Mari Spildrejorde, Ronald Sluyter
Faculty of Science - Papers (Archive)
The P2X7 purinergic receptor is an ATP-gated cation channel with an emerging role in neoplasia. In this study we demonstrate that the human KG-1 cell line, a model of acute myelogenous leukaemia, expresses functional P2X7. RT-PCR and immunochemical techniques demonstrated the presence of P2X7 mRNA and protein respectively in KG-l cells, as well as in positive control multiple myeloma RPMI 8226 cells. Flow cytometric measurements demonstrated that ATP induced ethidium(+) uptake into KG-l cells suspended in sucrose medium (EC(50) of ∼3 μM), but not into cells in NaCl medium. In contrast, ATP induced ethidium(+) uptake into RPMI 8226 cells suspended …
Hominin Dispersal Into The Nefud Desert And Middle Palaeolithic Settlement Along The Jubbah Palaeolake, Northern Arabia, M Petraglia, Abdullah M. Alsharekh, P Breeze, Christopher Clarkson, Remy Crassard, Nick A. Drake, Huw Groucutt, R Jennings, Adrian Parker, A Parton, Richard Roberts, C Shipton, Carney Matheson, A Al-Omari, M Veall
Hominin Dispersal Into The Nefud Desert And Middle Palaeolithic Settlement Along The Jubbah Palaeolake, Northern Arabia, M Petraglia, Abdullah M. Alsharekh, P Breeze, Christopher Clarkson, Remy Crassard, Nick A. Drake, Huw Groucutt, R Jennings, Adrian Parker, A Parton, Richard Roberts, C Shipton, Carney Matheson, A Al-Omari, M Veall
Faculty of Science - Papers (Archive)
The Arabian Peninsula is a key region for understanding hominin dispersals and the effect of climate change on prehistoric demography, although little information on these topics is presently available owing to the poor preservation of archaeological sites in this desert environment. Here, we describe the discovery of three stratified and buried archaeological sites in the Nefud Desert, which includes the oldest dated occupation for the region. The stone tool assemblages are identified as a Middle Palaeolithic industry that includes Levallois manufacturing methods and the production of tools on flakes. Hominin occupations correspond with humid periods, particularly Marine Isotope Stages 7 …
Structural Insights Into The Dehydroascorbate Reductase Activity Of Human Omega-Class Glutathione Transferases, Huina Zhou, Joseph Brock, Dan Liu, Philip G. Board, Aaron J. Oakley
Structural Insights Into The Dehydroascorbate Reductase Activity Of Human Omega-Class Glutathione Transferases, Huina Zhou, Joseph Brock, Dan Liu, Philip G. Board, Aaron J. Oakley
Faculty of Science - Papers (Archive)
The reduction of dehydroascorbate (DHA) to ascorbic acid (AA) is a vital cellular function. The omega-class glutathione transferases (GSTs) catalyze several reductive reactions in cellular biochemistry, including DHA reduction. In humans, two isozymes (GSTO1-1 and GSTO2-2) with significant DHA reductase (DHAR) activity are found, sharing 64% sequence identity. While the activity of GSTO2-2 is higher, it is significantly more unstable in vitro. We report the first crystal structures of human GSTO2-2, stabilized through site-directed mutagenesis and determined at 1.9Å resolution in the presence and absence of glutathione (GSH). The structure of a human GSTO1-1 has been determined at 1.7Å resolution …
Accordion Vs. Quantum Tectonics: Insights Into Continental Growth Processes From The Paleozoic Of Eastern Gondwanan, Jonathan C. Aitchison, Solomon Buckman
Accordion Vs. Quantum Tectonics: Insights Into Continental Growth Processes From The Paleozoic Of Eastern Gondwanan, Jonathan C. Aitchison, Solomon Buckman
Faculty of Science - Papers (Archive)
The Early Paleozoic Lachlan Fold Belt of eastern Australia is widely regarded as an ancient convergent plate margin beneath which paleo-Pacific (Panthalassic) oceanic lithosphere was continuously subducted. It is cited as the type example of a retreating accretionary orogeny. However, sandstone compositions, the sedimentological nature and timing of chert accumulation and overall stratigraphic architecture are not necessarily consistent with this model. We suggest an alternative explanation for growth of Gondwanan continental margin. Oceanic lithosphere outboard of the passive Gondwana continental margin was subducted beneath an extensive intra-oceanic island arc that now crops out as an allochthonous element (Macquarie arc) within …
Communication: New Insight Into The Barrier Governing Co2 Formation From Oh + Co, Christopher J. Johnson, Berwyck L. Poad, Ben B. Shen, Robert E. Continetti
Communication: New Insight Into The Barrier Governing Co2 Formation From Oh + Co, Christopher J. Johnson, Berwyck L. Poad, Ben B. Shen, Robert E. Continetti
Faculty of Science - Papers (Archive)
Despite its relative simplicity, the role of tunneling in the reaction OH + CO → H + CO(2) has eluded the quantitative predictive powers of theoretical reaction dynamics. In this study a one-dimensional effective barrier to the formation of H + CO(2) from the HOCO intermediate is directly extracted from dissociative photodetachment experiments on HOCO and DOCO. Comparison of this barrier to a computed minimum-energy barrier shows that tunneling deviates significantly from the calculated minimum-energy pathway, predicting product internal energy distributions that match those found in the experiment and tunneling lifetimes short enough to contribute significantly to the overall reaction. …
The Whole Rock Sm-Nd 'Age' For The 2825 Ma Ikkattoq Gneisses (Greenland) Is 800 Ma Too Young: Insights Into Archaean Ttg Petrogenesis, Clark R L Friend, Allen Phillip Nutman, Halfdan Baadsgaard, M John M Duke
The Whole Rock Sm-Nd 'Age' For The 2825 Ma Ikkattoq Gneisses (Greenland) Is 800 Ma Too Young: Insights Into Archaean Ttg Petrogenesis, Clark R L Friend, Allen Phillip Nutman, Halfdan Baadsgaard, M John M Duke
Faculty of Science - Papers (Archive)
The Ikkattoq gneisses of the Archaean gneiss complex in the Nuuk region, southern West Greenland, are the orthogneiss component within the amphibolite facies Tre Brodre terrane. They have mostly granodioritic compositions, with a small amount of quartz diorite. Sm-Nd isotopic data for a quartz diorite and five granodiorite Ikkattoq gneiss samples from within 5 km of the Ikkattoq (fjord) type locality yielded a regression with a slope equivalent to 2005 +/- 52 Ma (MSWD = 0.72). Regardless of the low MSWD, this cannot be the true age of the Ikkattoq gneisses, because all Ikkattoq gneisses yield U-Pb zircon dates of …
Management Implications Of Recent Research Into The Effect Of Bitou Bush Invasion, Kristine O. French, Emilie-Jane Ens, Carl Gosper, Elizabeth Lindsay, Tanya J. Mason, Ben Owers, Natalie A. Sullivan
Management Implications Of Recent Research Into The Effect Of Bitou Bush Invasion, Kristine O. French, Emilie-Jane Ens, Carl Gosper, Elizabeth Lindsay, Tanya J. Mason, Ben Owers, Natalie A. Sullivan
Faculty of Science - Papers (Archive)
We review recent research into the impact of bitou bush (Chrysanthemoides monilifera spp. rotundata (DC.) Norl.) on coastal ecosystems which suggest this weed is having widespread impacts on ecosystem services, flora and fauna. Increased decomposition rates and altered nutrient cycling accompany changes in plant community structure and composition. Changes in invaded habitats influence invertebrate and bird assemblages. We summarise research that shows that the establishment phase of seedlings is the key phase where bitou bush outcompetes native species through both resource and interference competition mechanisms.
Stress-Induced Retrotranslocation Of Clusterin/Apoj Into The Cytosol, P Nizard, Suzanne Tetley, Y Le Drean, T Watrin, P Le Goff, Mark R. Wilson, Denis Michel
Stress-Induced Retrotranslocation Of Clusterin/Apoj Into The Cytosol, P Nizard, Suzanne Tetley, Y Le Drean, T Watrin, P Le Goff, Mark R. Wilson, Denis Michel
Faculty of Science - Papers (Archive)
Clusterin is a usually secreted glycoprotein with chaperone properties. Recently, it has been suggested that clusterin isoforms reside in the nuclear and cytosolic compartments of human cell types, where they can influence various cellular programs including DNA repair, transcription and apoptosis. Several mechanisms have been proposed to explain this atypical location, including alternative transcription initiation and alternative splicing. However none of these have been unequivocally established as occurring in live cells. Here we provide direct experimental evidence that in live intact cells, under certain stress conditions, clusterin can evade the secretion pathway and reach the cytosol. This was demonstrated using …
Get Into The Groove: The Role Of Sound In Generating A Sense Of Belonging In Street Parades, Michelle Duffy, Gordon R. Waitt, Christopher R. Gibson
Get Into The Groove: The Role Of Sound In Generating A Sense Of Belonging In Street Parades, Michelle Duffy, Gordon R. Waitt, Christopher R. Gibson
Faculty of Science - Papers (Archive)
Research undertaken in a range of fields has sought to understand the significance of sound and the processes of listening in making sense of social worlds. This inherently interdisciplinary pursuit has particularly emerged in sociology cultural geography, cultural studies, musicology and music therapy. Yet, a great deal is still not known about the interplays between music, sounds, spaces, bodies and our sense of self
New Pieces To The Archaean Terrane Jigsaw Puzzle In The Nuuk Region, Southern West Greeland: Steps In Transforming A Simple Insight Into A Complex Regional Tectonothermal Model, Clark R L Friend, Allen Phillip Nutman
New Pieces To The Archaean Terrane Jigsaw Puzzle In The Nuuk Region, Southern West Greeland: Steps In Transforming A Simple Insight Into A Complex Regional Tectonothermal Model, Clark R L Friend, Allen Phillip Nutman
Faculty of Science - Papers (Archive)
In the south of the Nuuk region of West Greenland our 1980s mapping recognized four Archaean gneiss terranes (Færingehavn, Tre Brødre, Tasiusarsuaq and Akia terranes) with different protolith ages and separate early tectonothermal histories. Later in the Archaean these were juxtaposed and then experienced the same 2700-2500 Ma tectonothermal events. Here we abandon extrapolation of only these four terranes across the whole region, and distinguish two new terranes in the NE. The northernmost Isukasia terrane (previously regarded as the northernmost exposure of the Færingehavn terrane) consists of Palaeoarchaean rocks (>3600 Ma) tectonically bounded on its south by the 3075-2960 …
Enhanced Tumor Growth In Uv-Irradiated Skin Is Associated With An Influx Of Inflammatory Cells Into The Epidermis, Ronald Sluyter, Gary M. Halliday
Enhanced Tumor Growth In Uv-Irradiated Skin Is Associated With An Influx Of Inflammatory Cells Into The Epidermis, Ronald Sluyter, Gary M. Halliday
Faculty of Science - Papers (Archive)
UV radiation causes a number of cellular changes within the skin which play a role in tumor outgrowth, including immunosuppression and production of growth-enhancing cytokines, Both of these enable tumors to grow but their relative importance in carcinogenesis is poorly defined. In this study, C3H/HeN mice were exposed to a single inflammatory dose of 410 mJ/cm(2) UVB radiation (plus 100 mJ/cm2 UVA radiation) followed by the inoculation of a regressor squamous cell carcinoma into or the painting of oxazolone onto the treated skin. Tumors transplanted 2 or 3 but not 4 days after irradiation had a significantly higher growth rate …