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Full-Text Articles in Social and Behavioral Sciences
Solid-State And Solution-Phase Conformations Of Pseudoproline-Containing Dipeptides, James R. Cochrane, Nima Sayyadi, Danielle Skropeta, Peter Turner, Jack K. Clegg, Katrina A. Jolliffe
Solid-State And Solution-Phase Conformations Of Pseudoproline-Containing Dipeptides, James R. Cochrane, Nima Sayyadi, Danielle Skropeta, Peter Turner, Jack K. Clegg, Katrina A. Jolliffe
Faculty of Science - Papers (Archive)
The conformations of 14 threonine-derived pseudoproline-containing dipeptides (including four d-allo-Thr derivatives) have been investigated by NMR. In solution, the major conformer observed for all dipeptides is that in which the amide bond between the pseudoproline and the preceding amino acid is cis. For dipeptides in which the N-terminus is protected, the ratio of cis- to trans-conformers does not depend significantly on the side chain of the N-terminal amino acid, or the stereochemistry of the Thr residue. However, for dipeptides bearing a free N-terminus, there are significant differences in the ratios of cis- to trans-conformers depending on the side chain present. …
Fragmentation Pathways Of 2,3-Dimethyl-2,3-Dinitrobutane Cations In The Gas Phase, Martin Paine, Benjamin Kirk, Simon Ellis-Steinborner, Stephen J. Blanksby
Fragmentation Pathways Of 2,3-Dimethyl-2,3-Dinitrobutane Cations In The Gas Phase, Martin Paine, Benjamin Kirk, Simon Ellis-Steinborner, Stephen J. Blanksby
Faculty of Science - Papers (Archive)
2,3-Dimethyl-2,3-dinitrobutane (DMNB) is an explosive taggant added to plastic explosives during manufacture making them more susceptible to vapour-phase detection systems. In this study, the formation and detection of gas-phase [M+H](+), [M+Li](+), [M+NH4](+) and [M+Na](+) adducts of DMNB was achieved using electrospray ionisation on a triple quadrupole mass spectrometer. The [M+H](+) ion abundance was found to have a strong dependence on ion source temperature, decreasing markedly at source temperatures above 50 degrees C. In contrast, the [M+Na](+) ion demonstrated increasing ion abundance at source temperatures up to 105 degrees C. The relative susceptibility of DMNB adduct ions toward dissociation was investigated …
A Multi-Centre Randomized, Open-Label Phase Ii Trial Of Erlotinib Plus Gemcitabine Or Gemcitabine Monotherapy As First-Line Therapy In Ecog Ps2 Patients With Chemo-Naive Advanced Nsclc, M. G. Michael, Michael Johnston, Stephen Clarke, Richard De Boer, Phillip R. Clingan, Nick Pavlakis
A Multi-Centre Randomized, Open-Label Phase Ii Trial Of Erlotinib Plus Gemcitabine Or Gemcitabine Monotherapy As First-Line Therapy In Ecog Ps2 Patients With Chemo-Naive Advanced Nsclc, M. G. Michael, Michael Johnston, Stephen Clarke, Richard De Boer, Phillip R. Clingan, Nick Pavlakis
Faculty of Science - Papers (Archive)
No abstract provided.
The Major Toxin From The Australian Common Brown Snake Is A Hexamer With Unusual Gas-Phase Dissociation Properties, Andrew Aquilina
The Major Toxin From The Australian Common Brown Snake Is A Hexamer With Unusual Gas-Phase Dissociation Properties, Andrew Aquilina
Faculty of Science - Papers (Archive)
Asymmetric dissociation of multiply charged proteins assemblies has been frequently reported. This phenomenon, which relies on the dissociation of one or more highly charged monomers, has been shown to provide insights into the structure and organization of large monodisperse and polydisperse assemblies. Here, the process of asymmetric dissociation is investigated using the multi-subunit protein, textilotoxin, which has unusually high structural constraints on its monomers due to multiple disulfide linkages. Initially, it is shown that, contrary to previous reports, textilotoxin is made up of 6, rather than 5 subunits. Furthermore, the hexamer exists as two isoforms, one of which is substantially …