Social and Behavioral Sciences Commons^™

The Probability Distribution Of Distance Tss-Tls Is Organism Characteristic And Can Be Used For Promoter Prediction, Yun Dai, Ren Zhang, Yan-Xia Lin

Associate Professor Yan-Xia Lin

Transcription is a complicated process which involves the interactions of promoter cis-elements with multiple trans-protein factors. The specific interactions rely not only on the specific sequence recognition between the cis- and trans-factors but also on certain spatial arrangement of the factors in a complex. The relative positioning of involved cis-elements provides the framework for such a spatial arrangement. The distance distribution between gene transcription and translation start sites (TSS-TLS) is the subject of the present study to test an assumption that over evolution, the TSS-TLS distance becomes a distinct character for a given organism. Four representative organisms (Escherichia cloi, Saccharomyces …