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Social and Behavioral Sciences Commons™

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Physical Sciences and Mathematics

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2009

Articles 1 - 5 of 5

Full-Text Articles in Social and Behavioral Sciences

Book Review: The Great Warming: Climate Change And The Rise And Fall Of Civilizations, James Fleming Feb 2009

Book Review: The Great Warming: Climate Change And The Rise And Fall Of Civilizations, James Fleming

James R. Fleming

No abstract provided.

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Ethically Notable Videogames: Moral Dilemmas And Gameplay, Jose Zagal Dec 2008

Ethically Notable Videogames: Moral Dilemmas And Gameplay, Jose Zagal

Jose P Zagal

In what ways can we use games to make moral demands of players and encouraging them to reflect on ethical issues? In this article we propose an ethically notable game as one that provides opportunities for encouraging ethical reasoning and reflection. Our analysis of the videogames Ultima IV, Manhunt, and Fire Emblem: Radiant Dawn highlights the central role that moral dilemmas can play towards creating ethically notable games. We discuss the different ways that these are implemented, such as placing players in situations in which their understanding of an ethical system is challenged, or by creating moral tension between the …

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Polymorphic Ros Scavenging Revealed By Cccp In A Lizard, Mats Olsson, Mark Wilson, Caroline Isaksson, Tobias Uller Dec 2008

Polymorphic Ros Scavenging Revealed By Cccp In A Lizard, Mats Olsson, Mark Wilson, Caroline Isaksson, Tobias Uller

Mark R Wilson

Ingestion of antioxidants has been argued to scavenge circulating reactive molecules (e.g., free radicals), play a part in mate choice (by mediating access to this important resource), and perhaps increase life span. However, recent work has come to question these relationships. We have shown elsewhere in the polychromatic lizard, Ctenophorus pictus, that diet supplementation of carotenoids as antioxidants does not depress circulating natural reactive oxygen species (ROS) levels and leads to no corresponding improvement of color traits. However, a much stronger test would be to experimentally manipulate the ROS levels themselves and assess carotenoid-induced ROS depression. Here, we achieve this …

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Variation In Levels Of Reactive Oxygen Species Is Explained By Maternal Identity, Sex And Body-Size-Corrected Clutch Size In A Lizard, Mark Wilson, Mats Olsson, Tobias Uller, Caroline Isaksson, Beth Mott Dec 2008

Variation In Levels Of Reactive Oxygen Species Is Explained By Maternal Identity, Sex And Body-Size-Corrected Clutch Size In A Lizard, Mark Wilson, Mats Olsson, Tobias Uller, Caroline Isaksson, Beth Mott

Mark R Wilson

No abstract provided.

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The Chaperone Action Of Clusterin And Its Putative Role In Quality Control Of Extracellular Protein Folding, Amy Wyatt, Justin Yerbury, Stephen Poon, Rebecca Dabbs, Mark Wilson Dec 2008

The Chaperone Action Of Clusterin And Its Putative Role In Quality Control Of Extracellular Protein Folding, Amy Wyatt, Justin Yerbury, Stephen Poon, Rebecca Dabbs, Mark Wilson

Mark R Wilson

The function(s) of clusterin may depend upon its topological location. A variety of intracellular "isoforms" of clusterin have been reported but further work is required to better define their identity. The secreted form of clusterin has a potent ability to inhibit both amorphous and amyloid protein aggregation. In the case of amorphous protein aggregation, clusterin forms stable, soluble high-molecular-weight complexes with misfolded client proteins. Clusterin expression is increased during many types of physiological and pathological stresses and is thought to function as an extracellular chaperone (EC). The pathology of a variety of serious human diseases is thought to arise as …

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